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Kolyadina I.V.,Russian Academy of Medical Sciences | Poddubnaya I.V.,Russian Academy of Medical Sciences | Frank G.A.,Moscow Research Oncological Institute Named After Pa Gertsen | Komov D.V.,Russian Academy of Medical Sciences | And 8 more authors.
Sovremennye Tehnologii v Medicine | Year: 2012

The aim of the investigation is to study prognostic value of tumor receptor status in early breast cancer (I stage). Materials and Methods. There was performed retrospective analysis of case histories of 1036 patients with early breast cancer (T1N0M0-stage), who were treated in N.N. Blokhin Russian Cancer Research Center and the Clinic of Russian Medical Academy for Postgraduate Education from 1985 till 2009. There was studied the prognostic significance of estrogen receptor (ER), progesterone receptor (PR) and HER2, as well as prognostic value of HER2 hyperexpression in early breast cancer both in independent form, and in combination with the receptors of steroid hormones. Results. Based on the combination of receptors there were distinguished immunohistochemical subtypes of breast cancer: luminal A and B, triple-negative cancer and cancer with HER2 overexpressoin. The presence or absence of receptors of steroid hormones ER and PR was stated to have no independent prognostic significance in early breast cancer. HER2 hyperexpression shows no prognostic value in the analysis of overall survival, but it is an unfavourable factor for recurrence free survival both as an independent form, and in combination with the steroid hormone receptors. Source


Kolyadina I.V.,Russian Academy of Medical Sciences | Poddubnaya I.V.,Leiden University | van de Velde C.J.H.,Leiden University | Kuppen P.J.K.,Leiden University | And 14 more authors.
Sovremennye Tehnologii v Medicine | Year: 2012

The aim of the investigation is the study of prognostic significance of age in early breast cancer (T1N0M0-stage) on the basis of large clinical data. Materials and methods. In multi-centre study included archival data of patients with early breast cancer (T1N0M0-stage) who had been treated from 1985 to 2009 in Russia (N.N. Blokhin Russian Cancer Research Center of Russian Academy of Medical Science and Clinic of Russian Medical Academy for Postgraduate Education - 1036 female) and in the Netherlands (Leiden University Medical Center, LUMC - 560 patients). For comparison there were studied the data of Dutch Cancer Database (22 196 patients included into National Archive from 1989 to 2009). Results. Age of patients is an important prognostic factor for early breast cancer: the rate of recurrences is higher in patients <40 years and free-relapse survival is better for patients >50 years. In analyses was found predominance of patients >50 years in the Netherlands for comparing with Russia and also was shown the growth of age of patients with early breast cancer during the twenty years in both countries. Source


Prozorova E.V.,Moscow Research Oncological Institute Named After Pa Gertsen | Kazakevitch V.I.,Moscow Research Oncological Institute Named After Pa Gertsen | Sidorov D.V.,Moscow Research Oncological Institute Named After Pa Gertsen | Mitina L.A.,Moscow Research Oncological Institute Named After Pa Gertsen | Stepanov S.O.,Moscow Research Oncological Institute Named After Pa Gertsen
Sovremennye Tehnologii v Medicine | Year: 2014

Significant advances in preoperative diagnostic techniques have slightly reduced the value of intraoperative ultrasonography (IOUS, sonography) for pancreatic tumor diagnosis. However, tumor extension degree is finally determined during intraoperative revision. IOUS is a technique, which enables to assess a tumor process extension degree and perform minimally invasive surgeries for morphological verification of the changes revealed. The aim of the investigation was to assess the capabilities of intraoperative ultrasound investigation to determine the degree of pancreatic tumor extension. Materials and Methods. 53 patients with morphologically verified diagnosis of pancreatic tumor underwent IOUS. We assessed if the tumor extended beyond the pancreatic capsule involving the surrounding cellular tissue, magistral vessels, and revealed metastases in lymph nodes and liver. If there were N3 (according to JPS, Japan Pancreatic Society) metastases in lymph nodes or in liver, they were needled. Results. 10 patients underwent test laparotomy following IOUS. Laparotomy resulted from: the involvement of the superior mesenteric vein up to the inflows (4 patients), liver metastases (2 patients), peritoneal dissemination (3 patients), liver metastases and peritoneal dissemination (1 patient). IOUS accuracy in determining the tumor extension beyond the pancreatic capsule was 98%. We distinguished two types of surrounding cellular tissue infiltrated by the tumor: focal and diffuse. IOUS sensitivity, specificity and accuracy in vascular invasion determination were 96, 93.3 and 95% respectively. Lymph gland metastases (N3 according to JPS) were detected in 5 patients; the lymph nodes being needled for morphological verification of tumor changes. Liver metastases were found in 3 patients. Paracentesis was performed for morphological verification of a tumor. Conclusion. Intraoperative ultrasonography is a highly informative diagnostic technique used to determine the degree of pancreatic tumor extension. Moreover, IOUS enables to perform morphological verification to detect distant metastases (primarily, in liver and distant lymph nodes) with low complication rate. Source

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