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Bozzola E.,Pediatric and Infectious Diseases Unit | Bozzola M.,University of Pavia | Krzysztofiak A.,Pediatric and Infectious Diseases Unit | Tozzi A.E.,Multifactorial Disease and Complex Phenotype Research Area | And 2 more authors.
International Journal of Molecular Sciences | Year: 2016

Even if varicella is generally considered a harmless disease in childhood, severe complications may occur. We examined varicella skin complications (VSCs) in hospitalized immunologically healthy children, over a nine-year period. We also systematically analyzed previous reports to calculate the rate of VSCs in the literature. VSCs occurred in 16.4% of children hospitalized for varicella. This figure is in accordance with the literature, as the range of VSCs was 2.6%–41.2%. Skin complications may represent determinants of hospitalization and of other indirect costs in young children. © 2016 by the authors; licensee MDPI, Basel, Switzerland. Source

Savarese I.,Neonatal Intensive Care Unit | Balestri M.,Neurology Unit | Piersigilli F.,Neonatal Intensive Care Unit | Giliberti P.,Neonatal Intensive Care Unit | And 7 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: Therapeutic hypothermia (TH) started within six hours from birth has been shown to improve neurodevelopmental outcomes in newborns with moderate-to-severe hypoxic-ischemic encephalopathy. Methods: Twenty-nine consecutive newborns treated with whole body cooling at the Bambino Gesú Children's Hospital between March 2011 and December 2012 were included in this study. All infants were out-born neonates. Passive cooling was always started at the birth center and continued during transportation. Pre- and post-transport risk index of physiological stability (TRIPS) scores were calculated for each patient to evaluate the impact of the transportation. Magnetic resonance imaging (MRI) was performed within 10 days of life to investigate the presence of brain injury. Results: Among the 26 survivors, 14 had no detectable lesions and 12 presented with brain injury on MRI. Four babies presented with cerebral bleeding. Babies with cerebral hemorrhage had a worse pre-transport TRIPS score, but among these neonates no worsening between pre and post-transport score was registered. Conclusion: The presence of cerebral hemorrhagic lesions seemed to be related to the initial clinical conditions of the baby rather than to the transport itself. Our data confirm that TH performed in an out-born center is efficient and safe. © 2015 Taylor & Francis. Source

D'Ambrosio A.,Multifactorial Disease and Complex Phenotype Research Area | Agricola E.,Multifactorial Disease and Complex Phenotype Research Area | Russo L.,Multifactorial Disease and Complex Phenotype Research Area | Gesualdo F.,Multifactorial Disease and Complex Phenotype Research Area | And 6 more authors.
PLoS ONE | Year: 2015

Background: The risk of adverse pregnancy outcomes can be minimized through the adoption of healthy lifestyles before pregnancy by women of childbearing age. Initiatives for promotion of preconception health may be difficult to implement. Internet can be used to build tailored health interventions through identification of the public's information needs. To this aim, we developed a semi-automatic web-based system for monitoring Google searches, web pages and activity on social networks, regarding preconception health. Methods: Based on the American College of Obstetricians and Gynecologists guidelines and on the actual search behaviors of Italian Internet users, we defined a set of keywords targeting preconception care topics. Using these keywords, we analyzed the usage of Google search engine and identified web pages containing preconception care recommendations. We also monitored how the selected web pages were shared on social networks. We analyzed discrepancies between searched and published information and the sharing pattern of the topics. Results: We identified 1,807 Google search queries which generated a total of 1,995,030 searches during the study period. Less than 10% of the reviewed pages contained preconception care information and in 42.8% information was consistent with ACOG guidelines. Facebook was the most used social network for sharing. Nutrition, Chronic Diseases and Infectious Diseases were the most published and searched topics. Regarding Genetic Risk and Folic Acid, a high search volume was not associated to a high web page production, while Medication pages were more frequently published than searched. Vaccinations elicited high sharing although web page production was low; this effect was quite variable in time. Conclusion: Our study represent a resource to prioritize communication on specific topics on the web, to address misconceptions, and to tailor interventions to specific populations. © 2015 D'Ambrosio et al. Source

Agricola E.,Multifactorial Disease and Complex Phenotype Research Area | Gesualdo F.,Multifactorial Disease and Complex Phenotype Research Area | Carloni E.,Multifactorial Disease and Complex Phenotype Research Area | D'Ambrosio A.,Multifactorial Disease and Complex Phenotype Research Area | And 4 more authors.
Reproductive Health | Year: 2016

Background: Paternal preconception risk factors such as smoking, exposure to environmental substances, medication use, overweight and advanced age correlate with the occurrence of malformations and birth defects in the offspring. Nonetheless, the prevalence of risk factors for adverse pregnancy outcomes in the male population has been scarcely investigated and no report on preconception interventions targeting prospective fathers is available. We conducted a web-based survey to measure the prevalence of paternal preconception risk factors for adverse pregnancy outcomes in an Italian population of Internet users. Methods: Prospective or expectant fathers were enrolled during a four-week period through two of the main Italian web-sites dedicated to preconception, pregnancy, childhood and family care. Participants filled in a web questionnaire regarding preconception risk factors for adverse pregnancy outcomes. Logistic regression analysis was used to explore the predictors of paternal preconception risk factors. Results: We enrolled 131 prospective and 205 expectant fathers. More than half of the total participants used medications during the preconception period, 35 % were smokers and 8 % were obese. Exposure to environmental substances was declared by almost 20 % of the participants, with the group including pesticides/herbicides/professional paints being the most prevalent. More than a half of the study sample included men aged over 35 years. According to the multivariate analysis, smoking and exposure to environmental toxics were less frequent among individuals with a university degree (respectively: OR = 0.52; 95 % CI 0.32-0.84; OR = 0.52; 95 % CI 0.29-0.93). Paternal obesity and medication use in the preconception period were not associated with any of the independent variables. Conclusions: The prevalence of preconception risk factors among male population should not be neglected when planning preconception interventions, confirming that preconception health must be focused on the couple, rather than on women only. © 2016 Agricola et al. Source

Gesualdo F.,Multifactorial Disease and Complex Phenotype Research Area | Stilo G.,University of Rome La Sapienza | D'Ambrosio A.,Multifactorial Disease and Complex Phenotype Research Area | Carloni E.,Multifactorial Disease and Complex Phenotype Research Area | And 4 more authors.
PLoS ONE | Year: 2015

Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC). We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case definition of ARC and those reporting the name of an antihistamine drug. In order to increase the sensitivity of the system, we applied an algorithm aimed at automatically identifying jargon expressions related to medical terms. We compared weekly Twitter trends with National Allergy Bureau weekly pollen counts derived from US stations, and found a high correlation of the sum of the total pollen counts from each stations with tweets reporting ARC symptoms (Pearson's correlation coefficient: 0.95) and with tweets reporting antihistamine drug names (Pearson's correlation coefficient: 0.93). Longitude and latitude of the pollen stations affected the strength of the correlation. Twitter and other social networks may play a role in allergic disease surveillance and in signaling drug consumptions trends. © 2015 Gesualdo et al. Source

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