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Holyoke, MA, United States

Kitko L.A.,Pennsylvania State University | Hupcey J.E.,Pennsylvania State University | Gilchrist J.H.,Mt Holyoke College | Boehmer J.P.,Heart and Vascular Institute
Heart and Lung: Journal of Acute and Critical Care | Year: 2013

Objectives: This qualitative study describes the experiences of spousal caregivers of a patient with end-stage heart failure (HF) from pre-LVAD to post-LVAD-DT implantation. Background: LVAD-DTs are implanted as permanent devices for end-stage HF patients with the goal of improving the length and quality of life. LVADs create new demands for both patients and caregivers. Methods: In-depth, semi-structured interviews of 10 spousal caregivers were thematically analyzed. Results: Throughout the process of caregiving, pre-implant through post-implant, all caregivers discussed their ability to adapt within the role as a caregiver. Adaptation as a caregiver occurred through three distinct time frames following the progression of the patient's HF and subsequent LVAD implantation: caring for a spouse with HF, decision for LVAD implantation made, and caring for a spouse with the LVAD-DT. Conclusions: Caregivers were able to adapt and develop effective strategies to incorporate the demands of caring for a spouse with an LVAD-DT, but the role remained challenging. The findings underscore the need for continued research that may be translated into effective interventions to support patient and caregivers as they live through this end-of-life trajectory. © 2013 Elsevier Inc. Source


Klein B.R.,Western Connecticut Health Network | Brown E.N.,Mt Holyoke College | Casden R.S.,Western Connecticut Health Network
Journal of Cataract and Refractive Surgery | Year: 2016

Purpose To evaluate spectral-domain optical coherence tomography (SD-OCT) as a strategy for identifying occult macular disease preoperatively in patients scheduled for cataract surgery with implantation of an advanced-technology intraocular lens (IOL). Setting Private practice, Danbury, Connecticut, USA. Design Retrospective consecutive case series. Methods Macular SD-OCT scans were performed on all patients scheduled for cataract surgery and Restor multifocal or toric IOL implantation over a 6-month period. All scans were reviewed for abnormalities of the retina, retinal pigment epithelium, or vitreomacular interface. For subgroup analysis, the following health information was collected: age, sex, smoking history, hypertension, heart disease, hyperlipidemia or hypercholesterolemia, and diabetes. Results Two hundred sixty-five consecutive scans from 149 patients were obtained. Macular pathology was found in 35 eyes (13.2%). The most common condition was age-related macular degeneration in 15 eyes (5.66%) followed by idiopathic epiretinal membrane in 11 eyes (4.15%). Ischemic atrophy from previously undiagnosed retinal vascular pathology was found in 5 eyes (1.89%) and edema in 3 eyes (1.13%). A subgroup analysis found a higher incidence of macular pathology in patients with a history of heart disease (30.6%, P <.001) or smoking (20.2%, P <.05), and in men (23.9%, P <.01). Media opacities precluded interpretation of 17 scans (6.42%). Conclusion Preoperative macular SD-OCT scanning was effective in identifying patients at risk for compromised visual outcomes after advanced-technology IOL surgery. Financial Disclosure None of the authors has a financial or proprietary interest in any material or method mentioned. © 2016 ASCRS and ESCRS. Source


Evans K.A.,Curtin University Australia | Dyar M.D.,Mt Holyoke College | Reddy S.M.,Curtin University Australia | Lanzirotti A.,University of Chicago | And 2 more authors.
American Mineralogist | Year: 2014

Microscale analysis of ferrous:ferric iron ratios in silicate minerals has the potential to constrain geological processes but has proved challenging because textural information and spatial resolution are limited with bulk techniques, and in situ methods have limited spatial resolution. Synchrotron methods, such as XANES, have been hampered by the sensitivity of spectra to crystal orientation and matrix effects. In an attempt to break this nexus, biotites from Tanzania were characterized with a combination of optical microscopy, electron microprobe, Mössbauer analysis, electron backscatter diffraction (EBSD) and X-ray absorption near edge structure (XANES) spectroscopy. Pre-edge and edge characteristics of the FeKα absorption feature were compared to orientation information derived by EBSD and ferric iron content derived from Mössbauer analysis. Statistically significant correlations between measured spectral features and optic/crystallographic orientation were observed for individual samples. However, orientation corrections derived from these correlations did not reduce the uncertainty in Fe3+/Fetot. The observations are consistent with matrix- and ordering-dependency of the XANES features, and further work is necessary if a general formulation for orientation corrections is to be devised. © 2014 by Walter de Gruyter GmbH & Co. 2014. Source


Revealed I.,University of Minnesota | Yuwono V.M.,University of Minnesota | Burrows N.D.,University of Minnesota | Soltis J.A.,Mt Holyoke College | Lee Penn R.,University of Minnesota
Journal of the American Chemical Society | Year: 2010

(Figure Presented) Oriented aggregation is a special case of aggregation in which nanocrystals self-assemble and form new secondary single crystals. This process has been suggested to proceed via an intermediate state known as the mesocrystal, in which the nanocrystals have parallel crystallographic alignment but are spatially separated. We present the first direct observations of mesocrystals with size and shape similar to product oriented aggregates by employing cryo-TEM to directly image the particles in aqueous suspension. The cryo-TEM images reveal that mesocrystals not only form but also transform to the final single crystal product while in the dispersed state. Further, high-resolution cryo-TEM images demonstrate that the mesocrystals are composed of spatially separated and crystallographically aligned nanocrystals. Copyright © 2010 American Chemical Society. Source


Biermann J.,Mt Holyoke College | Van Tuyl A.,Lakehead University
Electronic Journal of Combinatorics | Year: 2013

Given any finite simplicial complex Δ, we show how to construct from a colouring X of Δ a new simplicial complex ΔX that is balanced and vertex decomposable. In addition, the h-vector of ΔX is precisely the f-vector of Δ. Our construction generalizes the "whiskering" construction of Villarreal, and Cook and Nagel. We also reverse this construction to prove a special case of a conjecture of Cook and Nagel, and Constantinescu and Varbaro on the h-vectors of flag complexes. Source

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