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Balachandiran M.,Mother Theresa Postgraduate and Research Institute of Health science | Selvakumar C.,Meenakshi Medical College and Research Institute | Sridhar M.G.,Jawaharlal Institute of Postgraduate Medical Education & Research
International Journal of Pharma and Bio Sciences | Year: 2012

Platelet aggregation is the one of the initial haemostatic events that stops bleeding resulting from a vascular injury. It has been observed that increased collagen induced platelet aggregation in acute ischemic stroke patients. In view of the above, the present study was planned to determine the above said parameter in acute ischemic stroke patients. A total number of 60 subjects participated in the present study which included 30 acute ischemic stroke cases and 30 controls. Fasting plasma glucose, lipid profile, Plasma fibrinogen, Platelet aggregation were estimated. Platelet aggregation was significantly lower in cases (acute ischemic stroke) as compared to controls; whereas collagen induced platelet aggregation and plasma fibrinogen were significantly higher in cases. No significant differences were found in triglycerides, HDL-cholesterol, VLDL, TG/HDL and Atherogenic Index. In present study we found an increased collagen induced platelet aggregation which is induced by plasma fibrinogen and positive correlation between atherogenic index and fibrinogen. Source


Chalapathi V.,Mother Theresa Postgraduate and Research Institute of Health science | Yuvaraj T.V.,Mother Theresa Postgraduate and Research Institute of Health science | Jaganathan A.,Accent Pharma
International Journal of ChemTech Research | Year: 2010

Pharmaceutical Manufacturing is an important enterprise and oral tablet Manufacturing is the most significant of all, because more drugs are made as tablets than any other dosage form. The way of tablet Manufacturing has been undergoing change in recent years and is likely to head in new directions. In this study Manihot esculenta (Maravalli kizhangu) a freely available & cheap starch has been chosen as a binder and studied for its effectiveness by comparing with the industrial Maize starch. As a consequence, the requirements for inert ingredients used in tablet Manufacture, in particular the requirements for tablet binders used in wet granulation, are undergoing change as well. A binder play a great role in the determination of disintegration time & dissolution of tablets, choosing of binder & disintegrators is also important. Source


Iyyappan C.,Mother Theresa Postgraduate and Research Institute of Health science | Mounnissamy V.M.,Mother Theresa Postgraduate and Research Institute of Health science
International Journal of Pharma and Bio Sciences | Year: 2011

The present paper deals with the microscopical study of leaf and stem of Dipteracanthus prostrates (poir.), Acanthaceae, for its identification and to distinguish it from the co-existing weeds and adulterants. Source

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