Gopal V.,Mother Theresa Institute of Health science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010
A polyherbal formulation is investigated for hepatoprotective activity against carbon tetrachloride induced hepatic damage in female albino Wister rats. The hepatoprotective activity of polyherbal formulation is compared with the standard drug Liv-52.The polyherbal formulation has shown significant hepatoprotective activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase(SGOT) to 86.96 IU/L, serum glutamate pyruvate transaminase(SGPT) to 47.62 IU/L, alkaline phosphate(ALP) to 446 IU/L, Bilirubin level to 0.57 mg/dl and significant increase in total protein and albumin 9.5 g/dl and 7.74 g/dl respectively when compared to the standard drug Liv-52 which decreased SGOT to 89.40U/LSGPT to 49.49 IU/L, ALKP to 509 IU/L, Bilirubin level to 0.57 mg/dl and increased total protein and albumin levels to 9.5 gm/dl and 7.14 gm/dl respectively against carbon tetrachloride intoxicated rats in comparison to normal control. These biochemical observations were also supplemented by histopathological examinations of the liver sections. The results showed that polyherbal formulation was most active.
Kavimani S.,Mother Theresa Institute of Health science |
Shakil Sait S.,Dr. Reddys laboratories Pvt. Ltd
Der Pharmacia Lettre | Year: 2013
Food-drug interaction is a challenging concept, since the consumption of food and other herbal drugs is not documented in patient's profile. With this aspect the present study was designed to investigate the possible effect of Pineapple juice on glimepiride (substrate for CYP2C9) an oral hypoglycemic drug in wistar albino rats. Relative to the standard group (glimepiride 1mg/kg alone treated), the reduction of blood glucose level of test group (Pineapple juice 3mL+glimepiride 1mg/kg treated) was more in both acute and sub-acute in alloxan induced diabetic rats when Pineapple juice (3 mL) was injected p.o.1 h before the p.o. administration of the glimepiride (1mg/kg). These results suggest Pineapple juice ingestion increases the efficacy of glimepiride may be by inhibiting intestinal CYP2C9 enzyme in albino wistar rats.
Patil J.,PRIST University |
Kadam C.,Mother Theresa Institute of Health science |
Vishwajith V.,Mother Theresa Institute of Health science |
Gopal V.,PRIST University |
Gopal V.,Mother Theresa Institute of Health science
International Journal of Pharma and Bio Sciences | Year: 2011
The present work aims to formulate and design orally disintegrating tablets containing antihistamines like Loratadine using different pharmaceutical compositions with simple manufacturing procedures to enhance patient compliance. Loratadine was formulated into orally disintegrating tablets by direct compression method using suitable excipients like Maltodextrin, Mannitol, Micro crystalline cellulose, combination of Mannitol with Starch, Croscarmellose sodium, Citric acid, Sodium bicarbonate along with Mint flavor, which were evaluated by using simple analytical techniques. The taste of the formulation was enhanced using artificial sweetener Aspartame and Mint flavour. The tablets were evaluated for weight variation, hardness, friability, drug content, wetting time and disintegration time along with invitro dissolution. It was observed that the direct compression process using commercial grades of excipients like combination of Mannitol with Starch and Micro crystalline cellulose as directly compressible diluents along with super disintegrants like Croscarmellose Sodium was found to be more promising to prepare orally disintegrating tablets.
Kayarohanam S.,Jawaharlal Nehru University |
Kavimani S.,Mother Theresa Institute of Health science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015
Objective: The present study was to evaluate the oral toxicity of acute and sub acute studies of methanol leaf and bark extract of Dolichandrone atrovirens Methods: In acute toxicity studies of aqueous methanolic Dolichandrone atrovirens leaf extract(DALE) and Dolichandrone atrovirens bark extracts (DABE) (in 0.3% sodium CMC) as a single dose (2000 mg/kg) was administered to the Swiss albino mice (20-25 g) by oral route and the animals were observed for mortality and any toxic symptoms up to 14 days. In sub acute toxicity studies the DALE and DABE were administered daily for 28 days at doses ranging from 200-400 mg/kg. The animals were found in signs of toxicity, morbidity and mortality for 28 days. The animals were submitted to observe the serum biochemical markers and weight of the vital organs. Results: The results of 14 days acute toxicity studies up to a dose of 2000 mg/kg of the aqueous methanolic DABE and DALE neither produced mortality nor shows any symptoms of behavior or any physiological changes in body weight, food and water intake. 28 days sub acute studies repeated doses of oral toxicity did not show any toxic signs or any mortality when three doses 200 and 400 mg/kg of the methanolic leaf and bark extracts of Dolichandrone atrovirens administered. No significant changes were integrated in biochemical and hematological parameters when compared with the control group. Conclusion: From the results it is concluded that the dose at 400 mg/kg is safe for long term treatment in diabetic conditions. © 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All Rights Reserved.
Sangeetha M.,Sri Ramachandra University |
Chamundeeswari D.,Sri Ramachandra University |
Saravana Babu C.,Sri Ramachandra University |
Rose C.,CSIR - Central Leather Research Institute |
Gopal V.,Mother Theresa institute of Health science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013
Albizia procera belongs to the family mimosaceae, found in the sub-Himalayan tracts from Yamuna eastwards to west Bengal, Gujarat, South India and in the Andamans, Madagascar which is used in the treatment of ulcer, cancer, stomach andintestinal diseases and rheumatism. The qualitative phyto-chemical screening showed the presence of phenols, steroids, alkaloids, flavanoids, tannins, carbohydrates, terpenoids, saponins and proteins. The Petroleum ether, Chloroform, Ethyl acetate, Ethanol and Hydro alcohol extracts of the bark of Albizia procera were subjected to In vitro Anti- Inflammatoryactivity by HRBC membrane stabilization method and In vitro antioxidant activity by Lipid Per Oxidation method in various concentrations i.e. 10, 50, 100, 200, 400, 800, 1000 μg/ml. In Anti-Inflammatory activity the effect was represented as follows Ethanol> Ethyl acetate > Hydro alcohol > Chloroform>Petroleum ether. In Lipid per oxidation activity, the effect was represented as follows Ethanol > Hydro alcohol> Ethyl acetate > Chloroform > Petroleum ether Albizia procera exhibits the above activity which can be accredited by phenolic acids present in it.