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Saleem M.T.S.,Jawaharlal Nehru Technological University Kakinada | Kavimani S.,Mother Theresa Post Graduate and Research Institute of Health science
Therapeutic Advances in Cardiovascular Disease | Year: 2014

Objective: Oxidative stress is currently considered to be the key factor in doxorubicin-induced cardiotoxicity. Comparatively small quantity of the endogenous antioxidant content of the heart is assumed to be the predisposing factor for doxorubicin-induced cardiotoxicity. The present research was designed to evaluate the antioxidant potential and tumor necrosis factor alpha- (TNF-α) inhibiting activity of sesame oil against acute doxorubicin-induced cardiotoxicity. Methods: Male Wistar albino rats (180-200 g) were administered sesame oil in two dissimilar doses (5 and 10 ml/kg body weight, orally) for 30 days, followed by a single dose of doxorubicin (30 mg/kg s.c.). Results: In the doxorubicin-treated group, increased oxidative stress was proven by a significant rise of thiobarbituric acid reactive substances level and a decrease of myocardial superoxide dismutase, catalase and reduced glutathione content. Histopathological studies showed myocardial necrosis with accumulation of inflammatory cells, vacuolization and overall enlargement of the myocardium. Western blot analysis showed marked expression of TNF-α in the myocardium. Alteration in biochemical parameters by doxorubicin administration was prevented significantly (p < 0.0001) in the 5 and 10 ml/kg sesame oil treated rat hearts. Treatment with 5 and 10 ml/kg of sesame oil reduced the doxorubicin-induced TNF-α expression in the myocardium, which was associated with reduced myocyte injury. The overall effect of sesame oil was comparable with probucol, which shows similar protection. Conclusion: The chronic oral administration of sesame oil prevents acute doxorubicin-induced cardiotoxicity by enhancing cardiac endogenous antioxidants and decreasing myocardial TNF-α expression. © 2014 The Author(s).


Saleem M.T.S.,Jawaharlal Nehru Technological University Kakinada | Kavimani S.,Mother Theresa Post Graduate and Research Institute of Health science
Journal of Cardiovascular Disease Research | Year: 2013

Background Sesame oil is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the antioxidant property of chronic oral administration of sesame oil against isoproterenol induced myocardial injury. Methods and results Male Wistar albino rats were randomly divided into five groups (n = 6) and treated as per treatment protocol with two different doses of sesame oil (5 and 10 ml/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group ISO) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Sesame oil in both the dose (group S1 and S2) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD) and Catalase). Sesame oil also increased the lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate transaminase (AST) as a myocardial marker enzyme in heart homogenate. As histologically evident isoproterenol induced myocardial injury was well preserved by the chronic administration of sesame oil. The protective role of sesame oil was compared with the reference standard α-tocopherol (group S3) also showing the similar effect. Conclusion From this finding it has been concluded that chronic administration of sesame oil offers cardio protective action via putative antioxidant property. © 2013, SciBioIMed.Org, Published by Reed Elsevier India Pvt. Ltd. All rights reserved.


PubMed | Sri Ramachandra University, Sri Ramachandra Medical Center and Mother Theresa Post Graduate and Research Institute of Health science
Type: Journal Article | Journal: Annals of medical and health sciences research | Year: 2016

Malnutrition and inflammation are associated with morbidity and mortality in patients on maintenance hemodialysis (MHD). Ghrelin, an orexigenic peptide hormone, is speculated to be associated with nutritional and inflammatory status in MHD.To assess the serum total ghrelin levels and its possible relationship with inflammation and nutritional status in patients on MHD.The study was conducted on 90 patients on MHD for 6 months and above (56 males, 34 females, mean age 52.6 [11.7] years; mean dialysis vintage 20.9 [12.1] months) and 70 healthy volunteers as control (5 males, 25 females, mean age 50.6 [9.7] years). Demographics were obtained for the study population, and dialysis-related data were collected for cases. Anthropometry, biochemical parameters, serum total ghrelin and inflammatory markers tumor necrosis factor-alpha (TNF-), and high-sensitivityC-reactive protein (hsCRP) were assessed for cases and control. Self-reported appetite (five questions of appetite and diet assessment tool) and nutritional status (subjective global assessment-dialysis malnutrition score) were assessed for cases.Ghrelin (242.5 [62.3] pg/mL vs. 80.2 [19.6] pg/mL; P < 0.001), TNF- (39.8 [15.2] pg/mL vs. 6.5 [1.2] pg/mL; P < 0.001), hsCRP (10.2 [2.8] mg/L vs. 2.7 [0.54] mg/L; P < 0.001) were significantly elevated in cases versus control, anthropometry, and biochemical parameters were significantly decreased in hemodialysis patient. Of 90 cases, (13/90 [14.4%]) were well-nourished, (28/90 [31%]) mild to moderately malnourished, and (49/90 [54.4%]) were moderate to severely malnourished. Appetite was very good for14.4%, good and fair for 47.8%, poor and very poor for 37.8% patients. There was a significant difference in appetite with respect to nutritional status (P < 0.001). Ghrelin had positive correlation with inflammatory markers and negative correlation with nutritional status (P < 0.001).The study identified the association of ghrelin with appetite, nutritional, and inflammatory status of the patients on MHD.


PubMed | Hospital & Research Center, Indira Gandhi Institute of Dental science IGIDS, Mother Theresa Post Graduate and Research Institute of Health science and Mahatma Gandhi Institute
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, which hamper the quality of life. There are no sensitive and specific markers to predict these complications at the earliest. Sialochemistry has recently gained attention for monitoring chronic diseases. Osteopontin is a phospho-glycoprotein molecule, elevated in many inflammatory conditions.The aim of the study was to evaluate the role of serum and salivary osteopontin in Type 2 Diabetes mellitus (T2DM).In this case-control study, we recruited 33 cases of T2DM and 31 age and gender matched healthy controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR), Waist Circumference (WC) and blood pressure was recorded. Fasting Plasma Glucose (FPG), salivary glucose, HbA1c, microalbuminuria, systolic BP, serum and salivary osteopontin levels were estimated.FPG, salivary glucose, HbA1c, microalbuminuria, systolic BP, BMI, waist / hip ratio serum and salivary osteopontin levels were significantly high in T2DM cases compared to control subjects. Serum and salivary osteopontin levels were significantly correlated with HbA1c and microalbuminuria in T2DM cases.Serum and salivary osteopontin levels are significantly elevated in subjects with T2DM and are associated with glycaemic control and microalbuminuria.


Nanthini T.,Mother Theresa Post Graduate and Research Institute of Health science | Karunagari K.,Annamalai University
Indian Journal of Occupational and Environmental Medicine | Year: 2016

Introduction: Employees constitute a large and important sector of the worlds population. The global labor force is about 2,600 million and 75% of this force is working in developing countries. Occupational health and safety (OHS) must be managed in every aspect of their work. Occupational safety and health (OSH), also commonly referred to as OHS or workplace health and safety (WHS) is an area concerned with the safety, health, and welfare of people engaged in any employment. The goal of OSH is to foster a safe and healthy work environment. The aim of this study is to evaluate the effectiveness of video-assisted teaching program on safety measures. Materials and Methods: A total of 105 employees were selected from M/s ACE Glass Containers Ltd. at Puducherry, India using the convenience sampling technique. Pretest was conducted using a self-administered questionnaire. Subsequent video-assisted teaching was conducted by the investigator after which posttest was conducted. Results and Conclusion: Video-assisted teaching program was found to be effective in improving the knowledge, attitude, and practice of the subjects. Periodical reorientation on safety measures are needed for all the employees as it is essential for promoting the well-being of employees working in any industry.


PubMed | Mother Theresa Post graduate and research institute of health science and Western Michigan University
Type: | Journal: European journal of internal medicine | Year: 2016

A 64year old man presented with atypical chest pain of 6h duration. Physical examination showed tachycardia and an irregularly irregular pulse. Initial EKG showed atrial fibrillation with rapid ventricular rate. Intravenous Diltiazem was administered following which there was resolution of atrial fibrillation as well as his chest pain. Troponin T and CPK-MB were minimally elevated at 0.05ng/ml (0.0-0.03ng/ml) and 8.6ng/ml (0.0-7.0ng/ml) respectively. A repeat EKG obtained after symptom resolution showed biphasic T wave inversions in V2 and V3 which prompted an emergent coronary angiogram that revealed 90% occlusion of the proximal LAD. The immediate recognition of Wellens pattern lead to emergent coronary revascularization and prevention of acute myocardial infarction in our patient. Clinicians should be aware of this syndrome so that prompt invasive therapy can be done to avoid evolution into MI and subsequent left ventricular dysfunction.


PubMed | Michigan State University, Mother Theresa Post Graduate and Research Institute Of Health science and Western Michigan University
Type: | Journal: International journal of cardiology | Year: 2016

Pulmonary embolism (PE) is a serious medical condition associated with major morbidity, mortality and economic burden. Preventable hospital readmissions are a major economic challenge for the healthcare organizations and identifying patient subsets at risk of readmission will help report the issue. This retrospective study was performed to determine demographic parameters and major diagnosis linked with 30day readmission after a PE.Nationwide Inpatient Sample (NIS) data was used to extract data of patients discharged after PE during index admission for years 2009-2013. Patients were identified by Diagnosis Related Group (DRG) number 175 and 176 which represents PE with major complications and comorbidities (MCC) and PE without MCC. Demographic parameters associated with high readmission rate were identified along with causes related to readmissions.We identified a total of 650,819 hospitalizations with PE as the index stay DRG of which 13.44% were readmitted within 30 days after hospitalizations. Patients with age >65years (14.05%), female (13.87%), Medicaid insurances (20.49%), low median income for zip code (15.1%) and metropolitan areas (13.71%) were associated with higher 30day readmission rates. The most common identified cause of readmission in PE with MCC from 2009 to 2010 was heart failure (4.25%) and from 2011 to 2013 was severe sepsis (4.8%) while for PE without MCC from 2009 to 2013 was PE without MCC itself (10.24%).Interventions need to be directed against these set of patients and the identified causes of readmissions to reduce the rehospitalisations from PE.


Praveen C.,CSIR - Central Leather Research Institute | Iyyappan C.,Mother Theresa Post Graduate and Research Institute of Health science | Girija K.,Mother Theresa Post Graduate and Research Institute of Health science | Kumar K.S.,Pondicherry University | Perumal P.T.,CSIR - Central Leather Research Institute
Journal of Chemical Sciences | Year: 2012

3-Alkylidene-1,3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs. [Figure not available: see fulltext.] © 2011 Indian Academy of Sciences.


Badmapriya D.,Government General Hospital | Rajalakshmi A.N.,Mother Theresa Post Graduate and Research Institute of Health science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A novel 5-Aminosalicylic acid matrix tablets was developed using guar gum for colon targeting coated with two different polymeric layers to protect the matrix tablets from gastrointestinal environment. The in-vitro drug release was conducted in 0.1N HCl for 2 hours indicated no change in the enteric coating. This showed that the enteric coating membrane prevented inner film coat from erosion or pore forming. The medium was replaced with phosphate buffer pH 6.8 for 3 hours and at the end of 3 hour, the enteric coating was dissolved. The test was continued for 7 hours by replacing the medium with phosphate buffer pH 7.4 containing 4% rat cecael content, the drug was released in the range of 57.8 to 68.38%, due to the microbial enzymatic activity and therefore site specificity of the dosage form consequently sustained the release of the drug over a period of 12 hours. Among the four formulated batches, batch I had retarded release of about 57.8% at 12 th hours with that of other batches, hence batch I sustain the release up to 100% over 24 hours. The results showed that developed guar gum based formulation had a high potential for colonic drug delivery.


Devi K.,Mother Theresa Post Graduate and Research Institute of Health science | Kavimani S.,Mother Theresa Post Graduate and Research Institute of Health science
International Journal of Pharma and Bio Sciences | Year: 2010

Calcium channel blockers are used as effective agent in various disorders of cardiovascular system such as angina, hypertension and arrythmiasis. Calcium ions play a central role in the control of neuronal excitability. Therefore this study was designed to find out the effect of Isradipine on MES and Picrotoxin induced convulsion. The maximal seizure pattern was induced in animals by giving an alternating current of 150 mA for 0.2 sec while tonic - clonic seizure with 2 mg/kg; ip of Picrotoxin. Isradipine (80-g/kg; ip), Phenytoin (25mg/kg; ip), Diazepam (10mg/kg; ip), Phenytoin + Isradipine, and Diazepam + Isradipine were administered 30 min before electrical/chemical induction of convulsion. The ability of test group to abolish/reduce tonic hind limb extensor component in MES group and delay in onset of jerky movement & death time in Picrotoxin induced group was measured as antiepileptic criteria. Isradipine produced significant reduction in the extensor phase when compared with control and also it potentiated the abolition when compared with Phenytoin in MES induced convulsion. Similarly Isradipine delay the onset of action and time of death in Picrotoxin induced convulsion with 100% recovery of animals when combined with Diazepam. The anticonvulsant property may be by blockade of voltage dependent calcium channels by which calcium ions influx is blocked to stop the sequence of events leading to both the spread of epileptic discharge, cell damage and death.

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