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Bors I.,MTA KE Mycotoxins in the Food Chain Research Group | Szabo-Fodor J.,MTA KE Mycotoxins in the Food Chain Research Group | Kovacs M.,MTA KE Mycotoxins in the Food Chain Research Group | Kovacs M.,University of Kaposvar
Poljoprivreda | Year: 2015

Maize (Zea mays L.) is often contaminated with Fusarium verticillioides. This harmful fungus produces fumonisins as secondary metabolites. These fumonisins can appear both free and hidden form in planta. The hidden form is usually bound covalently to cereal starch. From the hidden fumonisins, during enzymatic degradation, glycosides are formed, and the fumonisin is further decomposed during a de-esterification step. In this short communication some preliminary DFT calculated structural results which could be useful in the future to help to understand the van der Waals force controlled molecular interactions between these kinds of mycotoxin molecules and enzymes are demonstrated. © 2015, Faculty of Agriculture in Osijek. All rights reserved. Source

Posa R.,University of Kaposvar | Magyar T.,Hungarian Academy of Sciences | Stoev S.D.,Trakia University | Glavits R.,Autopsy kkt | And 3 more authors.
Veterinary Pathology | Year: 2013

Mycoplasma hyopneumoniae has a primary role in the porcine respiratory disease complex (PRDC). The objective of this study was to determine whether fumonisin mycotoxins influence the character and/or the severity of pathological processes induced in the lungs of pigs by Mycoplasma hyopneumoniae. Four groups of pigs (n = 7/group) were used, one fed 20 ppm fumonisin B1 (FB1) from 16 days of age (group F), one only infected with M. hyopneumoniae on study day 30 (group M), and a group fed FB1 and infected with M. hyopneumoniae (group MF), along with an untreated control group (group C). Computed tomography (CT) scans of infected pigs (M and MF) on study day 44 demonstrated lesions extending to the cranial and middle or in the cranial third of the caudal lobe of the lungs. The CT images obtained on study day 58 showed similar but milder lesions in 5 animals from group M, whereas lungs from 2 pigs in group MF appeared progressively worse. The evolution of average pulmonary density calculated from combined pixel frequency values, as measured by quantitative CT, was significantly influenced by the treatment and the age of the animals. The most characteristic histopathologic lesion in FB1-treated pigs was pulmonary edema, whereas the pathomorphological changes in Mycoplasma-infected pigs were consistent with catarrhal bronchointerstitial pneumonia. FB1 aggravated the progression of infection, as demonstrated by severe illness requiring euthanasia observed in 1 pig and evidence of progressive pathology in 2 pigs (group MF) between study days 44 and 58. © The Author(s) 2013. Source

Kovacs M.,University of Kaposvar | Kovacs M.,MTA KE Mycotoxins in the Food Chain Research Group | Tornyos G.,University of Kaposvar | Matics Z.,MTA KE Mycotoxins in the Food Chain Research Group | And 7 more authors.
Animal Reproduction Science | Year: 2013

T-2 toxin (T-2) was administered to adult Pannon White (n=10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2. mg/animal/day), and secondly mixed into the feed (0.33 and 0.66. mg/kg feed). In the first experiment 0.1. mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin-releasing hormone (GnRH) induced testosterone synthesis, slight centrolobular infiltration in the liver and a slight hyperplasia of the Leydig cells. In addition to the temporary feed refusal effect, 0.2. mg T-2 caused a temporary decrease in plasma albumin and urea concentrations, lesser glutathione peroxidase (GPx) activity in the seminal plasma, a greater (by 320%) ratio of spermatozoa with cytoplasmic droplets, slower increase in the GnRH-induced testosterone synthesis, centrolobular infiltration in the liver, slightly hyperaemic testes and increased proliferative activity of the Leydig cells. The two smaller doses applied in feed (0.33 and 0.66. mg/kg) did not cause any significant adverse effect, and no feed refusal was observed. According to these results the No Observed Adverse Effect Level (NOAEL) of T-2 for adult rabbit males was found to be <0.1. mg/animal/day (<0.02. mg/kg. b.w./day). © 2013 Elsevier B.V. Source

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