Moscow Research and Clinical Center for Neuropsychiatry
Moscow Research and Clinical Center for Neuropsychiatry
Yakovlev A.A.,Institute of Higher Nervous Activity and Neurophysiology |
Guekht A.B.,Moscow Research and Clinical Center for Neuropsychiatry |
Gulyaeva N.V.,Institute of Higher Nervous Activity and Neurophysiology
Biomeditsinskaia khimiia | Year: 2017
Cortexin, a drug containing hydrolyzed brain peptides, has long been used in clinics, but the mechanisms of its action remain obscure. We have hypothesized that cortexin-related neuroprotection is associated with the ability of the drug to inhibit brain proteases. Cortexin effectively inhibited brain caspase-8, while its effects on caspase-1, -3, -9, cathepsin B and calpain were much less pronounced or absent. In addition, we isolated a peptide fraction from cortexin holding all the inhibitory capacity of the original drug, but with a much more simple composition. Both cortexin and its fraction prevented neuronal damage in a culture model of glutamate-induced cell death. Neuroprotective effect of Cortexin may be mediated by inhibition of the initiator caspase-8 in the brain.Peptidnyĭ preparat korteksin davno ispol'zuetsia v klinike, odnako mekhanizmy deĭstviia étogo preparata ostaiutsia nedostatochno issledovannymi. Éto delaet aktual'nym izuchenie molekuliarnykh mekhanizmov vliianiia korteksina na funktsionirovanie mozga i, prezhde vsego, poisk pervichnykh molekuliarnykh misheneĭ. My predpolozhili, chto neĭroprotektornoe deĭstvie korteksina sviazano s ego sposobnost'iu ingibirovat' proteazy, prinimaiushchie uchastie v gibeli kletok mozga. V rezul'tate provedennykh éksperimentov ustanovleno, chto korteksin sposoben éffektivno ingibirovat' kaspazu-8 mozga. Krome kaspazy-8 byli issledovany drugie proteazy, kaspazy-1, -3 i -9, katepsin V i kal'pain, no oni ingibiruiutsia korteksinom menee éffektivno, libo ne ingibiruiutsia sovsem. Iz korteksina byla vydelena fraktsiia vodorastvorimykh peptidov, obladaiushchaia vsemi ingibiruiushchimi proteazy svoĭstvami iskhodnogo korteksina, no znachitel'no bolee prostaia po sostavu. Kak korteksin, tak i vydelennaia iz nego peptidnaia fraktsiia sposobny v éksperimentakh in vitro predotvrashchat' indutsirovannuiu glutamatom gibel' neĭronov. Takim obrazom, neĭroprotektornoe deĭstvie korteksina mozhet byt' oposredovano priamym ingibirovaniem initsiatornoĭ kaspazy-8 mozga.
PubMed | Niguarda Hospital, University of Strasbourg, Moscow Research and Clinical Center for Neuropsychiatry, Vilnius University and 22 more.
Type: | Journal: Epilepsia | Year: 2017
We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty-six epilepsy centers and members of E-PILEPSY (a European pilot network of reference centers in refractory epilepsy and epilepsy surgery), were asked to report the status of neuropsychological assessment in adults and children via two different surveys. There was a consensus among these centers regarding the role of neuropsychology in the presurgical workup. Strong agreement was found on indications (localization, epileptic dysfunctions, adverse drugs effects, and postoperative monitoring) and the domains to be evaluated (memory, attention, executive functions, language, visuospatial skills, intelligence, depression, anxiety, and quality of life). Although 186 different tests are in use throughout these European centers, a core group of tests reflecting a moderate level of agreement could be discerned. Variability exists with regard to indications, protocols, and paradigms for the assessment of hemispheric language dominance. For the tests in use, little published evidence of clinical validity in epilepsy was provided. Participants in the survey reported a need for improvement concerning the validity of the tests, tools for the assessment of everyday functioning and accelerated forgetting, national norms, and test co-normalization. Based on the present survey, we documented a consensus regarding the indications and principles of neuropsychological testing. Despite the variety of tests in use, the survey indicated that there may be a core set of tests chosen based on experience, as well as on published evidence. By combining these findings with the results of an ongoing systematic literature review, we aim for a battery that can be recommended for the use across epilepsy surgical centers in Europe.
Brainin M.,Danube University Krems |
Tuomilehto J.,Danube University Krems |
Heiss W.-D.,Max Planck Institute for Neurological Research |
Bornstein N.M.,Tel Aviv Sourasky Medical Center |
And 15 more authors.
European Journal of Neurology | Year: 2015
The close relationship between stroke and dementia is an important health issue. Ischaemic stroke can facilitate the onset of vascular dementia as well as aggravate pre-existing cognitive decline. The onset of cognitive decline may become manifest immediately following the onset of ischaemic stroke, but often there is a delay in the development of cognitive decline after a stroke. This delay can be seen as a therapeutic time window allowing interventions to be applied to preserve cognition following stroke. Both neurodegenerative and vascular mechanisms are activated and probably result in overlapping processes within the neurovascular unit. This review focuses on the incidence and prevalence of cognitive decline following stroke, predisposing stroke aetiologies, pre-stroke decline, imaging factors and biomarkers. Outcomes are discussed in relation to timing of assessment and neuropsychological tests used for evaluation of cognitive decline in ischaemic stroke patients. Including such tests in routine evaluations of stroke patients after some weeks or months is recommended. Finally, an outlook on ongoing and planned intervention trials is added and some recommendations for future research are proposed. © 2014 EAN.
Bryukhin A.E.,Peoples' Friendship University of Russia |
Sologub M.B.,Moscow Research and Clinical Center for Neuropsychiatry |
Abdraeva N.K.,Peoples' Friendship University of Russia
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015
A case of comorbid anorexia nervosa and kleptomania is reported in a female patient aged 31 years old. Personality pathology and kleptomanic behavior developed since childhood together with dysmorphophobia related to the congenital chest defect. Later on, the distinct association between the severity of dysmorphophobia, affective disorder and appearances of pathological drives was identified. The patient received several ICD-10 diagnoses (F61.0, F50.0, F62.3, F33.1). The patient’s condition was improved after pharmacotherapy in the combination with psychotherapy. © 2015, Media Sphera. All rights reserved.
Guekht A.,Russian National Research Medical University |
Mizinova M.,Russian National Research Medical University |
Kaimovsky I.,Russian National Research Medical University |
Danilenko O.,Moscow Research and Clinical Center for Neuropsychiatry |
And 2 more authors.
Epilepsy and Behavior | Year: 2016
Objective The objective of this study was to investigate prospectively the direct costs of epilepsy in Russia, taking a patient perspective and a bottom-up approach. Methods The study was conducted in adolescents and adults with epilepsy seen in the ambulatory services of a city hospital in Moscow. Patients were assigned to different prognostic categories: newly diagnosed epilepsy; epilepsy in remission for 2 + years; epilepsy in remission for < 2 years or with occasional seizures; active, nondrug-resistant epilepsy; drug-resistant epilepsy; and drug-resistant epilepsy in surgical candidates. Patients were followed prospectively for 12 months. Demographic and clinical features at admission were collected and correlated with costs. Cost estimates were based on the Russian National Health Service perspective and its implementation in Moscow. Cost items included drugs and laboratory/instrumental tests. The costs per patient were calculated for the entire sample and for each prognostic category separately. Univariate and multivariate analyses were performed. Results Included were 738 patients (393 men, 345 women aged 14–85 years). The median annual cost/patient was €955 (IQR 521–2134; range 51–10,904). The median cost of drugs was €643 (IQR 288–1866; range 0–9960), and the median cost of laboratory/instrumental testing was €202 (IQR 160–270; range 20–1217). Mean costs varied across prognostic categories ranging from €782 in newly diagnosed patients to €3777 in patients with drug-resistant epilepsy. Mean (SD) hospital costs ranged from €646.7 (109.0) in patients with occasional seizures to €950.0 (28.3) in surgical candidates. Independent predictors of total costs were younger age at diagnosis, disability status, generalized seizures, multiple seizure types, seizure severity, and etiology. Significance The cost of epilepsy in Moscow varies significantly depending on disease characteristics and response to drug treatment. © 2016 Elsevier Inc.