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Nanthini T.,Mother Theresa Post Graduate and Research Institute of Health science | Karunagari K.,Annamalai University
Indian Journal of Occupational and Environmental Medicine | Year: 2016

Introduction: Employees constitute a large and important sector of the worlds population. The global labor force is about 2,600 million and 75% of this force is working in developing countries. Occupational health and safety (OHS) must be managed in every aspect of their work. Occupational safety and health (OSH), also commonly referred to as OHS or workplace health and safety (WHS) is an area concerned with the safety, health, and welfare of people engaged in any employment. The goal of OSH is to foster a safe and healthy work environment. The aim of this study is to evaluate the effectiveness of video-assisted teaching program on safety measures. Materials and Methods: A total of 105 employees were selected from M/s ACE Glass Containers Ltd. at Puducherry, India using the convenience sampling technique. Pretest was conducted using a self-administered questionnaire. Subsequent video-assisted teaching was conducted by the investigator after which posttest was conducted. Results and Conclusion: Video-assisted teaching program was found to be effective in improving the knowledge, attitude, and practice of the subjects. Periodical reorientation on safety measures are needed for all the employees as it is essential for promoting the well-being of employees working in any industry. Source


Saleem M.T.S.,Jawaharlal Nehru Technological University Kakinada | Kavimani S.,Mother Theresa Post Graduate and Research Institute of Health science
Journal of Cardiovascular Disease Research | Year: 2013

Background Sesame oil is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the antioxidant property of chronic oral administration of sesame oil against isoproterenol induced myocardial injury. Methods and results Male Wistar albino rats were randomly divided into five groups (n = 6) and treated as per treatment protocol with two different doses of sesame oil (5 and 10 ml/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group ISO) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Sesame oil in both the dose (group S1 and S2) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD) and Catalase). Sesame oil also increased the lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate transaminase (AST) as a myocardial marker enzyme in heart homogenate. As histologically evident isoproterenol induced myocardial injury was well preserved by the chronic administration of sesame oil. The protective role of sesame oil was compared with the reference standard α-tocopherol (group S3) also showing the similar effect. Conclusion From this finding it has been concluded that chronic administration of sesame oil offers cardio protective action via putative antioxidant property. © 2013, SciBioIMed.Org, Published by Reed Elsevier India Pvt. Ltd. All rights reserved. Source


Saleem M.T.S.,Jawaharlal Nehru Technological University Kakinada | Kavimani S.,Mother Theresa Post Graduate and Research Institute of Health science
Therapeutic Advances in Cardiovascular Disease | Year: 2014

Objective: Oxidative stress is currently considered to be the key factor in doxorubicin-induced cardiotoxicity. Comparatively small quantity of the endogenous antioxidant content of the heart is assumed to be the predisposing factor for doxorubicin-induced cardiotoxicity. The present research was designed to evaluate the antioxidant potential and tumor necrosis factor alpha- (TNF-α) inhibiting activity of sesame oil against acute doxorubicin-induced cardiotoxicity. Methods: Male Wistar albino rats (180-200 g) were administered sesame oil in two dissimilar doses (5 and 10 ml/kg body weight, orally) for 30 days, followed by a single dose of doxorubicin (30 mg/kg s.c.). Results: In the doxorubicin-treated group, increased oxidative stress was proven by a significant rise of thiobarbituric acid reactive substances level and a decrease of myocardial superoxide dismutase, catalase and reduced glutathione content. Histopathological studies showed myocardial necrosis with accumulation of inflammatory cells, vacuolization and overall enlargement of the myocardium. Western blot analysis showed marked expression of TNF-α in the myocardium. Alteration in biochemical parameters by doxorubicin administration was prevented significantly (p < 0.0001) in the 5 and 10 ml/kg sesame oil treated rat hearts. Treatment with 5 and 10 ml/kg of sesame oil reduced the doxorubicin-induced TNF-α expression in the myocardium, which was associated with reduced myocyte injury. The overall effect of sesame oil was comparable with probucol, which shows similar protection. Conclusion: The chronic oral administration of sesame oil prevents acute doxorubicin-induced cardiotoxicity by enhancing cardiac endogenous antioxidants and decreasing myocardial TNF-α expression. © 2014 The Author(s). Source


Yamini K.,Mother Theresa Post Graduate and Research Institute of Health science | Gopal V.,Mother Theresa Post Graduate and Research Institute of Health science
Journal of Applied Pharmaceutical Science | Year: 2011

The present study was done with the aim to evaluate anthelmintic activity of Trikatu churna containing traditionally user herbs viz., Piper nigrum L. (Piperaceae), Piper longum L. (Piperaceae) and rhizome of Zingiber officinale Roscoe using adult earthworm Pheritima posthuma. All these three ingredients are spicy, commonly used in our daily diet, also well known for their tremendous therapeutic potential, since from the Vedic period. The aqueous and ethanolic extract of Trikatu churna and its ingredients were also screened for preliminary phytochemical studies. Piperazine citrate was used as standard and it was found that the TCEE activity is higher than TCAE. Source


Devi K.,Mother Theresa Post Graduate and Research Institute of Health science | Kavimani S.,Mother Theresa Post Graduate and Research Institute of Health science
International Journal of Pharma and Bio Sciences | Year: 2010

Calcium channel blockers are used as effective agent in various disorders of cardiovascular system such as angina, hypertension and arrythmiasis. Calcium ions play a central role in the control of neuronal excitability. Therefore this study was designed to find out the effect of Isradipine on MES and Picrotoxin induced convulsion. The maximal seizure pattern was induced in animals by giving an alternating current of 150 mA for 0.2 sec while tonic - clonic seizure with 2 mg/kg; ip of Picrotoxin. Isradipine (80-g/kg; ip), Phenytoin (25mg/kg; ip), Diazepam (10mg/kg; ip), Phenytoin + Isradipine, and Diazepam + Isradipine were administered 30 min before electrical/chemical induction of convulsion. The ability of test group to abolish/reduce tonic hind limb extensor component in MES group and delay in onset of jerky movement & death time in Picrotoxin induced group was measured as antiepileptic criteria. Isradipine produced significant reduction in the extensor phase when compared with control and also it potentiated the abolition when compared with Phenytoin in MES induced convulsion. Similarly Isradipine delay the onset of action and time of death in Picrotoxin induced convulsion with 100% recovery of animals when combined with Diazepam. The anticonvulsant property may be by blockade of voltage dependent calcium channels by which calcium ions influx is blocked to stop the sequence of events leading to both the spread of epileptic discharge, cell damage and death. Source

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