Mount Carmel College Autonomous

Bangalore, India

Mount Carmel College Autonomous

Bangalore, India
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Vinayak A.,Mount Carmel Center for Scientific Research and Advanced Learning | Sudha M.,Mount Carmel College Autonomous | Lalita K.S.,Chemistry Discipline
Dhaka University Journal of Pharmaceutical Sciences | Year: 2017

A linear strategy was adopted in synthesizing the novel amine derivatives 7(a-h) of 5-[5-(chloromethyl)-1, 3, 4-oxadiazol-2-yl]-2-(4-fluorophenyl)-pyridine (6) and screened these compounds for in vitro anticancer activity against three human cancer cell lines (HeLa,Caco-2 and HepG2). The synthesised novel compounds were characterized by1H NMR, MS and13C NMR spectroscopic evidences. Microwave irradiation of compound (5) in presence of chloroacetyl chloride and phosphoryl oxychloride yielded the dehydrated cyclized key intermediate 5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-2-(4-fluorophenyl)-pyridine which upon treatment with various primary or secondary amines (a-h) resulted into the corresponding amine derivatives. The IC50 values of the final compounds were compared with that of 5-fluorouracil (5-FU) taken as the standard. Compounds 7a and 7d were found to be highly cytotoxic against HepG2 cell lines with IC50 values of 2.6 µM (IC50 = 34.0 ± 0.5 µM) and 5.8 µM (IC50 = 112 ± 1.4 µM) respectively. The compound (7f) alone was found to have high cytotoxicity against Caco-2 cell lines with IC50 value of 2.3 µM (IC50 = 87 ± 2.6 µM). © 2017, University of Dhaka. All rights reserved.

Pal P.,CSIR - Central Electrochemical Research Institute | Pal P.,Mount Carmel College Autonomous | Shaw A.K.,CSIR - Central Electrochemical Research Institute
RSC Advances | Year: 2017

Cyclic enol ether frameworks, especially stereochemically pure furanoid and pyranoid glycals are well known highly functionalized chiral building blocks. Furanoid glycals have been shown to possess great potential, as they have been used as key intermediates for the synthesis of structurally diverse molecules including natural products with various biological activities since their discovery in 1963 by Ness and Fletcher. In this review on furanoid glycals, efforts are made to exhaustively compile the work centered on synthesis and utility of furanoid glycals since the inception to date. This review aims to highlight the importance of furanoid glycals and the strategies developed over the years for their synthesis. Attention has also been focused on the use of these furanoid glycals toward the synthesis of natural and unnatural products including C-and N-nucleosides of biological importance. Apart from that, efforts are also devoted to cover the significant applications of these furanoid glycals for stereoselective synthesis of various cyclic and acyclic key intermediates of significant interest. © 2017 The Royal Society of Chemistry.

Vinayak A.,Mount Carmel Center for Scientific Research and Advanced Learning | Sudha M.,Mount Carmel College Autonomous | Kumar R.P.,Mount Carmel Center for Scientific Research and Advanced Learning
International Journal of Drug Development and Research | Year: 2014

In this linear synthesis, novel different 2-chloro N-aryl substitutedacetamide derivatives of 5-[2-(4-methoxyphenyl) pyridin-3-yl]-1, 3, 4-oxadiazole-2-thiol have been synthesized and screened for their cytotoxicity on PANC-1, HepG2 and MCF7 cell lines and obtained the IC50and CC50values.All the synthesized compounds were characterized by LCMS, IR,1H and13C (proton and Carbon 13) spectroscopies and elemental analysis. These compounds were evaluated for invitro anticancer activity on three different human leukemic cell lines, namely PANC-1, HepG2 and MCF7.In total five compounds were synthesized and studied for their MTT assay. Among five synthesized novel compounds, the compound N-[5-(4-Methoxy-phenyl)-pyridin-2-yl]-2-{5-[2-(4-methoxy-phenyl)-pyridin-3-yl][1,3,4]oxadiazol-2-ylsulfanyl}-acetamide6e is highly cytotoxic on PANC-1 and HepG2 cell lines having IC50of 4.6μM and 2.2μM respectively whereas the compound 6c is moderately cytotoxic on MCF7 having IC50 15.5μM respectively. Rest all the compounds showed less cytotoxicity on all the three cell lines as compared with the standard 5-FU. © 2014 Adimule Vinayak et al, publisher and licensee IYPF.

Balakrishnan K.P.,Research and Development Center | Narayanaswamy N.,Research and Development Center | Mathews S.,Mount Carmel College Autonomous | Gurung K.,Mount Carmel College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2011

Dandruff caused by Malassezia spp is controlled by antifungal agents. In the present study four medicinal plants- Terminalia bellerica, Terminalia chebula, Emblica officinalis and Lantana camara- were selected to check their antifungal activity. Their efficacy was tested using different concentrations of extracts in various solvents. The antifungal activity of the plant extracts was determined by well diffusion method. Among the four plants screened, Terminalia bellerica and Terminalia chebula exhibited good antifungal action against the test organism. Emblica officinalis and Lantana camara did not show significant antidandruff activity. Aqueous and ethanolic extract of a combination of Terminalia bellerica with Lantana camara, and Terminalia chebula with Lantana camara were tested for their synergistic antidandruff activity. Results of the synergistic studies indicated that synergy exists between ethanolic extracts of Terminalia chebula and Lantana camara. From the study, it was found that Terminalia bellerica and Terminalia chebula act as the good sources of antidandruff agents.

Balakrishnan K.P.,Research and Development Center | Narayanaswamy N.,Research and Development Center | Subba P.,Mount Carmel College Autonomous | Poornima E.H.,Mount Carmel College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2011

The present investigation was conducted to evaluate the antibacterial efficacy of five medicinal plants against Propionibacterium acnes. The various solvent extracts of herbs namely Azadirachta indica, Vitex negundo, Annona squamosa, Cymbopogon citratus and Terminalia chebula were prepared by decoction method. The antiacne potential of various solvent extracts of herbs were tested along with the standard Clindamycin in a dose dependant manner by disc diffusion method. The results of the study found that aqueous and ethanolic extracts of Terminalia chebula exhibited the outstanding antiacne activity when compared to all other herbal extracts. Moderate zone of inhibition was observed in the medicinal plants namely Azadirachta indica, Vitex negundo and Annona squamosa. Inhibition zone was not detectable in any of the solvent extracts of Cymbopogon citratus. The findings of this study have identified that Terminalia chebula acts as the promising source of antiacne agent which could be useful in the treatment of acne vulgaris.

Amrita G.,Mount Carmel College Autonomous | Greeshma N.,Mount Carmel College Autonomous | Deepa M.,Mount Carmel College Autonomous | Poornima E.H.,Mount Carmel College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2012

Acne vulgaris (Acne) is the most common skin disorder characterized by noninflammatory comedones or inflammatory papules, pustules and nodules. Although acne does not pose serious threat to general health, it is one of the most socially distressing conditions especially for adolescents. The acne inflammation is triggered by pus forming bacteria recognized as Propionibacterium acnes and Staphylococcus epidermidis. Acne therapy includes prolonged use of comedolytic agents, antibiotics and anti-inflammatory agents that are known to cause many side effects. Moreover, the widespread and long-term use of antibiotics over the years has unfortunately led to emergence of resistant strains. To avoid side effects, traditional or herbal formulations are preferred. Herbs are safe, efficacious and multifunctional. Medicinal plant extracts are known to have enormous therapeutic potential. Plant-based preparations with little or no side effects are cyclically returning to complement dermatological therapy. They serve as safer choice or in some cases is the only effective treatment.

Raju A.U.,Mount Carmel College Autonomous | Balakrishnan J.,Bangalore University
Proceedings of 2014 International Conference on Contemporary Computing and Informatics, IC3I 2014 | Year: 2014

The Method of Moments (MoM) when applied for scattering analysis of a large body, generates a dense matrix. In this paper, a sparse matrix is generated from the dense matrix. The thresholding elemental method is applied to obtain a sparse matrix, by assuming that the electromagnetic interaction between sufficiently far away elements is zero. This technique is applied to compute the bistatic radar cross section (RCS) of canonical shapes and a complex shaped aircraft. It is found that for a maximum inaccuracy of 2 dBm2 in RCS, the amount of sparsity generated can be in the range of 40 to 75%, and the corresponding CPU time saving will be of the order of 8 to 34% for objects of different size. It is also observed from the analysis, that with increasing electrical size of the scatterer, the sparsity and hence saving in CPU time increases. © 2014 IEEE.

Chandrani D.,Mount Carmel College Autonomous | Lubaina S.Z.,Mount Carmel College Autonomous | Soosamma M.,Mount Carmel College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2012

Flaking of the scalp is a symptom of seborrhoeic dermatitis, also called dandruff. It frequently occurs around the folds of the nose and eyebrows in addition to the scalp. The epidermal layers of the scalp are continually replaced and the cells are pushed outwards and they flake off giving white or grayish patches on the scalp, skin and clothes. Oily scalp, hormones or a fungus Malassezia seems to be the cause of dandruff. Dandruff can be treated with over the counter products, which are shampoos containing antifungal and antibacterial ingredients like zinc-pyrithione and selenium sulfide, salicylic acid etc. These can only slow down the flaking. Herbal extracts have proved to be good alternatives for the chemical preparations. A number of herbal shampoos and polyherbal hair oils have excellent results due to their synergistic, antifungal, anti-inflammatory and immunostimulatory action.

Sarika K.M.,Mount Carmel College | Aparajita V.,Mount Carmel College | Rani B.,Mount Carmel College | Soosamma M.,Mount Carmel College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2013

Malassezia furfur, is a dermatophilic fungi that utilizes the secretions of the sebaceous glands for its growth and causes infections like dandruffand associated secondary infections. Herbal based treatments for dandruffare now gaining more significance over the conventional synthetic anti-dandruffremedies. In our study, efficacy of 23 medicinal plants for their antifungal activity was evaluated. Aqueous and ethanolic herbal extracts were used for the assay. The Minimum Inhibitory Concentration or MIC was determined as per guidelines laid down by Clinical and Laboratory Standards Institute and the antifungal activity was assayed by well diffusion method. In our study Malassezia furfur was found to be most susceptible to the aqueous extracts of Eugenia jambolana and least susceptible to Terminalia paniculata and among the ethanolic extracts it was most susceptible to Quisqualis indica and least susceptible to Terminalia paniculata.

Jayaramaiah J.R.,Government First Grade College | Shamanth R.,Vijaya Vittala Institute of Technology | Jayanth V.,Siddaganga Institute of Technology | Shamala K.S.,Mount Carmel College Autonomous
Current Applied Physics | Year: 2016

Optical investigation on blue shift behavior of zinc doped cadmium sulphide nano-crystalline thin films have been prepared by spray pyrolysis method at 375 ± 10°C. The crystallinity and phase have been characterized by glancing angle X-ray diffraction. The XRD peaks confirm the hexagonal structure of cadmium sulphide. The crystallites sizes are found its range of 15-20 nm. The surface morphology is analyzed by using field emission scanning electron microscopy. The morphology of the film is seen as uniform distribution of homogeneous fine solid grains which are compact in nature. Optical absorption spectrum reveals an absorption peak at 475 nm. Indicating that blue shift due to quantum confinement effect, as a result the direct energy gap is increased and found its value is 2.91 eV. Raman spectrum reveals the longitudinal optical phonon peaks are at 302 cm-1 and 603 cm-1. The noticeable asymmetry and frequency shift confirm the decrease in particle size. X-ray photoelectron spectroscopy reveals the surface composition and binding energy of elements and it confirm the presence of zinc. The photoluminescence spectrum reveals an emission peak at 728 nm is analyzed. Zn doped cadmium sulphide thin film is useful for window material in solar cells and luminescent red phosphor. © 2016 Elsevier B.V. All rights reserved.

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