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Durgadas S.,Jawaharlal Nehru Technological University | Durgadas S.,MSN Pharmachem Pvt. Ltd | Mukkanti K.,Jawaharlal Nehru Technological University | Pal S.,MNR Degree and PG College
MolBank | Year: 2013

The title compound, N-{2-[3-(3-formyl-2-oxoquinolin-1(2H)-yl)prop-1- ynyl]phenyl}acetamide was synthesized in high yield by Sonogashira cross coupling of 2-oxo-1-(prop-2-ynyl)-1,2-dihydroquinoline-3-carbaldehyde with N-(2-iodophenyl)acetamide. The structure of the compound was fully characterized by IR, 1H-NMR, 13C-NMR, Mass spectral analysis and elemental analysis. © 2013 by the authors; licensee MDPI, Basel, Switzerland. Source


Durgadas S.,University of Hyderabad | Durgadas S.,MSN Pharmachem Pvt. Ltd | Chatare V.K.,MNR Degree and PG College | Mukkanti K.,University of Hyderabad | Pal S.,MNR Degree and PG College
Applied Organometallic Chemistry | Year: 2010

Synthesis of a series of compounds structurally related to the anti-inflammatory agent nimesulide has been accomplished via Pd-catalyzed C-C bond forming reactions. Thus 4-iodo derivative, prepared from nimesulide, participated in Sonogashira (copper-free), Heck and Suzuki coupling reactions to afford the corresponding alkynyl alkenyl and aryl substituted products. Some of the compounds synthesized were tested for anti-inflammatory activities in vivo. Copyright © 2010 John Wiley & Sons, Ltd. Source


Praveena K.S.S.,MNR Degree and PG College | Durgadas S.,MSN Pharmachem Pvt. Ltd | Suresh Babu N.,Jawaharlal Nehru Technological University | Akkenapally S.,Indian Institute of Chemical Technology | And 5 more authors.
Bioorganic Chemistry | Year: 2014

The 2,2,4-trimethyl-1,2-dihydroquinolinyl substituted 1,2,3-triazole derivatives were designed as potential inhibitors of PDE4B. These compounds were synthesized via a multi-step sequence consisting of copper-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step in aqueous media. The required alkynes were prepared from nimesulide via N-propargylation and then nitro group reduction followed by a CAN mediated modified Skraup reaction of the resulting amine. All the synthesized compounds showed PDE4B inhibitory properties in vitro at 30 μM with two compounds showing >50% inhibition that were supported by the in silico docking results of these compounds at the active site of PDE4B. Three of these PDE4 inhibitors showed promising cytotoxic properties against A549 human lung cancer cells in vitro with IC50 ∼8-9 μM. © 2013 Elsevier Inc. All rights reserved. Source


Durgadas S.,Jawaharlal Nehru Technological University Anantapur | Durgadas S.,MSN Pharmachem Pvt. Ltd | Chatare V.K.,MNR Degree and PG College | Mukkanti K.,Jawaharlal Nehru Technological University Anantapur | Pal S.,MNR Degree and PG College
Letters in Organic Chemistry | Year: 2010

Ceric ammonium nitrate (CAN) catalyzed the one-pot synthesis of 2,2,4-trirnethyl-1,2-dihydroquinoline derivatives from substituted anilines and acetone via a modified Skraup reaction. The methodology was used to synthesize a novel dihydroquinoline-based compound derived from an anti-inflammatory agent nimesulide. © 2010 Bentham Science Publishers Ltd. Source

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