New York, NEW YORK, United States
New York, NEW YORK, United States

Motilal Nehru was an Indian lawyer, an activist of the Indian National Movement and an important leader of the Indian National Congress, who also served as the Congress President twice, 1919–1920 and 1928–1929. He was the founder patriarch of India's most powerful political family, the Nehru-Gandhi family. Wikipedia.

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Plants are the integral part of the traditional indigenous healthcare system and are becoming concrete source of new drug discovery, evident by the increasing numbers of modern drugs derived from the phytochemicals. Emblica officinalis Gaertn. or Phyllanthus emblica Linn (family Phyllanthaceae) has been explained extensively and well documented for its therapeutic efficacies in indigenous system of medicine, in India. Every part of this plant possesses high medicinal value but fruits are the most valuable part in folklore and therapeutic uses. The polyphenols found in E.officinalis, especially tannins and flavonoids are key responsible elements for major bioactivities. E.officinalis is one of the major component in various health tonics, also exerts synergistic effects in enhancing the medicinal efficacy. E.officinalis exhibits broad spectrum of pharmacological activities through various mode of actions including antioxidant, anticancer, immunomodulator, anti-inflammatory, cyto-protective properties etc. Medical practitioners across the globe also advocated its application in managing diabetes, dyslipidemia, obesity, several types of cancer, liver disorders, arthritis, gingivitis, wound healing etc. The present review analysed and summarized the pharmacological actions, experimental studies and clinical trials of E. officinalis with emphasis on its immuno-enhancer, antiinflammatory and anticancer activities and possible mechanism of actions to provide future directions in translating these findings clinically. © 2017 Elsevier Masson SAS


Yadav S.,MOTI | Rawal G.,Max Super Specialty Hospital
Translational Pediatrics | Year: 2017

The developing countries are having a number of public health issues. The situation in these resource-limited countries is scary due to the huge burden of infectious diseases like tuberculosis (TB). The latest reports from the WHO shows a high number of drug resistant cases even in the pediatric age groups. Also, the lack of suspicion of drug resistant TB (DR-TB) in the pediatric cases, especially in the absence of a past or family history may lead to delay in diagnosis and?aring-up of the disease. We herein present the very frst case of the primary multidrug-resistant TB in an HIV negative child who presented with the left sided pleural effusion. © Translational Pediatrics. All rights reserved.


Mehrotra R.,MOTI
Indian journal of cancer | Year: 2010

Beginning with the Cigarettes Act, 1975, a number of legislative strategies and programs to curb tobacco use have been implemented in India, with limited success. Currently, the Cigarettes and Other Tobacco Products Act, 2003, is designed to curb the use of tobacco in order to protect and promote public health. This review presents a critical appraisal of the current situation in its historical context.


Mehrotra R.,MOTI
Diagnostic Cytopathology | Year: 2012

Historically, sensitivity and specificity of oral cytology is poor. Using conventional oral cytology for the diagnosis of cancer and its precursors has not had the success that cytologists had hoped for; however, with improved methodology, oral cytology has enjoyed a resurgence of interest. This renewed interest is partly due to the introduction of a specialized brush that collects a full-thickness epithelial sample and not just superficially sloughed cells, as well as analysis of that sample with computer assistance; in addition, a variety of adjunctive techniques have been introduced to potentially enhance the diagnosis of the cytologic specimens including DNA analysis, immunocytochemistry, molecular analysis, and liquid-based preparations. An increase in sensitivity (>96%) and specificity (>90%) of the oral brush biopsy with computer-assisted diagnosis has been reported for identification of malignant and premalignant lesions. Brush cytology is valuable to prevent misdiagnosing doubtful oral lesions, i.e., those lesions without a definitive etiology, diagnosing large lesions where excision of the entire tissue is not possible or practicable, evaluating patients with recurrent malignancies, and monitoring premalignant lesions. Diagn. Cytopathol. 2012; © 2011 Wiley Periodicals, Inc.


Pandey S.,MOTI
Journal of orthopaedic surgery (Hong Kong) | Year: 2013

To compare outcomes of different conservative treatments for flatfoot using the foot print index and valgus index. 150 symptomatic flatfoot patients and 50 controls (without any flatfoot or lower limb deformity) aged older than 8 years were evaluated. The diagnosis was based on pain during walking a distance, the great toe extension test, the valgus index, the foot print index (FPI), as well as eversion/ inversion and dorsiflexion at the ankle. The patients were unequally randomised into 4 treatment groups: (1) foot exercises (n=60), (2) use of the Thomas crooked and elongated heel with or without arch support (n=45), (3) use of the Rose Schwartz insoles (n=18), and (4) foot exercises combined with both footwear modifications (n=27). Of the 150 symptomatic flatfoot patients, 96 had severe flatfoot (FPI, >75) and 54 had incipient flatfoot (FPI, 45-74). The great toe extension test was positive in all 50 controls and 144 patients, and negative in 6 patients (p=0.1734, one-tailed test), which yielded a sensitivity of 96% and a positive predictive value of 74%. Symptoms correlated with the FPI (Chi squared=9.7, p=0.0213). Combining foot exercises and foot wear modifications achieved best outcome in terms of pain relief, gait improvement, and decrease in the FPI and valgus index. The great toe extension test was the best screening tool. The FPI was a good tool for diagnosing and grading of flatfoot and evaluating treatment progress. Combining foot exercises and foot wear modifications achieved the best outcome.


Mehrotra R.,MOTI | Gupta D.K.,Allahabad University | Gupta D.K.,University of Bologna
Head and Neck Oncology | Year: 2011

The prognosis for patients with oral squamous cell carcinoma remains poor in spite of advances in therapy of many other malignancies. Early diagnosis and treatment remains the key to improved patient survival. Because the scalpel biopsy for diagnosis is invasive and has potential morbidity, it is reserved for evaluating highly suspicious lesions and not for the majority of oral lesions which are clinically not suspicious. Furthermore, scalpel biopsy has significant interobserver and intraobserver variability in the histologic diagnosis of dysplasia. There is an urgent need to devise critical diagnostic tools for early detection of oral dysplasia and malignancy that are practical, noninvasive and can be easily performed in an out-patient set-up. Diagnostic tests for early detection include brush biopsy, toluidine blue staining, autofluorescence, salivary proteomics, DNA analysis, biomarkers and spectroscopy. This state of the art review critically examines these tests and assesses their value in identifying oral squamous cell carcinoma and its precursor lesions. © 2011 Mehrotra and Gupta; licensee BioMed Central Ltd.


Patent
Moti | Date: 2014-02-12

This document generally describes techniques, methods, systems, and computer program products for providing a three-dimensional (3D) sports playbook. Such a playbook may permit someone like a football, basketball, or soccer coach to see a play executed in a classic Xs and Os overhead two-dimensional (2D) view, and also in a 3D view.


Patent
Moti | Date: 2016-05-12

This document generally describes techniques, methods, systems, and computer program products for providing a three-dimensional (3D) sports playbook. Such a playbook may permit someone like a football, basketball, or soccer coach to see a play executed in a classic Xs and Os overhead two-dimensional (2D) view, and also in a 3D view.


News Article | January 8, 2016
Site: www.fastcompany.com

By mid-January, there's a decent chance your New Year's resolution will be a distant memory. But a new gadget, based on the latest behavioral science about how our brains form habits, might change that. I started testing a beta version of the tiny robot, called MOTI, last month. It's deceptively simple: You pick a habit and, using a web-based interface, tell MOTI when and how often you want to do it each day. On cue, the device starts to flash and buzz as a reminder. When you've done whatever you're supposed to do—like go for a run—you push a button on the front, and it flashes and buzzes again in celebration. There's brain science behind why this works. To stick, habits need both a trigger and a reward. Because the robot sits on your desktop—always visible, unlike an app on your phone—it's a constant reminder of your goal. The flashing and buzzing act as the final trigger, and pushing the button provides an immediate (if cursory) reward, something that most good habits lack. "The moment of 'yes I did the thing' that the push-button provides gives your brain the shot of dopamine it craves," says Kayla Matheus, MOTI's designer. "But, you have to make sure to vary it up so people don't get complacent." Over time, the patterns and colors change, and the company also plans to offer external rewards. As a robot, it's also designed to add a little artificial social pressure. "This is why MOTI is admittedly cute," she says. "It's why his faceplate looks like an eye (the most important feature for anthropomorphization), and he has little feet. Users need to develop a relationship with their MOTI to get its pseudo-social effects that have been studied in academia for years." The device also only supports a single habit at once, something that also comes from research. While I was tempted to take on a new yoga routine, overhaul my eating habits, and do some financial planning, I had to pick just one to start. I started with something simple: After writing countless articles about the dangers of sitting all day at work, I hadn't been able to motivate myself to stand. When I told the MOTI website that I wanted to try standing up, it suggested that I pick specific times—linking the action to a time of day helps make it a routine. The goal was easy enough that it's achievable; instead of trying to stand all day, I just stand up twice a day, and then sit down when I get distracted. So far, it's worked. By next New Year's Day, the gadget should be on the market. The designers just finished taking the device through a hardware accelerator program called Highway1, and after some final tweaks, they plan to launch a crowdfunding campaign later this year. In the meantime, a few pilot units are available to try out here.

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