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Dubey A.P.,Maulana Azad Medical College Hospital | Agarkhedkar S.,Dr DY Patil Medical College & Hospital | Chhatwal J.,Christian Medical College Hospital | Narayan A.,MS Ramaiah Medical College Hospitals | And 4 more authors.
Human Vaccines and Immunotherapeutics | Year: 2016

Dengue is a mosquito-borne viral disease that is endemic in India. We evaluated the immunogenicity and safety of recombinant, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in Indian adults. In this observer-blind, randomized, placebo-controlled, Phase II study, adults aged 18–45 years were randomized 2:1 to receive CYD-TDV or placebo at 0, 6 and 12 months in sub-cutaneous administration. Immunogenicity was assessed using a 50% plaque reduction neutralization test (PRNT50) at baseline and 28 days after each study injection. 189 participants were enrolled (CYD-TDV [n = 128]; placebo, [n = 61]). At baseline, seropositivity rates for dengue serotypes 1, 2, 3 and 4 ranged from 77.0% to 86.9%. Seropositivity rates for each serotype increased after each CYD-TDV injection with a more pronounced increase after the first injection. In the CYD-TDV group, geometric mean titres (GMTs) were 2.38 to 6.11-fold higher after the third injection compared with baseline but remained similar to baseline in the placebo group. In the CYD-TDV group, the GMTs were 1.66 to 4.95-fold higher and 9.23 to 24.6-fold higher after the third injection compared with baseline in those who were dengue seropositive and dengue seronegative, respectively. Pain was the most commonly reported solicited injection site reaction after the first injection in both the CYD-TDV (6.3%) and placebo groups (4.9%), but occurred less frequently after subsequent injections. No serious adverse events were vaccine-related, no immediate unsolicited adverse events, and no virologically-confirmed cases of dengue, were reported during the study. The immunogenicity and safety of CYD-TDV was satisfactory in both dengue seropositive and seronegative Indian adults. © 2016, © Anand Prakash Dubey, Sharad Agarkhedkar, Jugesh Chhatwal, Arun Narayan, Satyabrata Ganguly, T Anh Wartel, Alain Bouckenooghe, and Josemund Menezes. Source

Aishwarya K.C.,KVG Medical College and Hospital | Srinath M.G.,MS Ramaiah Medical College Hospitals | Desai S.C.,MS Ramaiah Medical College Hospitals | Ashok Kumar A.,MS Ramaiah Medical College Hospitals | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Objective: To know the value of preoperative Dopplerultrasonography vascular mapping of upper limb for hemodialysis access placement. Materials and Methods: Prospective ultrasonographic assess-ment of upper extremity vessels was performed in 60 patients prior to hemodialysis access placement and potential access sites were selected (based on the standard criteria). The findings were correlated with the operative findings. Discrepancies found between ultrasonographic and operative findings were analysed. Results: All the 60 patients who underwent vascular mapping had vascular access placed. 80% of them had native arteriovenous fistulae (AVF) placed. In 95% of patients, at the selected sites, the vascular parameters as determined by ultrasonography matched with the operative findings. In 5%of patients there were discrepancies between the ultrasonography findings and operative findings. There was no negative surgical exploration. There was strong correlation between the diameters measured by ultrasonography and surgery. Conclusion: Preoperative ultrasonography vascular mapping prior to hemodialysis access placement has facilitated definite selection of potential sites in difficult patient population in whom evaluation by physical examination was inconclusive. It also helped in maximizing the native AVFs and decreasing the negative surgical exploration rates. © 2014 Journal of Clinical and Diagnostic Research. All Rights Reserved. Source

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