Municipal Key Laboratory of Clinical Epidemiology

Beijing, China

Municipal Key Laboratory of Clinical Epidemiology

Beijing, China
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Dong J.,Capital Medical University | Liang Y.-Z.,Capital Medical University | Zhang J.,Capital Medical University | Zhang J.,Municipal Key Laboratory of Clinical Epidemiology | And 7 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2017

Aim: To explore the relationship between lipometabolism-related microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) and the presence of coronary artery disease (CAD). Methods: In the present study, 161 stable CAD patients and 149 health controls were enrolled. The expression levels of seven miRNAs (miR-21, miR-24, miR-29a, miR-33a, miR-34a, miR-103a, and miR-122) in PBMCs were qualified by quantitative real-time polymerase chain reaction (qRT-PCR). The miRNA markers that showed significant difference between the two groups were used for further analysis. The risk of miRNA contributing to the presence of CAD was estimated by univariate and multivariate logistic regression models. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results: The expression levels of miR-24, miR-33a, miR-103a, and miR-122 in PBMCs were significantly increased in CAD patients compared with controls and were significantly correlated with blood lipids in both CAD patients and controls. The increased levels of miR-24 (adjusted OR= 1.32, 95% CI 1.07– 1.62, P =0.009), miR-33a (adjusted OR=1.57, 95% CI 1.35– 1.81, P<0.001), miR- 103a (adjusted OR=1.01, 95% CI 1.01–1.02, P<0.001), and miR-122 (adjusted OR=1.03, 95% CI 1.01–1.04, P<0.001) were associated with risk of CAD. We identified a miRNA panel (miR-24, miR-33, miR-103a, and miR-122) that provided a high diagnostic accuracy of CAD (AUC=0.911, 95% CI 0.880 –0.942). Conclusion: The increased expression levels of miR-24, miR-33a, miR-103a, and miR-122 in PBMCs are associated with risk of CAD. A panel of the four miRNAs has considerable clinical value in diagnosing stable CAD. © 2017 Japan Atherosclerosis Society.

Zhang X.,Centers for Disease Control and Prevention | Yu Y.,Capital Medical University | Zhang J.,Capital Medical University | Zhang J.,Municipal Key Laboratory of Clinical Epidemiology | And 10 more authors.
Vaccine | Year: 2014

In recent years, the number of breakthrough cases of varicella (onset >42 days after vaccination) increased each year, and varicella outbreaks continue to occur in Beijing. Data from the Immunization Information System and the Infectious Disease Reporting System demonstrated that in Beijing's Fengtai District, the varicella breakthrough rate increased from 0.7% in 2008 to 2.5% in 2012 and showed an increased trend (P<. 0.001). Among the varicella cases in children (age of 3-15 years), the number of breakthrough cases increased from 167 in 2008 to 622 in 2012, which was 45.2% (n= 1735) of the total child cases (n= 3842). From 2008 to 2012, a total of 62 outbreaks occurred; among the 787 affected child outbreak cases, 61% were vaccinated. Altogether, the results from this study indicated that 1-dose vaccination cannot sufficiently prevent the occurrence of breakthrough cases of varicella or control varicella outbreaks in Beijing's Fengtai District. © 2014 Elsevier Ltd.

Lu J.,Capital Medical University | Lu J.,Municipal Key Laboratory of Clinical Epidemiology | Huang Y.,Beijing Haidian Hospital | Wang Y.,Capital Medical University | And 21 more authors.
PLoS ONE | Year: 2012

Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers. © 2012 Lu et al.

Yan Y.-X.,Capital Medical University | Yan Y.-X.,Municipal Key Laboratory of Clinical Epidemiology | Dong J.,Capital Medical University | Wu L.-J.,Capital Medical University | And 12 more authors.
Journal of Epidemiology | Year: 2013

Background: Glucocorticoid is an important regulator of energy homeostasis. Glucocorticoid receptor (GR) gene polymorphisms that contribute to variability in glucocorticoid sensitivity have been identified. We explored the associations of single-nucleotide polymorphisms (SNPs) of the GR gene with traditional cardiovascular risk factors in the Chinese Han population. Methods: We recruited 762 consecutive adults who underwent a regular physical examination at Beijing Xuanwu Hospital. Blood pressure, glucose, lipid levels (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides), body mass index (BMI), and waist-to-hip ratio were measured. Fourteen tag SNPs and 5 functional SNPs were selected and genotyped using the high-throughput Sequenom genotyping platform. Differences between genotypes/alleles for each SNP were adjusted for sex and age and tested using a general linear model procedure. Various models of inheritance, including additive, dominant, and recessive, were tested. Results: Among the 19 SNPs examined, 5 markers were associated with cardiovascular risk factors. The rs41423247 GG genotype and the rs7701443 AA genotype were associated with higher BMI and systolic blood pressure (P < 0.0004), and the rs17209251 GG genotype was associated with higher systolic blood pressure (P < 0.0004). Lower systolic blood pressure, total cholesterol, and LDL cholesterol were observed among rs10052957 A allele carriers (P < 0.0004), and lower plasma glucose and LDL-cholesterol concentrations were observed among rs2963156 TT carriers (P < 0.0004). Conclusions: Polymorphism of the GR gene was associated with cardiovascular risk factors and may contribute to susceptibility to cardiovascular disease. © 2013 Yu-Xiang Yan et al.

Yan Y.-X.,Capital Medical University | Yan Y.-X.,Municipal Key Laboratory of Clinical Epidemiology | Xiao H.-B.,Capital Medical University | Wang S.-S.,Capital Medical University | And 7 more authors.
Journal of Epidemiology | Year: 2016

Background: Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the stress system, selected parameters of energy homeostasis, and insulin resistance in a Chinese population. Methods: We recruited 766 workers employed at four companies in Beijing. The degree of insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). The highest quartile of HOMA-IR among all study subjects was further defined as insulin resistance in our study. The short standard version of the Copenhagen Psychosocial Questionnaire (COPSOQ) was used to assess job-related psychosocial stress. Pearson's correlation coefficients were calculated between cortisol level and HOMA-IR and components of metabolic syndrome, with stratification by gender. The relationship between cortisol and HOMA-IR independent of obesity was analyzed using a linear mixed model with company as a cluster unit. Results: The values of the two scales of COPSOQ, including "demands at work" and "insecurity at work", were significantly associated with insulin resistance and cortisol concentration (P < 0.05). Cortisol was significantly positively correlated with glucose, HOMA-IR, and waist circumference in males and females (P < 0.05). After adjusting for potential confounders, cortisol was an independent positive predictor for HOMA-IR (P < 0.05). Conclusions: These findings showed that chronic stress was associated with insulin resistance and may contribute to the development of insulin resistance. © 2016 Yu-Xiang Yan et al.

Zhang X.,Capital Medical University | Zhang X.,Fengtai Center for Control and Prevention | Yan Y.,Capital Medical University | Yan Y.,Municipal Key Laboratory of Clinical Epidemiology | And 15 more authors.
Vaccine | Year: 2012

Using data from the Immunization Information System (IIS) and the Infectious Disease Reporting System (IDRS), we have described the epidemiology and analyzed the risk factors for breakthrough varicella in the Fengtai district of Beijing, China. From 2008 to 2011 the breakthrough varicella infection rate (BVR) was 0.65%, 0.85%, 1.08% and 1.56% respectively, thus demonstrating a distinct increasing tendency (P<. 0.001). We also compared the incidence of varicella-related illnesses between the breakthrough varicella cases and unvaccinated cases, and found that the severity of illness in the breakthrough cases was milder than that of unvaccinated cases. Moderate-to-severe cases (P= 0.008, OR = 0.676, 95% CI = 0.505-0.904) were differently distributed in the breakthrough varicella cases and unvaccinated cases. In this study, we demonstrated that floating status (P= 0.031, OR = 1.96, 95% CI = 1.06-3.62), contact history (P<. 0.001, OR = 2.67, 95% CI = 1.59-4.69), time since vaccination (P= 0.006, OR = 1.59, 95% CI = 1.14-2.21), age at vaccination (P= 0.010, OR = 0.59, 95% CI = 0.39-0.88) and combined vaccination (P= 0.026, OR = 3.99, 95% CI = 1.18-13.54) were associated with the occurrence of breakthrough varicella, and among these, floating status is a novel risk factor. This study should provide useful information for the evaluation of the performance of varicella vaccination and prevention in PR China. © 2012 Elsevier Ltd.

Lu J.-P.,Capital Medical University | Lu J.-P.,Municipal Key Laboratory of Clinical Epidemiology | Knezevic A.,Genos Ltd | Wang Y.-X.,Capital Medical University | And 22 more authors.
Journal of Proteome Research | Year: 2011

N-glycans play an essential role in biological process and are associated with age, gender, and body mass parameters in Caucasian populations, whereas no study has been reported in Chinese populations. To investigate the correlation between N-glycan structures and metabolic syndrome (MetS) components, we conducted a population-based study in 212 Chinese Han individuals. The replication study was performed on 520 unrelated individuals from a Croatian island Korcula. The most prominent observation was the consistent positive correlations between different forms of triantennary glycans and negative correlations between glycans containing core-fucose with MetS components including BMI, SBP, DBP, and fasting plasma glucose (FPG) simultaneously. Significant differences in a number of N-glycan traits were also detected between normal and abnormal groups of BMI, BP, and FPG, respectively. In the multivariate analysis, the level of monosialylated glycans (structure loadings = -0.776) was the most correlated with the MetS related risk factors, especially with SBP (structure loadings = 0.907). Results presented here are showing that variations in the composition of the N-glycome in human plasma could represent the alternations of human metabolism and could be potential biomarkers of MetS. © 2011 American Chemical Society.

Wang Y.,Capital Medical University | Wang Y.,Municipal Key Laboratory of Clinical Epidemiology | Wang W.,Capital Medical University | Wang W.,Municipal Key Laboratory of Clinical Epidemiology | And 2 more authors.
Asia-Pacific Journal of Public Health | Year: 2015

Increasing incidence of thyroid cancer has been observed in some countries such as the United States, United Kingdom, France, and so on. Joinpoint regression was used to analyze the incidence of thyroid cancer in Shanghai, China, from 1983 to 2007. The results showed that there were 2 distinct slopes: in men, representing a significant annual percentage change (APC) of 2.6% from 1983 to 2000 (P <.001) followed by a sharp APC of 14.4% (P <.001), and in women, representing a significant APC of 4.9% from 1983 to 2003 (P <.001) followed by a sharp APC of 19.9% (P =.001). The sharp increase in thyroid cancer occurred 5 and 8 years after the iodine supplementation by salt, for men and women, respectively, suggesting that either the developed screening techniques or iodine supplementation might have contributed to the rapid increase in the incidence of thyroid cancer. The burden of thyroid cancer cases is expected to be substantial, based on predictions through 2020. © 2012 APJPH.

Zhao F.,Capital Medical University | Zhao F.,Municipal Key Laboratory of Clinical Epidemiology | Chen Y.,Chinese Academy of Inspection and Quarantine | Ge S.,Capital Medical University | And 15 more authors.
OMICS A Journal of Integrative Biology | Year: 2014

Science journalism is a previously neglected but rapidly growing area of scholarship in postgenomics medicine and socio-technical studies of knowledge-based innovations. Science journalism can help evaluate the quantity and quality of information flux between traditional scientific expert communities and the broader public, for example, in personalized medicine education. Newspapers can play a crucial role in science and health communication, and more importantly, in framing public engagement. However, research on the role of newspaper coverage of genomics-related articles has not been readily available in resource-limited settings. As genomics is rapidly expanding worldwide, this gap in newspaper reportage in China is therefore an important issue. In order to bridge this gap, we investigated the coverage of genomics medicine in eight major Chinese national newspapers, using the China Core Newspapers Full-text Database (CCND) and articles in scientific journals in PubMed from 2000 to 2011. Coverage of genomics medicine in these eight official government Chinese newspapers has remained low, with only 12 articles published per newspaper per year between 2000 and 2011. Between 2000 and 2011, over a 40-fold difference was observed in the number of genomics medicine-related articles in PubMed, as compared to that in newspapers. The numbers of genomics-related articles among the eight major newspapers from 2000 to 2011 were significantly different (p=0.001). Commentary/mini reviews and articles about gene therapy for specific diseases were most frequently published in 2006 and 2011. In parallel, we observed that "cancer gene therapy," "new susceptibility gene locus," and "gene technology revolution" were the top three thematic strands addressed in the newspapers, even though their volume remained low. This study reports on the under-representation of newspaper coverage of genomics medicine in China, despite the vast growth of scientific articles in journals in this knowledge domain. This underscores the need to enhance collaboration between scientists, medical professionals, and journalists as an important strand of overall communications efforts in disseminating genomic medicine knowledge to larger audiences. Yet a substantive question remains to be examined: would traditional journalism, alone, be adequate to address the advances and challenges in genomics medicine in the media? Conversely, should we invest in science journalism programs as a subspecialty in biomedicine so scientists and clinicians acquire the twin scholarship of science/clinical medicine and journalism in their formative education? © Mary Ann Liebert, Inc.

Yan Y.-X.,Capital Medical University | Yan Y.-X.,Municipal Key Laboratory of Clinical Epidemiology | Dong J.,Capital Medical University | Zhang J.,Capital Medical University | And 8 more authors.
Endocrine | Year: 2014

Polymorphisms of the NR3C1 (glucocorticoid receptor) gene have been reported to be associated with altered glucocorticoids sensitivity and changes in body composition and metabolic parameters. This study explored the relationship between single nucleotide polymorphisms (SNPs) of the NR3C1 gene and metabolic syndrome (MetS) in a Chinese population. Fourteen tag-SNPs and five functionally important SNPs in the NR3C1 gene were genotyped in MetS patients (n = 431) and normal controls (n = 461) using the high-throughput Sequenom genotyping platform. Genotype, allelic and haplotype associations were examined using logistic regression and Haploview. There are four SNPs significantly associated with MetS. The T allele of rs2963156 was associated with an increased risk effect for MetS (adjusted OR = 1.66, 95 % CI 1.25–2.22, P = 0.001). By contrast, rs10052957 A allele carriers were significantly associated with a decreased risk of MetS (adjusted OR = 0.58, 95 % CI 0.42–0.80, P = 0.001). Rs41423247 GG genotype (adjusted OR = 2.01, 95 % CI 1.25–3.22, P = 0.004), and rs7701443 AA genotype (adjusted OR = 1.88, 95 % CI 1.24–2.83, P = 0.003) were significantly associated with an increased risk of MetS. Haplotype CGGA is risk conferring (adjusted OR = 1.53, 95 % CI 1.06–2.20, P = 0.023), whereas haplotype CCAG was protective (adjusted OR = 0.30, 95 % CI 0.20–0.47, P < 0.001). Polymorphism of NR3C1 gene is associated with MetS and may contribute to the susceptibility of MetS. © 2014, Springer Science+Business Media New York.

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