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Rauch, Argentina

Salazar M.R.,Clinica Medica | Salazar M.R.,National University of La Plata | Espeche W.G.,Clinica Medica | Espeche W.G.,National University of La Plata | And 18 more authors.
Journal of Human Hypertension | Year: 2015

We evaluated the consequences of excluding the first of three blood pressure (BP) readings in different settings: a random population sample (POS, n=1525), a general practice office (GPO, n=942) and a specialized hypertension center (SHC, n=462). Differences between systolic and diastolic BP (SBP and DBP) estimates obtained including and excluding the first reading were compared and their correlation with ambulatory BP monitoring (ABPM) was estimated. The samples were divided into quartiles according to the difference between the third and the first SBP (3-1ΔSBP). SBP decreased through sequential readings, 3-1ΔSBP was-5.5±9.7 mm Hg (P<0.001),-5.1±10.4 mm Hg (P<0.001) and-6.1±9.3 mm Hg (P<0.001) for POS, GPO and SHC, respectively. However, individuals included in the top quartile of 3-1ΔSBP showed their highest values on the third reading. The mean SBP estimate was significantly higher excluding the first reading (P<0.001), but the differences among both approaches were small (1.5-1.6 mm Hg). Moreover, the correlation between SBP values including and excluding the first reading and daytime ABPM were comparable (r=0.69 and 0.68, respectively). Similar results were observed for DBP. In conclusion, our study does not support the notion of discarding the first BP measurement and suggests that it should be measured repeatedly, regardless the first value. © 2015 Macmillan Publishers Limited All rights reserved. Source

Trujillo-Santos J.,Hospital Universitario Santa Maria Of Rosell | Casa J.M.,Hospital Infanta Cristina | Casado I.,Hospital Universitario Virgen Of Las Nieves | Samperiz A.L.,Hospital Reina Sofia | And 3 more authors.
Thrombosis Research | Year: 2011

The influence of the site of cancer on outcome in cancer women with venous thromboembolism (VTE) is poorly understood. Reliable information on its influence might facilitate better use of prevention strategies. We assessed the 30-day outcome in all women with active cancer in the RIETE Registry, trying to identify if differences exist according to the tumor site. Up to May 2010, 2474 women with cancer and acute VTE had been enrolled. The most common sites were the breast (26%), colon (13%), uterus (9.3%), and haematologic (8.6%) cancers. During the 30-day study period, 329 (13%) patients died. Of them, 71 (2.9%) died of pulmonary embolism (PE), 22 (0.9%) died of bleeding. Fatal PE was more common in women with breast, colorectal, lung or pancreatic cancer (59% of the fatal PEs). Fatal bleeding was more frequent in women with colorectal, haematologic, ovarian cancer or carcinoma of unknown origin (55% of fatal bleedings). © 2011 Elsevier Ltd. Source

Salazar M.R.,Hospital Universitario San Martin | Espeche W.G.,Hospital Universitario San Martin | Aizpurua M.,Hospital Municipal | Sisnieguez B.C.L.,Hospital Universitario San Martin | And 3 more authors.
American Journal of Hypertension | Year: 2014

Background The significance in terms of the cardiovascular outcome of different patterns of blood pressure (BP) response to community-based activities has not been previously studied. The aim of our study was to evaluate the relationship between changes of BP observed during a community- based program and long-term rate of cardiovascular disease (CVD) events. methods A program focused on the prevention of CVDs was implemented in a small city in Argentina over a 6-year period (1997-2003). The program was evaluated using a cohort of 1,526 randomly selected individuals. The population's mean systolic BP (SBP) decreased approximately 5 mm Hg, but BP changes were heterogeneous. Eight years after the intervention had stopped, 1,124 individuals of the cohort were surveyed to evaluate incident CVD events. The sample was divided into 3 SBP change categories during the intervention: decrease (< -5 mm Hg), no change (-5 to 5 mm Hg) and increase (> 5 mm Hg). Cox models were used to estimate the hazard ratio (HR) of CVD events for each category adjusted for age, sex, and baseline BP. results At the end of the intervention, individuals who had increased their SBP showed an adjusted HR for CVD that was double those whose SBP levels decreased or did not change. An inverse relationship between baseline SBP and ΔSBP was observed: individuals with an increase in BP during the intervention had lower SBP at the beginning of the study. conclusions BP increase during the community-based program was an independent predictor of CVD events. © American Journal of Hypertension, Ltd 2014. Source

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