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Fujimoto N.,University of Occupational and Environmental Health Japan | Kubo T.,University of Occupational and Environmental Health Japan | Inatomi H.,Munakata Suikoukai General Hospital | Bui H.T.T.,University of Occupational and Environmental Health Japan | And 3 more authors.
Prostate Cancer and Prostatic Diseases | Year: 2013

Background:Organic anion-transporting polypeptides (OATPs) encoded by SLCO mediate the cellular uptake of many compounds, including androgens. SLCO1B3 and SLCO2B1 are polymorphic, and single-nucleotide polymorphisms of those genes alter androgen transport efficiency. We aimed to investigate the association between genetic variations in SLCOs and the progression to castration-resistant prostate cancer (CRPC).Methods:We studied the progression to CRPC for the SLCO1B3 rs4149117 and SLCO2B1 rs12422149 genotypes in 87 prostate cancer patients who received androgen deprivation therapy (ADT). Data were analyzed using the χ 2 test, Kaplan-Meier survival analysis and Cox proportional hazard model.Results:SLCO3B1 genotypes were not significantly associated with the time to progression (TTP); however, patients carrying the active androgen transport SLCO2B1 genotype (GG allele) exhibited a median TTP that was 7 months shorter than that of patients with impaired androgen-transporting activity SLCO2B1 polymorphisms (GA/AA alleles) (10.0 vs 17.0 months, P=0.004). Active androgen transport genotypes of SLCO2B1 (GG allele) occurred more frequently in African and Caucasian populations than in Japanese and Han Chinese populations (P<0.001).Conclusions:These data suggest that SLCO2B1 rs12422149 variants could provide prognostic value for prostate cancer patients treated with ADT and influence ethnic differences in response to ADT. Active androgen import may be one of the underlying mechanisms of resistance to ADT, and androgen-transporting systems could provide novel biomarkers and targets for CRPC treatment. © 2013 Macmillan Publishers Limited All rights reserved. Source


Bui H.T.T.,University of Occupational and Environmental Health Japan | Fujimoto N.,University of Occupational and Environmental Health Japan | Kubo T.,University of Occupational and Environmental Health Japan | Inatomi H.,Munakata Suikoukai General Hospital | Matsumoto T.,University of Occupational and Environmental Health Japan
Cancer Investigation | Year: 2014

A variety of carcinogens are excreted in urine and may be actively transported by organic anion-transporting polypeptides that encoded by SLCOs. In this study, we evaluated whether single nucleotide polymorphisms (SNPs) in SLCO1B1, SLCO2B1, and SLCO1B3 are associated with bladder cancer susceptibility. Our results, for the first time, indicated that polymorphisms of SLCO1B1 rs2306283 might be associated with bladder cancer risk. Therefore, SNPs in SLCO1B1 may be potential biomarkers for assessing the risk of bladder cancer. © 2014 Informa Healthcare USA, Inc. Source


Ikko T.,Munakata Suikoukai General Hospital | Hisato I.,Munakata Suikoukai General Hospital | Fujimoto N.,University of Occupational and Environmental Health Japan | Matsumoto T.,University of Occupational and Environmental Health Japan
Nishinihon Journal of Urology | Year: 2010

We report the case of a 10-year-old boy with heterochronic occurrence of bilateral torsion of the appendix testis. He visited our hospital complaining of left scrotal pain. Since testicular torsion was suspected, an emergency operation was performed, and torsion of the left appendix testis was recognized. Nine months later, he again visited our hospital, due to right scrotal pain. We then suspected testicular torsion, but during surgery right torsion of the appendix testis was found. Bilateral torsion of the appendix testis is extremely uncommon and our case is only the 5th case to be reported in Japan. Source


Sakamoto T.,Kyushu University | Kakino T.,Kyushu University | Sakamoto K.,Kyushu University | Tobushi T.,Iizuka Hospital. | And 8 more authors.
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2015

Baroreflex modulates both the ventricular and vascular properties and stabilizes arterial pressure (AP). However, how changes in those mechanical properties quantitatively impact the dynamic AP regulation remains unknown. We developed a framework of circulatory equilibrium, in which both venous return and cardiac output are expressed as functions of left ventricular (LV) end-systolic elastance (Ees), heart rate (HR), systemic vascular resistance (R), and stressed blood volume (V). We investigated the contribution of each mechanical property using the framework of circulatory equilibrium. In six anesthetized dogs, we vascularly isolated carotid sinuses and randomly changed carotid sinus pressure (CSP), while measuring the LV Ees, aortic flow, right and left atrial pressure, and AP for at least 60 min. We estimated transfer functions from CSP to Ees, HR, R, and V in each dog. We then predicted these parameters in response to changes in CSP from the transfer functions using a data set not used for identifying transfer functions and predicted changes in AP using the equilibrium framework. Predicted APs matched reasonably well with those measured (r2= 0.85–0.96, P < 0.001). Sensitivity analyses indicated that Ees and HR (ventricular properties) accounted for 14 ± 4 and 4 ± 2%, respectively, whereas R and V (vascular properties) accounted for 32 ± 4 and 39 ± 4%, respectively, of baroreflex-induced AP regulation. We concluded that baroreflex-induced dynamic AP changes can be accurately predicted by the transfer functions from CSP to mechanical properties using our framework of circulatory equilibrium. Changes in the vascular properties, not the ventricular properties, predominantly determine baroreflex-induced AP regulation. © 2015 the American Physiological Society. Source


Amako M.,Kurume University | Yamamoto Y.,Kyoaikai Tobata Kyoritsu Hospital | Nakamura K.,Kyoaikai Tobata Kyoritsu Hospital | Tobinaga S.,Kurume University | And 6 more authors.
Kurume Medical Journal | Year: 2011

To improve our ability to visualize the Adamkiewicz artery (AKA), we developed a modified intravenous CT angiography technique, which we refer to as right atrial CT (RA-CT) angiography. In this study, AKA detection rate and visualization of the arterial continuity from the aorta to the anterior spinal cord artery (ASA) was evaluated using RA-CT angiography. We performed RA-CT angiography in 110 patients with abdominal, thoracic descending, or thoracoabdominal aortic aneurysms. In RA-CT angiography, contrast medium with a high iodine concentration (370 mg/dl) was injected twice into the right atrium at a high injection rate (8.0 ml/sec), and two CT scans, starting at 20 sec after the first injection and at 35 sec after the second injection, respectively, were performed. All CT images were obtained using an 8- or 16-detector CT scanner at a slice thickness of 0.625 mm. The AKA was defined as the largest radiculomedullary artery with a characteristic hairpin turn, and with continuity from the aorta to the ASA. The AKA with hairpin turn was detected in all patients (100%), and continuity from the aorta to the ASA was confirmed in 99 of the 110 patients (90.0%). The AKA arose between Th8 and L1 in 86 of these patients (86.8%), and originated from the left side in 71 patients (71.7%). RA-CT angiography may be useful for visualizing the AKA and the arterial continuity from the aorta to the ASA in patients with aortic aneurysm, although the use of more advanced CT machines will provide safe and easy identification of the AKA and arterial continuity with a small amount of contrast medium and a single scan. Source

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