Andersen L.P.H.,Copenhagen University |
Werner M.U.,Multidisciplinary Pain Center 7612 |
Rosenberg J.,Copenhagen University |
Gogenur I.,Copenhagen University
Anaesthesia | Year: 2014
We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I2 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements. © 2014 The Association of Anaesthetists of Great Britain and Ireland.