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Medvedeva M.I.,Mendeleev University of Chemical Technology | Tugusheva N.Z.,Moscow Theoretical and Practical Center for Narcology | Alekseeva L.M.,Moscow Theoretical and Practical Center for Narcology | Kalinkina M.A.,Moscow Theoretical and Practical Center for Narcology | And 6 more authors.
Russian Chemical Bulletin | Year: 2010

Amidinohydrazones were prepared by the condensation of 4-arylamino-2-oxo-5- formyl-1,2-dihydropyridine-3-carbonitriles and 4-arylamino-2-oxo-1,2- dihydropyridine-3-carbaldehydes with aminoguanidinium carbonate with the purpose to investigate their biological activity as putative NO donors. The reaction of 5- Ee Cyrillic sign 3-formylpyridones with diguanidinium carbonate was studied. The formation of stable complexes of 4-arylamino-5-formyl-2-oxo-1,2- dihydropyridine-3-carbonitriles with aminoguanidine and guanidine was discovered. Amidinohydrazones obtained possess antiinflammatory, antidiabetic, and antihypertensive activities. © 2010 Springer Science+Business Media, Inc. Source

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