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Mateen A.,Multan Institute of Nuclear Medicine and Radiotherapy MINAR | Javed A.A.,Nishtar Hospital | Masood A.I.,Nishtar Hospital
Chinese-German Journal of Clinical Oncology | Year: 2012

Objective: Hepatocellular carcinoma (HCC) is among the most common and rapidly increasing cancers in Pakistan. There is currently no standard management for advanced HCC. The aim of the study was to assess response rate and toxicity of concomitant gemcitabine and external radiation therapy (ERT) in locally advanced HCC. Methods: Sixty patients were enrolled. Gemcitabine, 70 mg/m 2 was given weekly during ERT. ERT was delivered with 60Co beam up to 30.6 Gy, 1.8 Gy/fraction. Tumor response was assessed by computed tomography (CT) at eight weeks. Complete and partial response (CR and PR), progressive and stable disease (PD and SD) were assessed. Hematological, gastrointestinal and hepatic toxicities were assessed weekly. Results: No CR was seen. PR, SD and PD were seen in 33%, 40% and 27% of patients respectively. Grade 3/4 toxicity for total leukocyte count and platelets was observed in 7% and 27% patients. Grade 3/4 toxicity for liver failure, bilirubin, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase was seen in 35%, 28%, 38%, 24% and 43% patients respectively. Conclusion: The study showed that concomitant gemcitabine and ERT is a feasible option with moderate toxicity in advanced HCC. © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012.

Keshtgar M.,University College London | Zaknun J.J.,International Atomic Energy Agency | Zaknun J.J.,University of Innsbruck | Sabih D.,Multan Institute of Nuclear Medicine and Radiotherapy MINAR | And 4 more authors.
World Journal of Surgery | Year: 2011

Background: Sentinel lymph node biopsy (SLNB) is the accepted standard of care in early-stage breast cancer and cutaneous melanoma. This technology is accurate for nodal staging and determining the prognosis of these patients. There are several randomized controlled trials confirming the accuracy of this technique and confirming its role in reducing morbidity and improving quality of life. It is also gaining increased acceptance in the management of other solid tumors. Despite the established benefits of SLNB as a minimally invasive approach for nodal staging, the procedure is still underutilized in many developing countries. Methods: The Human Health Division of the International Atomic Energy Agency (IAEA) convened advisory meetings with panels of multidisciplinary experts from different backgrounds with the remit to analyze the difficulties encountered by developing countries in establishing a successful SLNB program. The other remit of the panel was to recommend an effective program based on existing evidence that can be adapted and implemented in developing countries. The experience of some members of the panel in the training for this technique in Asia, Latin America, and Africa provided the insight required for the development of a comprehensive and structured program. The panel included recommendations on the technical aspects of the procedure, as well as a comprehensive training program, including theoretical teaching, practical training in surgical skills, laboratories, and hands-on proctored learning. Particular emphasis was placed on in-built quality assurance requirements to ensure that this powerful staging investigation is implemented with the highest possible standard in the management of cancer patients, with the lowest false negative rate. Conclusions: It is hoped that this article will be a useful resource for our colleagues planning to establish a SLNB program. © 2011 Société Internationale de Chirurgie References:.

Mahmood R.,Multan Institute of Nuclear Medicine and Radiotherapy MINAR | Parveen S.,Nishtar Medical College | Kanwal S.,Allama Iqbal Medical College
Pakistan Journal of Medical and Health Sciences | Year: 2015

Background: Infection by HBV and HCV is the most serious health problem in our country especially in the southern Punjab. Very few studies exist on incidence of this infection but they hardly reflect our general population. Aim: To find the prevalence of hepatic infection in the general population of southern Punjab. Methods: A total of 120 euthyroid patients (males: 36 Females: 84) who visited MINAR for thyroid tests during December 2010-11 were included in this study. The mean age of these persons was 30.7±.09 years (range 18-52 years). The patients with thyroid disorders and other infectious or non-infectious disease were excluded. Serum was tested for HBC and HCV detection using commercially supplied kits of HBS (One Step Test Device) and HCV (One Step Test Device) for qualitative detection of HBS or HCV. The principle of the test was rapid chromatographic immunoassay for the qualitative detection HBS and ani-HCV. T3, T4 and TSH were measured by RIA methods. Results: Out of 120 subjects 4(3.3%) were found positive for HBsAg and 18(15%) were found positive for anti-HCV. Statistical comparison of this data showed that prevalence of HCV infection was about 4 times higher than HBV infection (p=0.00028). Prevalence of HBsAg in males (8%) was significantly higher than females (1.2%; p<0.006345) whereas prevalence of HCV in males (16.7%) was not significantly different from females ((14.2%;p=0.521303). Comparison of groups of males positive for HCV and HBS showed that the incidence of HCV infection (16.7%) was significantly higher than HBS (8.33%). (p=0.0102). Similarly comparison of groups of females positive for HCV and HBS showed that the incidence of HCV infection (14.2%) was significantly higher p=0.000011) than HBS (1.2%). Conclusion: The increased level of HCV infection in our population is alarming and needs extensive studies and preventive measures in future.

Minhas F.U.A.A.,Colorado State University | Sabih D.,Multan Institute of Nuclear Medicine and Radiotherapy MINAR | Hussain M.,Pakistan Institute of Engineering and Applied Sciences
Journal of Medical Systems | Year: 2012

This paper presents a novel approach for detection of Fatty liver disease (FLD) and Heterogeneous liver using textural analysis of liver ultrasound images. The proposed system is able to automatically assign a representative region of interest (ROI) in a liver ultrasound which is subsequently used for diagnosis. This ROI is analyzed using Wavelet Packet Transform (WPT) and a number of statistical features are obtained. A multi-class linear support vector machine (SVM) is then used for classification. The proposed system gives an overall accuracy of ~95% which clearly illustrates the efficacy of the system. © 2011 Springer Science+Business Media, LLC.

Asad M.H.H.B.,COMSATS Institute of Information Technology | Asad M.H.H.B.,Multan Institute of Nuclear Medicine and Radiotherapy MINAR | Sabih D.E.,Multan Institute of Nuclear Medicine and Radiotherapy MINAR | Chaudhory B.A.,Bahauddin Zakariya University | And 5 more authors.
Journal of Animal and Plant Sciences | Year: 2014

Present study was carried out to assess scientifically anti-hemolytic properties of medicinal plants against Pakistani cobra induced hemolysis. Venom from Naja naja and Naja naja karachiensis were found to destabilize human red blood corpuscles membrane (HRBC) however, the effect of later was found somewhat severe. Against Naja naja karachiensis venom twenty six medicinal plants of Pakistan were evaluated but only Cedrus deodara G. Don (P˃0.5) was proved the most effective (72%) in stabilizing HRBC membranes. Althaea officinalis Linn, Calotropis procera (Wild.) R.Br, Citrus limon (L). Burm. f, Enicostemma hyssopifolium (Willd.) Verdoorn, Leucas capitata Desf and Stenolobium stans (L) D. Don were found anti-hemolytic (0.5˃P˃0.1) at various concentration range (20 to 320 μg/mL) in comparison with standard anti-sera (56%). Flowers extract of Calotropis procera (Wild.) R.Br and bulbs of Allium cepa L were found helpful to neutralize snake venom hemolysis at P˂0.1. However, remaining plants extract (p˂0.05) were found to be hemolytic and potentiated the effect of venom instead of having anti-hemolytic potentials. On scientific basis this study emphasizes to rationalize, the use of listed medicinal plants in traditional system of medicine as an anti-hemolytic. Nevertheless, further study is inevitable to identify and isolate bio-active compound(s) from above cited potential medicinal plant(s) extract. © 2014, Pakistan Agricultural Scientists Forum. All Rights reserved.

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