Mashhad, Iran
Mashhad, Iran
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Assali A.,Biotechnology Research Center | Assali A.,Avicenna Research Institute | Assali A.,Payame Noor University | Behravan J.,Biotechnology Research Center | And 14 more authors.
Asian Biomedicine | Year: 2010

Background: There are reported associations between a polymorphism of the angiotensin II type 1 receptor (AT1R/A1166C) gene and coronary artery disease (CAD), hypertension, and myocardial infarction in some populations. Objective: Investigate the association between A1166C polymorphism and CAD in an Iranian population. Methods: Four hundred and thirteen patients with suspected CAD were recruited. Based on coronary angiography, the patients were classified into CAD+ (n=315) and CAD- (n=98) groups defined as >50% and <50% stenosis of any major coronary artery, respectively. One hundred and thirty-five healthy subjects were also recruited as the control group. The AT1R polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) based method. Results: A higher frequency of the AC and CC genotypes and lower frequency of the AA genotype was observed in both CAD+ and CAD- groups, compared with the control group (p <0.05). CAD+ and CAD- groups also had a higher frequency of the C allele than controls (p <0.01). There was no significant difference in genotype and allele frequencies between hypertensive and non-hypertensive patients (p > 0.05). In addition, the AT1R genotype frequencies did not differ significantly among different subgroups of CAD+ patients, based on the number of affected coronary vessels (p >0.05). Conclusion: The frequency AT1R/A1166C polymorphism was higher among patients with some degrees of coronary stenosis who are candidates of coronary angiography.

Mosallaei N.,Mashhad University of Medical Sciences | Banaee T.,Eye Research Center | Farzadnia M.,MUMS | Malaekeh-Nikouei B.,Mashhad University of Medical Sciences | Malaekeh-Nikouei B.,Nanotechnology Research Center
Current Eye Research | Year: 2012

Aim: Cyclosporine A (CyA) is an anti inflammatory drug which modulates immune system. We prepared two liposomal formulations of CyA for ophthalmic administration. In the present study, the safety of these formulations was tested in rabbits. Materials and methods: Fusogenic and positively charged liposomes were prepared by solvent evaporation method. CyA concentration in ophthalmic preparations was 0.2% w/v. Twenty New Zealand albino rabbits (40 eyes) were divided into two groups. Right eyes were treated and left eyes served as control. Eyes were examined clinically in 1, 3, 7, 14 and 28th days of the study. Eleven eyes were enucleated for pathological evaluation at the end of the study. Results: Mean size and charge of positively charged and fusogenic liposomes were 110.7±1.5 and 114.9±15.2 nm; 19.0±2.2 and 2.5±0.5 mV, respectively. Clinically, there were transient conjunctival injections and corneal epithelial defects in a few cases which were not limited to the treated eyes. Positively charged liposomes caused conjunctival injection in two cases, while this complication occurred in only one eye after administration of fusogenic liposomes. Histopathological examination revealed the presence of follicular conjunctivitis in two eyes with conjunctival injection. Inflammation in cases received the fusogenic form of the drug was mild and non-specific. Conclusions: The results of this study suggest that fusogenic liposomal preparation of CyA is safe and can be useful for future studies. © 2012 Informa Healthcare USA, Inc.

Azarpazhooh M.R.,Mashhad University of Medical Sciences | Etemadi M.M.,Mashhad University of Medical Sciences | Donnan G.A.,University of Melbourne | Mokhber N.,Avicenna Hospital | And 8 more authors.
Stroke | Year: 2010

BACKGROUND AND PURPOSE-: The epidemiology of stroke and its subtypes in the Middle East is unclear. Most previous studies have been performed in Western countries, and incidence rates are unlikely to apply in the Middle East. We aimed to determine the incidence of stroke in Mashhad, northeastern Iran. METHODS-: During a 12-month period (2006-2007), we prospectively ascertained all strokes occurring in a population of 450 229. Multiple overlapping sources were used to identify people with stroke. A large number of volunteers assisted in finding stroke patients not admitted to hospital. Potential cases were reviewed by a group of stroke experts before inclusion. RESULTS-: A total of 624 first-ever strokes occurred during the study period, 98.4% undergoing imaging. Despite a relatively low crude annual incidence rate of first-ever stroke FES (139; 95% CI, 128 to 149) per 100 000 residents, rates adjusted to the European population aged 45 to 84 years were higher than in most other countries: 616 (95% CI, 567 to 664) for ischemic stroke, 94 (95% CI, 75 to 113) for intracerebral hemorrhage, and 12 (95% CI, 5 to 19) for subarachnoid hemorrhage. Age-specific stroke incidence was higher in younger patients than is typically seen in Western countries. Comparison of age-specific incidence rates between regions revealed that stroke in Mashhad occurs approximately 1 decade earlier than in Western countries. CONCLUSIONS-: The results of this study provide evidence that the incidence of stroke in Iran is considerably greater than in most Western countries, with stroke occurring at younger ages. Ischemic stroke incidence was also considerably greater than reported in other regions. © 2009 American Heart Association, Inc.

Darbandi S.,Mashhad University of Medical Sciences | Darbandi M.,Mashhad University of Medical Sciences | Mokarram P.,Shiraz University of Medical Sciences | Owji A.-A.,SUMS | And 13 more authors.
Alternative Therapies in Health and Medicine | Year: 2013

Background The prevalence of obesity, a major public health problem, is increasing in many countries, including Iran. Leptin, a peptide hormone that is released from adipocytes, is a major factor in appetite regulation. Levels of plasma leptin increase with increased body fat mass (BFM). Research has found acupuncture to be effective both in weight loss and suppression of appetite. Although a few studies have reported the effect of body and ear acupuncture on leptin levels, researchers have performed few studies on the effect of body electroacupuncture in humans. Objective The research team examined the effects of body electroacupuncture and a low-calorie diet on plasma leptin in obese and overweight individuals with an excess (phlegm-dampness or phlegm-heat) or deficiency (spleen/ stomach qi deficiency or primary qi deficiency) pattern according to Chinese medicine. Design The research team randomly assigned participants to one of two groups, intervention or control. Setting This study occurred in the nutritional clinic at Ghaem Hospital in Mashhad, Iran. Participants Participants were individuals (N = 86) between 18 and 65 years of age with body mass indexes (BMI) between 25 and 45 kg/m2. Intervention The intervention group (n = 47) received actual electroacupuncture, and the control group (n = 47) received sham acupuncture. Both groups consumed a low-calorie diet for 6 weeks. Outcome Measures The research team measured plasma leptin, BFM, body weight (BW), and BMI before and after treatment. Results For participants in the intervention group with both the excess and the deficiency patterns, the research team found a significant reduction in plasma leptin (24.96%, P =.001) and BFM (8.29%, P =.001). In the control group, the team found a less significant reduction in leptin and BFM. The difference between the two groups was significant for leptin (P =.03) but not for BFM (P =.8). Conclusions While body electroacupuncture with a low-calorie diet can reduce plasma leptin concentration, the mechanism will require further clarification.

Fazlinezhad A.,Mashhad University of Medical Sciences | Khadem Rezaeian M.,MUMS | Yousefzadeh H.,Islamic Azad University at Mashhad | Ghaffarzadegan K.,Moayed laboratory | Khajedaluee M.,MUMS
Clinical Medicine Insights: Cardiology | Year: 2011

Aims: This study investigated the prognostic value of B type natriuretic peptide (BNP) in acute myocardial infarction (AMI) patients and its relation with left ventricular function and post-myocardial infarction complications. Methods: In this cross-sectional study, plasma BNP level was measured for 42 consecutive patients (mean± SD: 61.6± 10.85 years old) with acute ST elevation myocardial infarction (MI) and 42 healthy, age and gender matched subjects. Result: BNP level in AMI patients were significantly higher than control group (P < 0.001). Regarding to infarct location, the highest BNP level measured in inferoposterior MI (BNP=4436.63± 6188.159 pg/ml) and the lowest one indicated in standalone inferior MI (BNP=598.83± 309.867 pg/ml (P=0.071). There was significant reverse relation between BNP and EF (P=0.006, OR=-0.47) and a significant relationship between BNP and killip classification (P=0.036). There was no significant relation between diastolic and rightventricular function and BNP level (P=0.61, P=0.21). The highest BNP level was detected in LV septal rupture and false aneurysm (P=0.02) and in ventricular tachycardia, but without significant relationship (P=0.25). Conclusion: After the onset of AMI, BNP blood level can be used as an important predictor for left ventricular dysfunction, killip classification, early mechanical complications and cardiac death. © the author(s), publisher and licensee Libertas Academica Ltd.

Bahrami-Taghanaki H.,Mashhad University of Medical Sciences | Liu Y.,Beijing University of Chinese Medicine | Aziz H.,MUMS | Khorsand A.,MUMS | And 3 more authors.
Alternative Therapies in Health and Medicine | Year: 2014

Background • Chronic low-back pain (cLBP) is a common condition throughout the world, and acupuncture is widely sought for treatment. As clinical evidence for the benefits of acupuncture grows, acupuncture for cLBP is receiving increased recognition and acceptance by both patients and professionals. Time method acupuncture has been previously researched with respect to chronic gastritis. Objective • For individuals with cLBP in the current study, the research team examined the efficacy of adding confluent acupoints, related to the daytime period in time method acupuncture, to regular acupuncture and also evaluated the persistence of the benefits of such acupuncture in comparison with regular acupuncture. Design • The study was a randomized, controlled trial (RCT). Setting • The setting was an outpatient clinic of the Dongzhimen Hospital in Beijing, China. Participants • Participants were Chinese men and women with cLBP. Intervention • Sixty participants were randomly divided into 2 groups to receive acupuncture. The control group received a treatment that followed a routine acupuncture (RA) protocol, while the intervention group received a treatment that followed an RA protocol plus acupuncture in confluent points related to time (TA). Outcome Measures • The research team measured the change in participants’ scores using the visual analogue scale (VAS), the number of therapy sessions needed, the number of days that participants were absent from work during the treatment period and at 12 wk posttreatment, and the number of pain relapses between the end of treatment and the 4- and 12-wk follow-ups. Results • VAS scores decreased from 69.6 ± 7.9 to 11.8 ± 4.9 in the intervention group compared with a decrease from 69.2 ± 8.0 to 15.7 ± 10.0 in the control group (P =.001). The intervention group received fewer therapy sessions (8.1 ± 2.0) than did the control group (10.1 ± 2.0, P <.001). Compared with the controls, the intervention group showed fewer days absent from work (0.5 vs 1.4; P =.03) and fewer pain relapses (4.0 vs 7.0; P =.04) at the 12-wk follow-up. In the 2 groups combined, VAS decreased from 69.4 ± 7.9 before the first session of acupuncture to 13.8 ± 8.0 after the last session (P <.001), and the number of therapy sessions needed for pain relief was 9.1 ± 2.2. Conclusion Accompanying routine acupuncture with time method acupuncture can enhance the efficacy of treatment and the persistence of its benefits in individuals with cLBP. © 2014, InnoVision Communications. All rights reserved.

Boskabadi H.,Mashhad University of Medical Sciences | Maamouri G.,MUMS | Mafinejad S.,Fellowship of Neonatology
Macedonian Journal of Medical Sciences | Year: 2011

Background: Prolonged rupture of membranes (PROM) is a common and significant cause of preterm labor and has a major impact on neonatal morbidity and mortality. The aim of this study was to determine maternal risk factors and the prevalence rate of neonatal complications following PROM. This study also detected the role of maternal antimicrobial treatment on neonatal complications. Methods: This cross-sectional study was performed at Ghaem hospital, Mashhad, Iran; from March 2008 to April 2010 to evaluate newborns outcome that were born from mothers with prolonged premature rupture of membranes (PROM> 18 hours). Maternal risk factors, antibiotic administration and its influences on neonatal complications were evaluated. Eligible infants were categorized into group I (symptomatic infants), II (mother with chorioamnionitis) and III (asymptomatic infants). Results: 150 infants were included in the study. 12 (7.7%) infants had definitive infections (meningitis, sepsis, pneumonia), 101(67%) infants were premature and 88(58.6%) infants had mothers with a history of antibiotic intake. Maternal risk factors were reported in the following order: previous PROM (10%), addiction (8%), high urinary tract infection (5/3%), diabetes (4.7%), placenta abruption (4.7%), preeclampsia (3/3%) and cercelage (2%). Neonatal complications related with PROM were prematurity (67.3%), respiratory distress syndrome (22.6%), asphyxia (8.6%), meningitis (5.2%), sepsis (4%), pneumonia (1.3%) and death (4.6%). History of antibiotic administration to mothers with PROM was negative in four babies with sepsis and one with meningitis. Conclusion: The most common complication of PROM was prematurity and its side effects, but infection is the most important modifiable complication. Although antimicrobial treatment of women with a history of PROM improves neonatal outcome through reducing neonatal sepsis and respiratory distress syndrome (RDS), but the incidence rate of meningitis and pneumonia may be increased. © Boskabadi H.

Pezeshkpoor F.,Mashhad University of Medical Sciences | Hosseini R.F.,Mashhad University of Medical Sciences | Rafatpanah H.,Mashhad University of Medical Sciences | Shakerian B.,Mashhad University of Medical Sciences | And 6 more authors.
Iranian Journal of Allergy, Asthma and Immunology | Year: 2012

Chronic Idiopathic Urticaria is defined as recurrent hives occurring for at least 6 weeks. In the majority of cases, there is no identifiable underlying etiology despite extensive evaluation. A subset of these patients is classified as having autoimmune urticaria defined by the presence of a functional IgG antibody to the " subunit of the high-affinity IgE receptor (FceRIa) or to IgE. The aim of this study was to evaluate the effects of the drug atorvastatin in patients with chronic urticaria compared to the placebo. In this single-blind study, 50 patients suffering from chronic urticaria (15-45 years old) were selected and divided into two groups by simple randomization method. The first group was treated with atorvastatin and antihistamines and the second group (control group) was treated with placebo and antihistamines for 3 months. Urticaria severity was measured by score index, before and after the treatment course: ASST (Autologous serum skin test) was performed for all patients and sera were collected to measure cytokines. In cases, IL-5 decreased and IL-10 increased after treatment compared to the time point before treatment (p<0.05). All patients with severe utricaria according our scoring, had positive ASST. The patients with severe urticaria identified by urticaria score and ASST positivity had chronic idiopathic urticaria. By prescribing the Atorvastatin plus antihistamines in severe and resistant forms of urticaria, the use of more toxic medications like cytotoxic drugs may be avoided. Copyright© 2012, Iranian Journal of Allergy, Asthma and Immunology. All rights reserved.

Mazlom S.R.,MUMS | Esmaily H.,MUMS | Nezafati M.H.,MUMS | Hajiabadi F.,MUMS
Life Science Journal | Year: 2013

The main objective of coronary bypass is quality of life improvement,so, it is necessary to identify and control the factor that effect on it. This study aimed to identify relationship between post operative quality of recovery after 72h and quality of life 3 month after coronary by pass. This descriptive correlational study was conducted on 72 patients underwent coronary bypass at Mashhad Imam Reza hospital. Data were collected 24h before surgery and 72 and 3 month after surgery using demographic data form and short form 36 for quality of life assessment and Quality of recovery 40 for quality of recovery assessment. A direct significant correlation was found between quality of recovery 72h after surgery and quality of life 3 month after surgery (p<0.001 r=0.91). General linear model result showed that quality of recovery 72h after surgery was the most important predictive index for quality of life level 3 month after surgery (p<0.001 r=0.78) quality of recovery 72h after surgery was an important predictive index for next months quality of life after operation so, recovery care improvement could be a proper approach for quality of life improvement after surgery.

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