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Narendra Kumar Reddy K.,Mother Theresa Educational Society Group of Institutions | Hema Pratyusha P.,Mother Theresa Educational Society Group of Institutions
Journal of Chemical and Pharmaceutical Sciences | Year: 2012

A simple, rapid and accurate and stability indicating RP-HPLC method was developed for the determination of valsartan in pharmaceutical dosage forms. An isocratic RP-HPLC was achieved on Waters 2695 using Xterra C18 (150mm x 4.6mm x 5μm) column with the mobile phase consisting of potassium dihydrogen ortho-phosphate, pH adjusted to 3.0 using ortho-phosphoric acid (solvent A), and Acetonitrile (solvent B) in the ratio of 55:45%v/v. The method showed a linear response for concentrations in the range of 10-50 μg/mL using Potassium dihydrogen phosphate (pH 3.0) buffer:Acetonitrile [55:45] as the mobile phase with detection at 286 nm and a flow rate of 0.7 mL min-1 and retention time 7.041 min. The method was statistically validated for accuracy, precision, linearity, robustness, forced degradation and selectivity. The proposed method was validated as per ICH guidelines. The method was found to be suitable for the quality control of valsartan in bulk and pharmaceutical dosage forms as well as the stability-indicating studies. Source


Narendra Kumar Reddy K.,Mother Theresa Educational Society Group of Institutions | Hema Pratyusha P.,Mother Theresa Educational Society Group of Institutions
Journal of Chemical and Pharmaceutical Sciences | Year: 2012

A simple, rapid and accurate and stability indicating RP-HPLC method was developed for the determination of Telmisartan in pharmaceutical dosage forms. An isocratic RP-HPLC was achieved on Waters 2695 using Xterra C18 (150mm x 4.6mm x 5μm) column with the mobile phase consisting of 20 mM Potassium dihydrogen phosphate, pH adjusted to 3.5 using ortho-phosphoric acid (solvent A), and Acetonitrile (solvent B) in the ratio of 40:60% V/V. The method showed a linear response for concentrations in the range of 10-50 μg/mL using Potassium dihydrogen phosphate (pH 3.5) buffer: Acetonitrile [40:60] as the mobile phase with detection at 272 nm and a flow rate of 0.8 mL min-1 and retention time 3.533 min. The method was statistically validated for accuracy, precision, linearity, robustness, forced degradation and selectivity. The proposed method was validated as per ICH guidelines. The method was found to be suitable for the quality control of Telmisartan in bulk and pharmaceutical dosage forms as well as the stability-indicating studies. Source

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