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Tauro D.P.,Center for Cranio Maxillofacial Plastic and Reconstructive Surgery | Kumar K.K.,Sibar Institute of Dental science | Shibani S.,Mr Ambedkar Dental College
Journal of Oral Biology and Craniofacial Research | Year: 2012

Kimura's disease (KD) is a rare chronic inflammatory disorder that involves the subcutaneous tissues and occurs predominantly in the head and neck region, frequently associated with regional lymphadenopathy or salivary gland involvement. Although, not an uncommon condition in the Asian countries, it is quite rare among the occidental civilization and in the western countries is more commonly diagnosed among Asian migrants. Kimura's disease is sometimes confused with angiolymphoid hyperplasia with eosinophilia, which occurs in the superficial skin of the head and neck region. The classical features of angiolymphoid hyperplasia with eosinophilia are characterized by a triad of painless subcutaneous masses in the head and neck region, blood and tissue eosinophilia, and markedly elevated immunoglobulin E (IgE) levels. Here, we report a case of a 33-year-old Indian male with KD who presented with unilateral nodular swelling in the right parotid region. The diagnosis was based on characteristic histopathologic findings in conjunction with peripheral eosinophilia and elevated serum IgE levels. © 2012 Craniofacial Research Foundation.

Kumar V.,MS Ramaiah Dental College | Krishna Murthy A.,Mr Ambedkar Dental College | Suresh K.P.,Indian National Institute of Animal Nutrition and Physiology
Asian Pacific Journal of Cancer Prevention | Year: 2011

Background: Polymorphic variations in GSTM1 and GSTT1 have been implicated as risk factors for various cancers. A number of studies conducted to assess their association with susceptibility to laryngeal carcinomas have yielded inconsistent and inconclusive results. In the present study, the possible association of laryngeal cancer risk with GSTM1 and GSTT1 null genotypes was explored by a meta analysis. Method: A meta-analysis was carried out on case-control studies collected from the literature. The pooled odds ratio (OR) and presence of publication bias in those studies were evaluated. Results: A total of 20 studies concerning laryngeal cancer were identified. The results showed that the pooled OR was 1.22 (95% CI 1.03-1.43) for the GSTM1 polymorphism while for GSTT1 polymorphism, the pooled OR was 1.23 (95% CI 0.96-1.58). No evidence of publication bias was detected among the included studies. Conclusion: The results suggest that the GSTM1 deficiency significantly increases susceptibility to laryngeal cancer whereas GSTT1 null genotype might not be a risk factor.

Murthy A.K.,Mr Ambedkar Dental College | Kumar V.,Geetam Dental College | Suresh K.P.,Animal Disease Monitoring and Surveillance
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: Studies of associations between genetic polymorphism of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) with risk of nasopharyngeal cancer (NPC) have generated conflicting results. Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on the risk of developing NPC. Materials and Methods: A literature search in two electronic databases namely PubMed and EMBASE up to December 2012 was conducted and eligible papers were finally selected based on the inclusion and exclusion criteria. The pooled odds ratio (OR) and presence of heterogeneity and publication bias in those studies were evaluated. Results: A total of 9 studies concerning nasopharyngeal cancer were evaluated. Analyses of all relevant studies showed increased NPC risk to be significantly associated with the null genotypes of GSTMI (OR=1.43, 95%CI 1.24-1.66) and GSTT1 (OR=1.28, 95%CI=1.09-1.51). In addition, evidence of publication bias was detected among the studies on GSTM1 polymorphism. Conclusions: This meta-analysis demonstrated the GSTM1 G STM1 and GSTT1 null genotypes are associated with an increased risk of NPC.

Jain V.K.,Mr Ambedkar Dental College | Uma K.,Kle Dental College | Soundarya N.,Mr Ambedkar Dental College | Sangeetha R.,Mr Ambedkar Dental College | Smitha T.,VS Dental College
Journal of Oral and Maxillofacial Pathology | Year: 2012

Aims: To compare the area and number of AgNORs (silver stained nucleolar organizer regions) by morphometry between follicular and plexiform variants of ameloblastoma in order to analyze their cell proliferation rates. Materials and Methods: This retrospective study was carried out on 30 cases each of follicular and plexiform ameloblastoma. The sections were obtained and stained with silver staining technique to identify the nucleolar organizer regions. AgNORs were quantified using two parameters; manual tag for the number of AgNORs and area measurement using the image analyzer software, Image-Pro-Express. Results: Morphometric area measurements of AgNOR were significantly higher for Plexiform ameloblastoma (0.831m 2) than follicular ameloblastoma (0.528m 2). Enumeration of the number of AgNORs showed a significantly higher number of AgNOR for follicular ameloblastoma (1.71) than plexiform ameloblastoma (1.43). Among the groups studied, follicular ameloblastoma was more aggressive than plexiform ameloblastoma, as it showed smaller AgNOR area and higher AgNOR number. Conclusion: The combination of counting the number and measuring the area of AgNOR dots showed a significant overall difference between AgNOR profiles of follicular and plexiform variants of ameloblastoma.

Ananth H.,Mr Ambedkar Dental College | Kundapur V.,Mr Ambedkar Dental College | Mohammed H.S.,Mr Ambedkar Dental College | Anand M.,Mr Ambedkar Dental College | And 2 more authors.
International Journal of Biomedical Science | Year: 2015

Implants have been gaining popularity amongst the patients and frequently are being considered as a first treatment option. Modern dentistry is beginning to understand, realize, and utilize the benefits of biotechnology in health care. Study of material sciences along with the biomechanical sciences provides optimization of design and material concepts for surgical implants. Biocompatibility is property of implant material to show favorable response in given biological environment. In attempt to replace a missing tooth many biomaterials have been evolved as implants for many years in an effort to create an optimal interaction between the body and the implanted material. With all the advancements and developments in the science and technology, the materials available for dental implants also improved. The choice of material for a particular implant application will generally be a compromise to meet many different required properties. There is, however, one aspect that is always of prime importance that how the tissue at the implant site responds to the biochemical disturbance that a foreign material presents. © 2015 Hariprasad Ananth et al.

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