Moscow Regional Research Institute of Obstetrics and Gynecology

Moscow, Russia

Moscow Regional Research Institute of Obstetrics and Gynecology

Moscow, Russia
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Balan V.E.,Moscow Regional Research Institute of Obstetrics and Gynecology | Tikhomirova E.V.,Moscow Regional Research Institute of Obstetrics and Gynecology
Akusherstvo i Ginekologiya (Russian Federation) | Year: 2017

Objective. To determine the efficacy, safety, and control cycle of a low-dose monophasic combined oral contraceptive pill containing 20 μg ethinyl estradiol and 3 mg drospirenone, which is taken daily for 24 days, followed by a four-day hormone-free interval. Subjects and methods. The investigation covered 40 women. In the first 2 months of taking the birth-control pill, only one (2.5%) woman was observed to have irregular intermenstrual bleeding that was not seen in the third cycle of its use. Results. A dimia pill containing 20 μg of ethinyl estradiol plus 3 mg drospirenone in a 24+4 regimen has an excellent tolerability and high values of safety and acceptability. Most (92.5%) women reported that they would like to continue to use the test drug for the treatment of menstrual irregularities and for contraception. Conclusion. The combination of 20 μg ethinyl estradiol and 3 mg drospirenone (dimia) taken daily for 24 days, followed by a four-day hormone-free interval (a 24+4 regimen) provides effective contraception and good cycle control. © 2017, Bionika Media Ltd. All Rights Reserved.


Balan V.E.,Moscow Regional Research Institute of Obstetrics and Gynecology | Ovchinnikova V.V.,Moscow Regional Research Institute of Obstetrics and Gynecology | Tikhomirova E.V.,Moscow Regional Research Institute of Obstetrics and Gynecology
Akusherstvo i Ginekologiya (Russian Federation) | Year: 2017

Objective. To investigate the efficiency and antirecurrent activity of adjuvant therapy with Multi-Gyn actigel for bacterial vaginosis (BV) in reproductive-aged women. Subjects and methods. The investigation covered 50 female patients, whose mean age was 18 to 45 years (29.6±4.5 years), with a clinical diagnosis of BV confirmed by real-time polymerase chain reaction (Femoflor-16 real-time PCR). The patients were randomized into two equal groups of 25 subjects in each. Group 1 received one-dose vaginal clindamycin cream overnight for 10 days and, as therapy stage 2, the actigel 2 mg twice daily for 10 days. Group 2 used one-dose vaginal clindamycin cream overnight for 10 days and, as therapy stage 2, a drug containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 for 14 days. Results. The therapeutic effectiveness was 92% (n = 46) in both groups. However, the more sustained remission rates were 88% (n = 22) in the group of patients receiving adjuvant therapy with Multi-Gyn actigel and 64% (n = 16) in the comparison group (p < 0.5). Conclusion. Long-term adjuvant Multi-Gyn actigel therapy in conjunction with etiotropic therapy was associated with a longer recurrent BV-free interval. Addition of Multi-Gyn actigel considerably improved treatment results. Drugs that contain probiotic Lactobacilli are also effective in the combination therapy of BV; however, their efficacy is based on their longer use. © 2017, Bionika Media Ltd. All right reserved.


Krasnopolskaya K.V.,Moscow Regional Research Institute of Obstetrics and Gynecology | Nazarenko T.A.,Moscow Regional Research Institute of Obstetrics and Gynecology | Sesina N.I.,Family embryology laboratory of the International Clinic | Aleksandrova V.R.,Moscow Regional Research Institute of Obstetrics and Gynecology
Akusherstvo i Ginekologiya (Russian Federation) | Year: 2017

Objective. To analyze the laboratory and clinical outcomes of IVF-DO programs using embryos from vitrified donor oocytes and to compare them with the results of those with native and thawed embryos derived from native donor oocytes. Material and methods. The results of IVF-DO programs using vitrified oocytes (29 oocyte thaw cycles), native embryos (115 embryo transfer (ET) cycles), and thawed embryos derived from native oocytes (56 ET cycles) were compared. The survival and fertilization rates of thawed vitrified oocytes were clarified in assessing the results. When the clinical outcomes of the IVF-DO programs compared were assessed, the rates of ET discontinuation, pregnancy per ET, implantation, multiple pregnancy, and early reproductive losses were analyzed. Results. The survival and fertilization rates of vitrified oocytes were ascertained to be 88.7 and 67%, respectively. The clinical outcomes of IVF-DO using the embryos derived from vitrified oocytes were substantially inferior to those with native or thawed embryos obtained from native oocytes in terms of all the most important indicators. Treatment results in view of pregnancy rates in the IVF-DO programs with vitrified oocytes can be improved only by increasing the number of transferred embryos to three; however, there is a dramatic increase in multiple pregnancy risk that is much greater than in the alternative IVF-DO programs with native or thawed embryos derived from freshly isolated oocytes. Conclusion. In all situations when the use of donor oocytes is required to overcome infertility, it is advisable to give priority to IVF-DO programs using just native or thawed embryos obtained from native oocytes. © 2017, Bionika Media Ltd. All Rights Reserved.


Dedov I.I.,Endocrinology Research Center | Krasnopol'skii V.I.,Moscow Regional Research Institute of Obstetrics and Gynecology
Diabetes Mellitus | Year: 2012

Current document presents a coherent viewpoint of Russian Association of Endocrinologists and Russian Association of Obstetricians and Gynaecologists on diagnostic criteria of gestational diabetes mellitus (GDM) and other glycemic disorders during gestation. Current approach is based on analysis of high-profile multinational study HAPO (Hyperglycemia and Adverse Pregnancy Outcomes Study), which included more than 23 000 pregnant women. This project was repeatedly reviewed on workgroup sessions and presented orally on 6th Russian Congress of Endocrinology with international participation, as well as Russian interdisciplinary educational congress "Gestational Complications and Premature Delivery".


PubMed | Nasonova Research Institute of Rheumatology and Moscow Regional Research Institute of Obstetrics and Gynecology
Type: Journal Article | Journal: Biomeditsinskaia khimiia | Year: 2016

Previously, it was found that blood plasma extracellular DNA (ecDNA) of patients with rheumatoid arthritis (RA) is enriched with CpG-rich genomic DNA fragments, which contain TLR9 ligands (Veiko et al., 2006). In this study we have demonstrated that ecDNA of a RA patient and model fragments added to a cultivation medium of peripheral blood mononuclear cells (PBMC) of healthy donors stimulate expression of genes for the TLR9-MyD88-NF-kB signaling pathway; this leads to a significant increase in concentrations of the proinflammatory cytokines IL-6 and TNF-a in the cultivation medium. Human genomic DNA non-enriched with the CpG sequences did not stimulate IL-6 and TNF-a synthesis in PBMC. A scheme explaining the potential role ecDNA in the induction and maintenance of increased levels of the proinflammatory cytokines under conditions damaging the human cells has been proposed.


PubMed | Belgorod State University and Moscow Regional Research Institute of Obstetrics and Gynecology
Type: Journal Article | Journal: Arkhiv patologii | Year: 2016

to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations.Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated.Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy. Abnormal placental immaturity developed; the number of terminal villi decreased; sclerosis occurred. The magnitude of changes showed up to a greater extent in the myometrium, umbilical cord, and placenta of women, whose pregnancy occurred with DTG, and in patients with disease recurrence. In preeclampsia, plethora, stasis, and thrombosis were added to circulatory disorders.Not only the diagnosis itself of DTG, but also the type of its course and the pattern of obstetric disease, primarily preeclampsia, affect the state of structural components of the uteroplacental unit.


PubMed | Moscow Regional Research Institute of Obstetrics and Gynecology and Medical University of Vienna
Type: Journal Article | Journal: International urogynecology journal | Year: 2016

We hypothesized that knowledge of pelvic organ prolapse (POP) and patient information-seeking preferences are the same in the two capital cities.First-visit patients were recruited at tertiary referral urogynaecological units in Vienna (137) and in Moscow (112). A 16-item scale was used to assess the patient knowledge of POP. The 16 items comprised 12 specific items taken from the Prolapse and Incontinence Knowledge Questionnaire (PIKQ) and four added items. The preliminary psychometric assessment of the knowledge scales in German and Russian was performed in the Vienna and in Moscow centres.The mean total knowledge scores in patients in Vienna and in Moscow were not significantly different: 9.73.5 vs. 9.82.9 (p=0.92). Patients in Vienna were more likely to answer questions about the pathogenesis of POP correctly. Patients in Moscow achieved higher scores for items assessing knowledge about the diagnosis of POP. Women in the two study groups equally preferred to obtain information about POP from medical specialists (72% and 82%; p=0.61), followed by friends and family for patients in Vienna (25%), and the internet for patients in Moscow (23%). Patients in Vienna were more likely to use printed sources (18% and 7%; p=0.001) than patients in Moscow.The mean level of knowledge of POP did not differ between patients in Vienna and patients in Moscow. The differences between the specific knowledge domains might be explained by different cultural preferences for seeking health information and by the range of the information sources available.


Popov A.,Moscow Regional Research Institute of Obstetrics and Gynecology | Gumina D.,Moscow Regional Research Institute of Obstetrics and Gynecology | Mironenko K.,Moscow Regional Research Institute of Obstetrics and Gynecology | Slobodyanyuk B.,Moscow Regional Research Institute of Obstetrics and Gynecology | And 4 more authors.
International Urogynecology Journal and Pelvic Floor Dysfunction | Year: 2016

Surgical creation of a neovagina using the sigmoid was one of the main techniques used in patients with Mayer–Rokinatsky–Küster–Hauser syndrome. Nowadays, this surgery is not common as a result of the high frequency of complications and adverse outcomes, one of which is sigmoid neovagina prolapse. There are no standards of treatment because of the rarity of these clinical events; therefore, any medical case is important. We present a case report of a 72-year-old patient with prolapse of the sigmoid stump. Perscrutation of this example allows us to conclude that laparoscopic sacrocolpopexy is the optimal operation for patients with apical prolapse and a history of sigmoidal colpopoiesis owing to its high level of safety and excellent outcomes. © 2015, The International Urogynecological Association.


Burumkulova F.F.,Moscow Regional Research Institute of Obstetrics and Gynecology | Petrukhin V.A.,Moscow Regional Research Institute of Obstetrics and Gynecology
Terapevticheskii Arkhiv | Year: 2014

Gestational diabetes mellitus (GDM) is hyperglycemia that is first detected during pregnancy and does not meet the criteria for manifest diabetes. The incidence of GDM worldwide varies from 1 to 14% and that in Russia is as high as 4%. Hyperglycemia during pregnancy is associated with the development of preeclampsia, the birth of a big baby, emergency cesarean section, birth trauma, and neonatal hypoglycemia. The fact that there is no well-organized screening for GDM in our country leads to that the diagnosis of this condition is delayed for 4-20 weeks in 50-60% of cases. The risk group distribution of pregnant women leads to the diagnosis of GDM only in 50% of cases. At the same time, pregnancy is accompanied by physiological insulin resistance so the latter itself is a clinically important risk factor for carbohydrate metabolic disturbances. The Hyperglycemia and Adverse Pregnancy Outcomes (HYPO) study has indicated that the previously used diagnostic criteria for GDM require reconsideration. There is a need for uniform standards for the diagnosis and treatment of carbohydrate metabolic disturbances during pregnancy. The concepts «diabetes mellitus (DM)» and «manifest (new-onset DM during pregnancy» and directly «GDM» require clear clinical and laboratory definitions. Furthermore, GDM is a risk factor for obesity, type 2 DM and cardiovascular diseases in the mother and her offspring in future.


PubMed | Moscow Regional Research Institute of Obstetrics and Gynecology
Type: Case Reports | Journal: International urogynecology journal | Year: 2016

Surgical creation of a neovagina using the sigmoid was one of the main techniques used in patients with Mayer-Rokinatsky-Kster-Hauser syndrome. Nowadays, this surgery is not common as a result of the high frequency of complications and adverse outcomes, one of which is sigmoid neovagina prolapse. There are no standards of treatment because of the rarity of these clinical events; therefore, any medical case is important. We present a case report of a 72-year-old patient with prolapse of the sigmoid stump. Perscrutation of this example allows us to conclude that laparoscopic sacrocolpopexy is the optimal operation for patients with apical prolapse and a history of sigmoidal colpopoiesis owing to its high level of safety and excellent outcomes.

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