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Kvrak I.,Mugla Stk Kocman UniversityMugla | Kvrak I.,Mugla University | Kvrak S.,Mugla University | Harmandar M.,Mugla University
International Journal of Medicinal Mushrooms | Year: 2016

In this study, the compositions of Calvatia gigantea were first analyzed in order to elucidate its chemical basis for development as a health-enhancing food or medicine. This study investigates the chemical composition (nutritional value; phenolic, sugar and fatty acid content; aroma compounds) and antioxidant properties (radical scavenging activity, reducing power, and inhibition of lipid peroxidation) of C. gigantea. The results showed that C. gigantea contains phenolic compounds and sugars and is rich in polyunsaturated fatty acids (67.93%), proteins (34.37%), and carbohydrates (51.97%). The most abundant compounds were gentisic acid (23.26 μg/g; as a phenolic compound), trehalose (9.78 g/100g; as a sugar), and hexanal (34.71%; as an aroma compound). These findings suggest that C. gigantea might be a promising source of medicine and has the potential to be a health food and food supplementary product. © 2016, Begell House Inc.

Kalemci S.,Mugla Stk Kocman UniversityMugla | Topal Y.,Mugla Stk Kocman UniversityMugla | Celik S.Y.,Mugla Stk Kocman UniversityMugla | Yilmaz N.,Mugla Stk Kocman UniversityMugla | And 4 more authors.
Experimental and Therapeutic Medicine | Year: 2015

The aim of the present study was to assess the protective effect of silibinin against methotrexate (MTX)-induced pulmonary toxicity. Rats were divided into four groups (MTX, MTX + silibinin, silibinin and control. MTX was injected intraperitoneally (i.p) into female Wistar rats (10 mg/kg/day for 3 days), which resulted in significant increases in the serum levels of alanine aminotransferase, aspartate aminotransferase and oxidant enzymes, including nitric oxide and myeloperoxidase. Furthermore, significant reductions were detected in the serum activity levels of the antioxidative enzymes, glutathione peroxidase and superoxide dismutase, when compared with the control group. However, administration of silibinin (100 mg/kg/day for 10 days, i.p.) was shown to ameliorate the MTX-induced pulmonary toxicity, as indicated by the normalization of the oxidative stress parameters. Furthermore, silibinin treatment was demonstrated to reduce the histopathological changes associated with MTX. In conclusion, silibinin exhibited protective effects against MTX-induced pulmonary toxicity, which may be attributed to its antioxidant activity. © 2015, Spandidos Publications. All rights reserved.

Gulsahin N.,Mugla Stk Kocman UniversityMugla | Tarkan A.N.,Mugla Stk Kocman UniversityMugla | Tarkan A.S.,Mugla Stk Kocman UniversityMugla
Turkish Journal of Zoology | Year: 2016

This study was undertaken monthly between September 2011 and October 2012 at 10 stations in Hisaronu, Marmaris, and Fethiye bays of Muğla Province with the aim of examining spatiotemporal patterns of distribution, abundances, and environmental associations of Scyphozoa species. Temperature, salinity, dissolved oxygen, and chlorophyll-a values were measured both on the surface and at a depth of 20 m. Scyphozoa species were sampled by observation and counting from a boat and by diving. Mean temperatures of the sampling stations were between 20.08 and 21.26 °C. Salinity and chlorophyll-a concentrations showed typical Mediterranean features in the bays. Three Scyphozoa species, Aurelia aurita (Linnaeus, 1758), Cotylorhiza tuberculata (Macri, 1778), and Cassiopea andromeda Forskal, 1775, were determined in the sampling sites. C. tuberculata was observed at only one station in Fethiye Bay in August while A. aurita was found at two stations in Fethiye Bay. It showed a bloom in February with abundance of 152 ind./100 m3 at the Fethiye 3 station. Distribution of C. andromeda, which was distributed extensively in the study area, was determined only by scuba diving. This species was observed from April to December with high abundances. Maximum abundances of C. andromeda were 64 ind./100 m2 (August) in Hisaronu Bay, 71 ind./100 m2 (August) in Marmaris Bay, and 64 ind./100 m2 (June) in Fethiye Bay. Significant relationships were detected between environmental variables and Scyphozoa species. C. andromeda was positively and significantly correlated with temperature and negatively with dissolved oxygen, while A. aurita was insignificantly and positively associated with dissolved oxygen and negatively with temperature. © TÜBİTAK.

Kasap B.,Mugla Stk Kocman UniversityMugla | Akbaba G.,Mugla Stk Kocman UniversityMugla | Yeniceri E.N.,Mugla Stk Kocman UniversityMugla | Akn M.N.,Mugla Stk Kocman UniversityMugla | And 4 more authors.
Saudi Medical Journal | Year: 2016

Objectives: To assess current iodine levels and related factors among healthy pregnant women. Methods: In this cross-sectional, hospital-based study, healthy pregnant women (n=135) were scanned for thyroid volume, provided urine samples for urinary iodine concentration and completed a questionnaire including sociodemographic characteristics and dietary habits targeted for iodine consumption at the Department of Obstetrics and Gynecology, School of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey, between August 2014 and February 2015. Sociodemographic data were analyzed by simple descriptive statistics. Results: Median urinary iodine concentration was 222.0 μg/L, indicating adequate iodine intake during pregnancy. According to World Health Organization (WHO) criteria, 28.1% of subjects had iodine deficiency, 34.1% had adequate iodine intake, 34.8% had more than adequate iodine intake, and 3.0% had excessive iodine intake during pregnancy. Education level, higher monthly income, current employment, consuming iodized salt, and adding salt to food during, or after cooking were associated with higher urinary iodine concentration. Conclusion: Iodine status of healthy pregnant women was adequate, although the percentage of women with more than adequate iodine intake was higher than the reported literature. © 2016, Saudi Arabian Armed Forces Hospital. All rights reserved.

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