Mother Theresa Post Graduate Research Institute of Health science

Puducherry, India

Mother Theresa Post Graduate Research Institute of Health science

Puducherry, India

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Thamizhvanan P.,Mother Theresa Post Graduate & Research Institute of Health SciencesPuducherry | Bharathi J.,Mother Theresa Post Graduate & Research Institute of Health science
Bangladesh Journal of Medical Science | Year: 2017

Background and rationale: HDL cholesterol is one of the 5 major groups of lipoproteins cholesterol, which enable lipids like cholesterol and TG to be transported within the water based blood stream. In healthy persons, about thirty percent of blood cholesterol is carried by HDL cholesterol. HDL-C is a potent predictor of coronary heart disease. Genetic as well as environmental factors including lifestyle factors play a role as determinants of its level in the blood. To examine the effects of certain lifestyle factors on serum level of high density lipoprotein cholesterol in young adult people HDL cholesterol seems to protect against CVD which increases the risk for heart disease. Subjects and methods: Three hundred and twenty five young adult subjects of both sexes aged 18-45 years asymptomatic for cardiovascular diseases were interviewed according to special questionnaire including information on lifestyle habits. Physical examination was done, height, body weight, and blood pressure measurements were performed. Blood analysis to determine the blood level of high density lipoprotein cholesterol was done after 12 hours fasting. Results and conclusion: Smoking and obesity were the most significant risk factors associated with a decreased level of high density lipoprotein cholesterol. The level of HDL-C was 50.5±11.5 mg/dl in smokers compared with 57.7±12.5 mg/dl in nonsmokers. Its level was 48.5 ±8.5 mg/dl in obese individuals compared to 57.5±11.7mg/dl in normal body weight subjects. Physical activity was not significantly associated with low level of HDL-C analysis, but it was found to be significantly associated with its level by the multiple regression analysis. High-density lipoprotein cholesterol level was a function of many factors, some of them were lifestyle related such as smoking, physical activity, and obesity. Therefore, efforts to encourage more physical activity, quitting smoking, consuming low fat diet, and keeping ideal body weight are recommended. © 2017, Ibn Sina Trust. All rights reserved.


Mani A.,Sri Ramachandra Medical College and Research Institute | Vasanthi C.,Sri Ramachandra Medical College and Research Institute | Gopal V.,Mother Theresa Post Graduate & Research Institute of Health science | Chellathai D.,Sri Ramachandra Medical College and Research Institute
International Immunopharmacology | Year: 2016

Aim of the study The present study was aimed to evaluate the anti-arthritic effects of silver nanoparticles synthesised using Piper nigrum extract and to further establish its mechanism of action in a rat model of adjuvant induced arthritis (AA). Materials and methods Adjuvant arthritis was induced by injecting complete Freund's adjuvant (0.1 mL) into the left hind paw of 36 albino Wistar rats (n = 6). Silver nanoparticles stabilised with Piper nigrum extract (25 and 50 mg/kg). Commercial silver nanoparticles (50 mg/kg) and methotrexate (0.1 mg/kg) were administered by intraperitoneal route from day 11 to day 22 on alternate days. Results It was found that treatment with silver nanoparticles stabilised with Piper nigrum (S-AgNPs) significantly reduced the paw edema and alleviated the histopathological changes of cell infiltration, synovial hyperplasia, bone and cartilage destruction. Furthermore, the phytostabilised silver nanoparticles (S-AgNPs) inhibited the protein expression of NF-kβ p65 and TNF-α as evidenced by immunohistochemistry analysis. Conclusion Our current findings suggest that silver nanoparticles stabilised with Piper nigrum extract (S-AgNPs) have potent anti-arthritic activity which is mediated by inhibition of TNF-α and suppression of pro-inflammatory cytokines that are secreted in response to activated transcription factors of NF-kβ. © 2016 Elsevier B.V.


PubMed | Mother Theresa Post Graduate & Research Institute of Health science and Sri Ramachandra Medical College and Research Institute
Type: | Journal: International immunopharmacology | Year: 2016

The present study was aimed to evaluate the anti-arthritic effects of silver nanoparticles synthesised using Piper nigrum extract and to further establish its mechanism of action in a rat model of adjuvant induced arthritis (AA).Adjuvant arthritis was induced by injecting complete Freunds adjuvant (0.1mL) into the left hind paw of 36 albino Wistar rats (n=6). Silver nanoparticles stabilised with Piper nigrum extract (25 and 50mg/kg). Commercial silver nanoparticles (50mg/kg) and methotrexate (0.1mg/kg) were administered by intraperitoneal route from day 11 to day 22 on alternate days.It was found that treatment with silver nanoparticles stabilised with Piper nigrum (S-AgNPs) significantly reduced the paw edema and alleviated the histopathological changes of cell infiltration, synovial hyperplasia, bone and cartilage destruction. Furthermore, the phytostabilised silver nanoparticles (S-AgNPs) inhibited the protein expression of NF-k p65 and TNF- as evidenced by immunohistochemistry analysis.Our current findings suggest that silver nanoparticles stabilised with Piper nigrum extract (S-AgNPs) have potent anti-arthritic activity which is mediated by inhibition of TNF- and suppression of pro-inflammatory cytokines that are secreted in response to activated transcription factors of NF-k.


Prabavathy N.,Mother Theresa Post Graduate Research Institute of Health science | Vijayakumari M.,Mother Theresa Post Graduate Research Institute of Health science | Minil M.,Mother Theresa Post Graduate Research Institute of Health science | Sathiyaraj U.,Mother Theresa Post Graduate Research Institute of Health science | Kavimani S.,Mother Theresa Post Graduate Research Institute of Health science
International Journal of Pharma and Bio Sciences | Year: 2011

Although glycemic control is an important and effective way to prevent and minimize the worsening of diabetes-related complications, type 2 diabetes is a progressive disease which often proves difficult to manage. Most affected patients will eventually require therapy with multiple medications in order to reach appropriate glycemic targets. The dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a relatively new class of oral medications for the treatment of type 2 diabetes, which has become widely incorporated into clinical practice. Linagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor in clinical development for the treatment of type 2 diabetes. It exhibits non-linear pharmacokinetics and shows concentrationdependent plasma protein binding to its target, DPP-4.


PubMed | Mother Theresa Post Graduate & Research Institute of Health science
Type: Journal Article | Journal: Cardiopulmonary physical therapy journal | Year: 2010

Tuberculosis is an infectious disease that affects the lungs and results in poor lung compliance secondary to diffuse fibrotic changes to lung tissue. Consequently, people with pulmonary tuberculosis experience impaired gas exchange resulting in a decline in functional capacity. The purpose of this study was to evaluate the physical functional capacity (VO(2)max) in a group of older (50 - 65 years) people with pulmonary tuberculosis and to compare them to an age-matched healthy group. A secondary purpose was to develop reference equations that could be used to predict 6 minute walk test (6MWT) distance in older, healthy people in India.Sixty healthy subjects (30 male and 30 female) and 60 subjects with a diagnosis of pulmonary tuberculosis (30 male and 30 female) participated in the study. All subjects underwent a 6MWT. Walk-work was calculated and used for evaluating functional capacity. Group comparison for functional capacity was done using 2-tailed t-tests. Pearson product correlation was used to examine for significant relationships and regression analysis was used to derive reference equations.There was a significant difference between groups in regard to functional capacity and 6MWT distance (p < 0.001). Reference equations were developed that use age, height, and weight as predictors for 6MWT distance in the healthy group.The sequelae from pulmonary tuberculosis have considerable impact on functional capacity in older people in India.

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