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Mashhad, Iran

Pezeshkpoor F.,Mashhad University of Medical Sciences | Hosseini R.F.,Mashhad University of Medical Sciences | Rafatpanah H.,Mashhad University of Medical Sciences | Shakerian B.,Mashhad University of Medical Sciences | And 6 more authors.
Iranian Journal of Allergy, Asthma and Immunology | Year: 2012

Chronic Idiopathic Urticaria is defined as recurrent hives occurring for at least 6 weeks. In the majority of cases, there is no identifiable underlying etiology despite extensive evaluation. A subset of these patients is classified as having autoimmune urticaria defined by the presence of a functional IgG antibody to the " subunit of the high-affinity IgE receptor (FceRIa) or to IgE. The aim of this study was to evaluate the effects of the drug atorvastatin in patients with chronic urticaria compared to the placebo. In this single-blind study, 50 patients suffering from chronic urticaria (15-45 years old) were selected and divided into two groups by simple randomization method. The first group was treated with atorvastatin and antihistamines and the second group (control group) was treated with placebo and antihistamines for 3 months. Urticaria severity was measured by score index, before and after the treatment course: ASST (Autologous serum skin test) was performed for all patients and sera were collected to measure cytokines. In cases, IL-5 decreased and IL-10 increased after treatment compared to the time point before treatment (p<0.05). All patients with severe utricaria according our scoring, had positive ASST. The patients with severe urticaria identified by urticaria score and ASST positivity had chronic idiopathic urticaria. By prescribing the Atorvastatin plus antihistamines in severe and resistant forms of urticaria, the use of more toxic medications like cytotoxic drugs may be avoided. Copyright© 2012, Iranian Journal of Allergy, Asthma and Immunology. All rights reserved.

Boskabadi H.,Mashhad University of Medical Sciences | Maamouri G.,MUMS | Mafinejad S.,Fellowship of Neonatology
Macedonian Journal of Medical Sciences | Year: 2011

Background: Prolonged rupture of membranes (PROM) is a common and significant cause of preterm labor and has a major impact on neonatal morbidity and mortality. The aim of this study was to determine maternal risk factors and the prevalence rate of neonatal complications following PROM. This study also detected the role of maternal antimicrobial treatment on neonatal complications. Methods: This cross-sectional study was performed at Ghaem hospital, Mashhad, Iran; from March 2008 to April 2010 to evaluate newborns outcome that were born from mothers with prolonged premature rupture of membranes (PROM> 18 hours). Maternal risk factors, antibiotic administration and its influences on neonatal complications were evaluated. Eligible infants were categorized into group I (symptomatic infants), II (mother with chorioamnionitis) and III (asymptomatic infants). Results: 150 infants were included in the study. 12 (7.7%) infants had definitive infections (meningitis, sepsis, pneumonia), 101(67%) infants were premature and 88(58.6%) infants had mothers with a history of antibiotic intake. Maternal risk factors were reported in the following order: previous PROM (10%), addiction (8%), high urinary tract infection (5/3%), diabetes (4.7%), placenta abruption (4.7%), preeclampsia (3/3%) and cercelage (2%). Neonatal complications related with PROM were prematurity (67.3%), respiratory distress syndrome (22.6%), asphyxia (8.6%), meningitis (5.2%), sepsis (4%), pneumonia (1.3%) and death (4.6%). History of antibiotic administration to mothers with PROM was negative in four babies with sepsis and one with meningitis. Conclusion: The most common complication of PROM was prematurity and its side effects, but infection is the most important modifiable complication. Although antimicrobial treatment of women with a history of PROM improves neonatal outcome through reducing neonatal sepsis and respiratory distress syndrome (RDS), but the incidence rate of meningitis and pneumonia may be increased. © Boskabadi H.

Fazlinezhad A.,Mashhad University of Medical Sciences | Khadem Rezaeian M.,MUMS | Yousefzadeh H.,Islamic Azad University at Mashhad | Ghaffarzadegan K.,Moayed laboratory | Khajedaluee M.,MUMS
Clinical Medicine Insights: Cardiology | Year: 2011

Aims: This study investigated the prognostic value of B type natriuretic peptide (BNP) in acute myocardial infarction (AMI) patients and its relation with left ventricular function and post-myocardial infarction complications. Methods: In this cross-sectional study, plasma BNP level was measured for 42 consecutive patients (mean± SD: 61.6± 10.85 years old) with acute ST elevation myocardial infarction (MI) and 42 healthy, age and gender matched subjects. Result: BNP level in AMI patients were significantly higher than control group (P < 0.001). Regarding to infarct location, the highest BNP level measured in inferoposterior MI (BNP=4436.63± 6188.159 pg/ml) and the lowest one indicated in standalone inferior MI (BNP=598.83± 309.867 pg/ml (P=0.071). There was significant reverse relation between BNP and EF (P=0.006, OR=-0.47) and a significant relationship between BNP and killip classification (P=0.036). There was no significant relation between diastolic and rightventricular function and BNP level (P=0.61, P=0.21). The highest BNP level was detected in LV septal rupture and false aneurysm (P=0.02) and in ventricular tachycardia, but without significant relationship (P=0.25). Conclusion: After the onset of AMI, BNP blood level can be used as an important predictor for left ventricular dysfunction, killip classification, early mechanical complications and cardiac death. © the author(s), publisher and licensee Libertas Academica Ltd.

Bahrami-Taghanaki H.,Mashhad University of Medical Sciences | Liu Y.,Beijing University of Chinese Medicine | Aziz H.,MUMS | Khorsand A.,MUMS | And 3 more authors.
Alternative Therapies in Health and Medicine | Year: 2014

Background • Chronic low-back pain (cLBP) is a common condition throughout the world, and acupuncture is widely sought for treatment. As clinical evidence for the benefits of acupuncture grows, acupuncture for cLBP is receiving increased recognition and acceptance by both patients and professionals. Time method acupuncture has been previously researched with respect to chronic gastritis. Objective • For individuals with cLBP in the current study, the research team examined the efficacy of adding confluent acupoints, related to the daytime period in time method acupuncture, to regular acupuncture and also evaluated the persistence of the benefits of such acupuncture in comparison with regular acupuncture. Design • The study was a randomized, controlled trial (RCT). Setting • The setting was an outpatient clinic of the Dongzhimen Hospital in Beijing, China. Participants • Participants were Chinese men and women with cLBP. Intervention • Sixty participants were randomly divided into 2 groups to receive acupuncture. The control group received a treatment that followed a routine acupuncture (RA) protocol, while the intervention group received a treatment that followed an RA protocol plus acupuncture in confluent points related to time (TA). Outcome Measures • The research team measured the change in participants’ scores using the visual analogue scale (VAS), the number of therapy sessions needed, the number of days that participants were absent from work during the treatment period and at 12 wk posttreatment, and the number of pain relapses between the end of treatment and the 4- and 12-wk follow-ups. Results • VAS scores decreased from 69.6 ± 7.9 to 11.8 ± 4.9 in the intervention group compared with a decrease from 69.2 ± 8.0 to 15.7 ± 10.0 in the control group (P =.001). The intervention group received fewer therapy sessions (8.1 ± 2.0) than did the control group (10.1 ± 2.0, P <.001). Compared with the controls, the intervention group showed fewer days absent from work (0.5 vs 1.4; P =.03) and fewer pain relapses (4.0 vs 7.0; P =.04) at the 12-wk follow-up. In the 2 groups combined, VAS decreased from 69.4 ± 7.9 before the first session of acupuncture to 13.8 ± 8.0 after the last session (P <.001), and the number of therapy sessions needed for pain relief was 9.1 ± 2.2. Conclusion Accompanying routine acupuncture with time method acupuncture can enhance the efficacy of treatment and the persistence of its benefits in individuals with cLBP. © 2014, InnoVision Communications. All rights reserved.

Azarpazhooh M.R.,Mashhad University of Medical Sciences | Etemadi M.M.,Mashhad University of Medical Sciences | Donnan G.A.,University of Melbourne | Mokhber N.,Avicenna Hospital | And 9 more authors.
Stroke | Year: 2010

BACKGROUND AND PURPOSE-: The epidemiology of stroke and its subtypes in the Middle East is unclear. Most previous studies have been performed in Western countries, and incidence rates are unlikely to apply in the Middle East. We aimed to determine the incidence of stroke in Mashhad, northeastern Iran. METHODS-: During a 12-month period (2006-2007), we prospectively ascertained all strokes occurring in a population of 450 229. Multiple overlapping sources were used to identify people with stroke. A large number of volunteers assisted in finding stroke patients not admitted to hospital. Potential cases were reviewed by a group of stroke experts before inclusion. RESULTS-: A total of 624 first-ever strokes occurred during the study period, 98.4% undergoing imaging. Despite a relatively low crude annual incidence rate of first-ever stroke FES (139; 95% CI, 128 to 149) per 100 000 residents, rates adjusted to the European population aged 45 to 84 years were higher than in most other countries: 616 (95% CI, 567 to 664) for ischemic stroke, 94 (95% CI, 75 to 113) for intracerebral hemorrhage, and 12 (95% CI, 5 to 19) for subarachnoid hemorrhage. Age-specific stroke incidence was higher in younger patients than is typically seen in Western countries. Comparison of age-specific incidence rates between regions revealed that stroke in Mashhad occurs approximately 1 decade earlier than in Western countries. CONCLUSIONS-: The results of this study provide evidence that the incidence of stroke in Iran is considerably greater than in most Western countries, with stroke occurring at younger ages. Ischemic stroke incidence was also considerably greater than reported in other regions. © 2009 American Heart Association, Inc.

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