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Dasdemir A.,HIGH-TECH | Dasdemir A.,Mugla Stk Kocman UniversityMugla | Erturk M.,Balkesir University | Kecebas A.,Mugla Stk Kocman UniversityMugla | Demircan C.,Suleyman Demirel University of Turkey
Energy | Year: 2017

This article reports the effects of air gap on insulation thickness and life cycle costs for different diameter steel pipes. The life cycle cost analysis based on heat degree days is used as a calculation method. Under climatic conditions in Afyonkarahisar, Turkey, using several fuel types and various insulation materials, the annual total costs, energy saving and payback period are evaluated for the insulation of different diameter pipes and also for use of an air gap. The results show that under all conditions, the lowest optimum insulation thickness was found for natural gas and XPS insulation material. Considering all variable parameters in the analysis, optimum insulation thickness, energy cost savings and payback periods for all air gap values varied within the intervals 0.3–25 cm, 20 to 423 $/m-yr and 0.8–2.2 years, respectively. In conclusion, in terms of the effect of air gap on insulation thickness and life cycle costs, for small diameter pipes air gap is effective, whereas for large diameter pipes the insulation thickness plays significant role. © 2017 Elsevier Ltd


Kivrak S.,Mugla Stk Kocman UniversityMugla | Kivrak I.,Mugla Stk Kocman UniversityMugla | Karababa E.,Mugla Stk Kocman UniversityMugla
Food Science and Technology | Year: 2017

This work was conducted to evaluate the quality of 54 honey samples from eighteen different origins from Turkey. Physicochemical properties were examined according to AOAC methods, total phenolic and flavonoid contents by a spectrophotometric method and authenticity of honeys by Combustion Module - Cavity Ring-Down Spectroscopy (CM-CRDS). The microscopic analysis of honey sediment (mellissopalynology) was carried out to identify and count the pollen to provide qualitative indicators to confirm botanical origin. The moisture, electrical conductivity and free acidity of honeys ranged from 15.56 to 18.39%, 0.143 to 2.006 mS.cm-1, 16.05 meq.kg-1 and 34.10 meq.kg-1, respectively. Diastase activity of sideritis honey was found highest. Honeys showed HMF level below 40 mg.kg-1. The highest proline was determined in thyme honey. The results showed that honeys contained eminent amounts of phenolics and flavonoids. δ13C values of honeys were more negative than -23.5‰. The C4% sugar ratios were lower than 7% value. The lowest glucose-fructose content was observed in eucalyptus, cedar and pine honey samples. The results obtained for physicochemical characteristics, total phenolic and flavonoid contents an authenticity analysis of Turkish honeys indicate a good quality level, adequate processing, good maturity and freshness. The discrimination between honey types was achieved by PCA. © 2017, Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA. All rights reserved.


Aim: This study aims to analyze the frequency of childhood traumatic events and its correlation with depression and anxiety cases among midwifery students. Material and Method: The study was based on student self-reports concerning abuse and negligence experiences during their childhood and adolescence, evaluated using the Childhood Trauma Questionnaire (CTQ). The correlation with depression and anxiety was assessed using the Beck Depression Inventory and the Beck Anxiety Inventory. Results: The average scores of emotional neglect and physical neglect were 9.0±3.9 and 7.1±2.5 respectively. The average scores of emotional abuse and sexual abuse were 7.1±2.8 and 5.9±2.2 respectively. The average score of physical abuse was 5.4±1.4. The CTQ total points were significantly associated with depression and anxiety. Discussion: Childhood psychological traumas and emotional abuse may lead to the development of dysfunctional attitudes, causing individuals to be prone to depression and anxiety. Emotional abuse, which is one of the most common traumas in childhood, is a type of trauma that should not be ignored and that should be handled properly in clinical practice. Early traumas may be linked to psychological and behavioural problems in adult life. © 2017, Derman Medical Publishing. All rights reserved.


Emroglu O.,Eskiehir Osmangazi University | Ekmekc F.G.,Hacettepe University | Aksu S.,Eskiehir Osmangazi University | Baskurt S.,Eskiehir Osmangazi University | And 2 more authors.
Acta Ichthyologica et Piscatoria | Year: 2016

The aim of this study was to report non-native tropical ornamental freshwater fi sh species from the Pınarbaşı Stream connected with hot-water sources in the İnönü Province (Eskişehir, Turkey). The morphological characters and meristic counts indicated that the examined specimens were: Pterygoplichthys disjunctivus (Weber, 1991), Pterygoplichthys pardalis (Castelnau, 1855), and their hybrids. We also present the evidence of their reproduction and establishment. Successful invasion of these species was evident, as their young-of-the-year and juvenile individuals were caught during the samplings from the same water course. Finally, we discuss the management implications of these species. © 2016, Scientific Society of Szczecin. All rights reserved.


Karaman N.,University of Gaziantep | Scak Y.,Mugla Stk Kocman UniversityMugla | Taskn-Tok T.,University of Gaziantep | Ozturk M.,Mugla Stk Kocman UniversityMugla | And 4 more authors.
European Journal of Medicinal Chemistry | Year: 2016

Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidine-1-carboxylate and 2,6-diphenylpiperidin-4-one. The synthesized compounds (1−19) were screened for their antioxidant, anticholinesterase and anticancer activities. The antioxidant capacity of the compounds was evaluated by using four complementary tests. The results showed that compound 7 and 17 have the higher lipid peroxidation inhibitory activity than the other compounds. In DPPH˙ scavenging assay, compounds 5, 6, 10, 14, 17 demonstrated better activity than that of standard BHT, while in ABTS+˙ scavenging assay compound 6 and 17 exhibited better activity among the other compounds. The CUPRAC assay disclosed that compound 2 displayed better activity than α-tocopherol. The anticholinesterase activity was performed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Compound 11 (IC50: 35.30 ± 1.11 μM) inhibited BChE better than galantamine (IC50: 46.03 ± 0.14 μM). We conclude that the compound 11 can be considered as a candidate for BChE inhibitor. Moreover docking method was applied to elucidate the AChE and BChE inhibitory mechanism of the compound 11. Molecular docking analysis revealed that compound 11 bound to BChE enzyme more efficiently when compared to the AChE due to its orientations and different types of interactions. In addition, the non-cytotoxic properties of the compounds brought them into prominence, although they did not show significant anticancer properties. © 2016 Elsevier Masson SAS


Kasap B.,Mugla Stk Kocman UniversityMugla | Akbaba G.,Mugla Stk Kocman UniversityMugla | Yeniceri E.N.,Mugla Stk Kocman UniversityMugla | Akn M.N.,Mugla Stk Kocman UniversityMugla | And 4 more authors.
Saudi Medical Journal | Year: 2016

Objectives: To assess current iodine levels and related factors among healthy pregnant women. Methods: In this cross-sectional, hospital-based study, healthy pregnant women (n=135) were scanned for thyroid volume, provided urine samples for urinary iodine concentration and completed a questionnaire including sociodemographic characteristics and dietary habits targeted for iodine consumption at the Department of Obstetrics and Gynecology, School of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey, between August 2014 and February 2015. Sociodemographic data were analyzed by simple descriptive statistics. Results: Median urinary iodine concentration was 222.0 μg/L, indicating adequate iodine intake during pregnancy. According to World Health Organization (WHO) criteria, 28.1% of subjects had iodine deficiency, 34.1% had adequate iodine intake, 34.8% had more than adequate iodine intake, and 3.0% had excessive iodine intake during pregnancy. Education level, higher monthly income, current employment, consuming iodized salt, and adding salt to food during, or after cooking were associated with higher urinary iodine concentration. Conclusion: Iodine status of healthy pregnant women was adequate, although the percentage of women with more than adequate iodine intake was higher than the reported literature. © 2016, Saudi Arabian Armed Forces Hospital. All rights reserved.


Kvrak I.,Mugla Stk Kocman UniversityMugla | Kvrak I.,Muǧla University | Kvrak S.,Muǧla University | Harmandar M.,Muǧla University
International Journal of Medicinal Mushrooms | Year: 2016

In this study, the compositions of Calvatia gigantea were first analyzed in order to elucidate its chemical basis for development as a health-enhancing food or medicine. This study investigates the chemical composition (nutritional value; phenolic, sugar and fatty acid content; aroma compounds) and antioxidant properties (radical scavenging activity, reducing power, and inhibition of lipid peroxidation) of C. gigantea. The results showed that C. gigantea contains phenolic compounds and sugars and is rich in polyunsaturated fatty acids (67.93%), proteins (34.37%), and carbohydrates (51.97%). The most abundant compounds were gentisic acid (23.26 μg/g; as a phenolic compound), trehalose (9.78 g/100g; as a sugar), and hexanal (34.71%; as an aroma compound). These findings suggest that C. gigantea might be a promising source of medicine and has the potential to be a health food and food supplementary product. © 2016, Begell House Inc.


Gulsahin N.,Mugla Stk Kocman UniversityMugla | Tarkan A.N.,Mugla Stk Kocman UniversityMugla | Tarkan A.S.,Mugla Stk Kocman UniversityMugla
Turkish Journal of Zoology | Year: 2016

This study was undertaken monthly between September 2011 and October 2012 at 10 stations in Hisaronu, Marmaris, and Fethiye bays of Muğla Province with the aim of examining spatiotemporal patterns of distribution, abundances, and environmental associations of Scyphozoa species. Temperature, salinity, dissolved oxygen, and chlorophyll-a values were measured both on the surface and at a depth of 20 m. Scyphozoa species were sampled by observation and counting from a boat and by diving. Mean temperatures of the sampling stations were between 20.08 and 21.26 °C. Salinity and chlorophyll-a concentrations showed typical Mediterranean features in the bays. Three Scyphozoa species, Aurelia aurita (Linnaeus, 1758), Cotylorhiza tuberculata (Macri, 1778), and Cassiopea andromeda Forskal, 1775, were determined in the sampling sites. C. tuberculata was observed at only one station in Fethiye Bay in August while A. aurita was found at two stations in Fethiye Bay. It showed a bloom in February with abundance of 152 ind./100 m3 at the Fethiye 3 station. Distribution of C. andromeda, which was distributed extensively in the study area, was determined only by scuba diving. This species was observed from April to December with high abundances. Maximum abundances of C. andromeda were 64 ind./100 m2 (August) in Hisaronu Bay, 71 ind./100 m2 (August) in Marmaris Bay, and 64 ind./100 m2 (June) in Fethiye Bay. Significant relationships were detected between environmental variables and Scyphozoa species. C. andromeda was positively and significantly correlated with temperature and negatively with dissolved oxygen, while A. aurita was insignificantly and positively associated with dissolved oxygen and negatively with temperature. © TÜBİTAK.


Derin S.,Mugla Stk Kocman UniversityMugla | Koseoglu S.,Mugla Stk Kocman UniversityMugla | Sahin C.,Mugla Stk Kocman UniversityMugla | Sahan M.,Mugla Stk Kocman UniversityMugla
International Forum of Allergy and Rhinology | Year: 2016

Background: Vitamin B12 plays a major role in the maintenance of central and peripheral nervous systems. Vitamin B12 deficiency may affect the spinal cord, brain, optic nerve, and peripheral nerve functions; however, the effect of vitamin B12 deficiency on olfactory function has not been studied, so our study aimed to investigate that. Methods: Thirty-nine patients with low vitamin B12 levels and 34 controls were included in the study. All participants had detailed otorhinolaryngological examinations and laboratory tests. The Sniffin’ Stick test was used for analysis of olfactory function. The 2 groups were compared for smell test results. Correlations of smell test results with demographic and laboratory data were investigated in the vitamin B12–deficient group. Results: The threshold discrimination identification scores were (mean ± standard deviation) 28.04 ± 5.58 and 35.10 ± 2.84 in the vitamin B12–deficient and control groups, respectively (p < 0.001). In the vitamin B12–deficient group, hyposmia and anosmia were evident in 56.4% and 5.1% of the patients, respectively, but no subjects in the control group had olfactory dysfunction (p < 0.001). Correlation analysis showed that age and odor identification score showed a negative correlation (p < 0.001); however, there was a positive correlation between threshold, discrimination and identification (TDI) score and vitamin B12 levels. Conclusion: In this study, we showed for the first time that olfactory dysfunction may be present in patients with vitamin B12 deficiency. Apart from a negative correlation of age with odor identification score, none of the other parameters studied showed correlations with olfactory dysfunction. © 2016 ARS-AAOA, LLC


Kalemci S.,Mugla Stk Kocman UniversityMugla | Topal Y.,Mugla Stk Kocman UniversityMugla | Celik S.Y.,Mugla Stk Kocman UniversityMugla | Yilmaz N.,Mugla Stk Kocman UniversityMugla | And 4 more authors.
Experimental and Therapeutic Medicine | Year: 2015

The aim of the present study was to assess the protective effect of silibinin against methotrexate (MTX)-induced pulmonary toxicity. Rats were divided into four groups (MTX, MTX + silibinin, silibinin and control. MTX was injected intraperitoneally (i.p) into female Wistar rats (10 mg/kg/day for 3 days), which resulted in significant increases in the serum levels of alanine aminotransferase, aspartate aminotransferase and oxidant enzymes, including nitric oxide and myeloperoxidase. Furthermore, significant reductions were detected in the serum activity levels of the antioxidative enzymes, glutathione peroxidase and superoxide dismutase, when compared with the control group. However, administration of silibinin (100 mg/kg/day for 10 days, i.p.) was shown to ameliorate the MTX-induced pulmonary toxicity, as indicated by the normalization of the oxidative stress parameters. Furthermore, silibinin treatment was demonstrated to reduce the histopathological changes associated with MTX. In conclusion, silibinin exhibited protective effects against MTX-induced pulmonary toxicity, which may be attributed to its antioxidant activity. © 2015, Spandidos Publications. All rights reserved.

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