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Bashmakova N.V.,Mother and Child Care Research Institute | Tsyvian P.B.,Russian Academy of Sciences | Chistiakova G.N.,Mother and Child Care Research Institute | Gazieva I.A.,Mother and Child Care Research Institute | And 2 more authors.
Gynecological Endocrinology | Year: 2015

This study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, n = 39) and normally conceived (control group, n = 68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro- anti-angiogenic factors balance and increase in vascular impedance in ART-conceived embryos. © 2015 © 2015 Taylor & Francis. Source


Tsyvian P.B.,Russian Academy of Sciences | Bashmakova N.V.,Mother and Child Care Research Institute | Kovtun O.P.,Ural Federal University | Makarenko L.V.,Mother and Child Care Research Institute | Pestryaeva L.A.,Mother and Child Care Research Institute
Journal of Developmental Origins of Health and Disease | Year: 2015

This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino acid concentrations were evaluated at the time of delivery in 28 normal pregnancies, 46 obese pregnant women with normal birth weight (Ob-AGA group) and 44 obese pregnant women born themselves SGA (Ob-SGA group). Mean birth weight of newborn infants in Ob-SGA group was significantly less than in normal and Ob-AGA groups. Cholesterol and lipoproteins were significantly elevated in obese women (more prominent in Ob-SGA group). Most amino acid concentrations and fetal-maternal amino acid gradients were significantly lower in Ob-SGA group. These data suggest significant changes in placental amino acid transport/synthetic function in obese women who were born themselves SGA. © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015. Source

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