Moscow Regional Research Institute of Obstetrics and Gynecology

Moscow, Russia

Moscow Regional Research Institute of Obstetrics and Gynecology

Moscow, Russia

Time filter

Source Type

Barinova I.V.,Moscow Regional Research Institute of Obstetrics and Gynecology
Arkhiv Patologii | Year: 2012

Massive subchorial thrombosis (MSCT) is a placental abnormality, the etiology and pathogenesis of which remain inadequately studied. MSCT is characterized by a clinical symptom complex comprising marked intrauterine growth retardation, oligohydramnios, and fetal distress due to placental circulatory problems. Perinatal outcomes are appreciably determined by the term of pregnancy, the degree of placental insufficiency, and neonatal status. Prolonged MSCT makes it possible to diagnose this pathology by echographic and magnetic resonance imaging studies and to attempt to treat placental dysfunction through tocolytic therapy and correction of oligohydramnios, to prolong pregnancy, and to have a viable newborn infant. The clinical and morphological diagnosis of MSCT calls for its differential diagnosis with other focal placental lesions, such as subamniotic, intraplacental, and retroplacental hematomas, cytotrophoblastic cyst, umbilical cord cysts, and chorangioma.


Speranskii A.I.,Russian Academy of Medical Sciences | Kalashnikova E.A.,Moscow Regional Research Institute of Obstetrics and Gynecology
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | Year: 2015

Previously, it was found that blood plasma extracellular DNA (ecDNA) of patients with rheumatoid arthritis (RA) is enriched with CpG-rich genomic DNA fragments, which contain TLR9 ligands (Veiko et al., 2006). In this study we have demonstrated that ecDNA of a RA patient and model fragments added to a cultivation medium of peripheral blood mononuclear cells (PBMC) of healthy donors stimulate expression of genes for the TLR9-MyD88-NFkB-signaling pathway; this leads to a significant increase in concentrations of the proinflammatory cytokines IL-6 and TNFα in the cultivation medium. Human genomic DNA non-enriched with the CpG sequences did not stimulate IL-6 and TNFα synthesis in PBMC. A scheme explaining the potential role ecDNA in the induction and maintenance of increased levels of the proinflammatory cytokines under conditions damaging the human cells has been proposed. © 2015, Pleiades Publishing, Ltd.


Dedov I.I.,Endocrinology Research Center | Krasnopol'skii V.I.,Moscow Regional Research Institute of Obstetrics and Gynecology
Diabetes Mellitus | Year: 2012

Current document presents a coherent viewpoint of Russian Association of Endocrinologists and Russian Association of Obstetricians and Gynaecologists on diagnostic criteria of gestational diabetes mellitus (GDM) and other glycemic disorders during gestation. Current approach is based on analysis of high-profile multinational study HAPO (Hyperglycemia and Adverse Pregnancy Outcomes Study), which included more than 23 000 pregnant women. This project was repeatedly reviewed on workgroup sessions and presented orally on 6th Russian Congress of Endocrinology with international participation, as well as Russian interdisciplinary educational congress "Gestational Complications and Premature Delivery".


PubMed | Nasonova Research Institute of Rheumatology and Moscow Regional Research Institute of Obstetrics and Gynecology
Type: Journal Article | Journal: Biomeditsinskaia khimiia | Year: 2016

Previously, it was found that blood plasma extracellular DNA (ecDNA) of patients with rheumatoid arthritis (RA) is enriched with CpG-rich genomic DNA fragments, which contain TLR9 ligands (Veiko et al., 2006). In this study we have demonstrated that ecDNA of a RA patient and model fragments added to a cultivation medium of peripheral blood mononuclear cells (PBMC) of healthy donors stimulate expression of genes for the TLR9-MyD88-NF-kB signaling pathway; this leads to a significant increase in concentrations of the proinflammatory cytokines IL-6 and TNF-a in the cultivation medium. Human genomic DNA non-enriched with the CpG sequences did not stimulate IL-6 and TNF-a synthesis in PBMC. A scheme explaining the potential role ecDNA in the induction and maintenance of increased levels of the proinflammatory cytokines under conditions damaging the human cells has been proposed.


Pavlova T.V.,Belgorod State University | Malyutina E.S.,Belgorod State University | Petrukhin V.A.,Moscow Regional Research Institute of Obstetrics and Gynecology
Arkhiv Patologii | Year: 2015

Objective: to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations. Subjects and methods: Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated. Results: Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy. Abnormal placental immaturity developed; the number of terminal villi decreased; sclerosis occurred. The magnitude of changes showed up to a greater extent in the myometrium, umbilical cord, and placenta of women, whose pregnancy occurred with DTG, and in patients with disease recurrence. In preeclampsia, plethora, stasis, and thrombosis were added to circulatory disorders. Conclusion: Not only the diagnosis itself of DTG, but also the type of its course and the pattern of obstetric disease, primarily preeclampsia, affect the state of structural components of the uteroplacental unit.


PubMed | Belgorod State University and Moscow Regional Research Institute of Obstetrics and Gynecology
Type: Journal Article | Journal: Arkhiv patologii | Year: 2016

to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations.Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated.Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy. Abnormal placental immaturity developed; the number of terminal villi decreased; sclerosis occurred. The magnitude of changes showed up to a greater extent in the myometrium, umbilical cord, and placenta of women, whose pregnancy occurred with DTG, and in patients with disease recurrence. In preeclampsia, plethora, stasis, and thrombosis were added to circulatory disorders.Not only the diagnosis itself of DTG, but also the type of its course and the pattern of obstetric disease, primarily preeclampsia, affect the state of structural components of the uteroplacental unit.


PubMed | Moscow Regional Research Institute of Obstetrics and Gynecology and Medical University of Vienna
Type: Journal Article | Journal: International urogynecology journal | Year: 2016

We hypothesized that knowledge of pelvic organ prolapse (POP) and patient information-seeking preferences are the same in the two capital cities.First-visit patients were recruited at tertiary referral urogynaecological units in Vienna (137) and in Moscow (112). A 16-item scale was used to assess the patient knowledge of POP. The 16 items comprised 12 specific items taken from the Prolapse and Incontinence Knowledge Questionnaire (PIKQ) and four added items. The preliminary psychometric assessment of the knowledge scales in German and Russian was performed in the Vienna and in Moscow centres.The mean total knowledge scores in patients in Vienna and in Moscow were not significantly different: 9.73.5 vs. 9.82.9 (p=0.92). Patients in Vienna were more likely to answer questions about the pathogenesis of POP correctly. Patients in Moscow achieved higher scores for items assessing knowledge about the diagnosis of POP. Women in the two study groups equally preferred to obtain information about POP from medical specialists (72% and 82%; p=0.61), followed by friends and family for patients in Vienna (25%), and the internet for patients in Moscow (23%). Patients in Vienna were more likely to use printed sources (18% and 7%; p=0.001) than patients in Moscow.The mean level of knowledge of POP did not differ between patients in Vienna and patients in Moscow. The differences between the specific knowledge domains might be explained by different cultural preferences for seeking health information and by the range of the information sources available.


Popov A.,Moscow Regional Research Institute of Obstetrics and Gynecology | Gumina D.,Moscow Regional Research Institute of Obstetrics and Gynecology | Mironenko K.,Moscow Regional Research Institute of Obstetrics and Gynecology | Slobodyanyuk B.,Moscow Regional Research Institute of Obstetrics and Gynecology | And 4 more authors.
International Urogynecology Journal and Pelvic Floor Dysfunction | Year: 2016

Surgical creation of a neovagina using the sigmoid was one of the main techniques used in patients with Mayer–Rokinatsky–Küster–Hauser syndrome. Nowadays, this surgery is not common as a result of the high frequency of complications and adverse outcomes, one of which is sigmoid neovagina prolapse. There are no standards of treatment because of the rarity of these clinical events; therefore, any medical case is important. We present a case report of a 72-year-old patient with prolapse of the sigmoid stump. Perscrutation of this example allows us to conclude that laparoscopic sacrocolpopexy is the optimal operation for patients with apical prolapse and a history of sigmoidal colpopoiesis owing to its high level of safety and excellent outcomes. © 2015, The International Urogynecological Association.


Burumkulova F.F.,Moscow Regional Research Institute of Obstetrics and Gynecology | Petrukhin V.A.,Moscow Regional Research Institute of Obstetrics and Gynecology
Terapevticheskii Arkhiv | Year: 2014

Gestational diabetes mellitus (GDM) is hyperglycemia that is first detected during pregnancy and does not meet the criteria for manifest diabetes. The incidence of GDM worldwide varies from 1 to 14% and that in Russia is as high as 4%. Hyperglycemia during pregnancy is associated with the development of preeclampsia, the birth of a big baby, emergency cesarean section, birth trauma, and neonatal hypoglycemia. The fact that there is no well-organized screening for GDM in our country leads to that the diagnosis of this condition is delayed for 4-20 weeks in 50-60% of cases. The risk group distribution of pregnant women leads to the diagnosis of GDM only in 50% of cases. At the same time, pregnancy is accompanied by physiological insulin resistance so the latter itself is a clinically important risk factor for carbohydrate metabolic disturbances. The Hyperglycemia and Adverse Pregnancy Outcomes (HYPO) study has indicated that the previously used diagnostic criteria for GDM require reconsideration. There is a need for uniform standards for the diagnosis and treatment of carbohydrate metabolic disturbances during pregnancy. The concepts «diabetes mellitus (DM)» and «manifest (new-onset DM during pregnancy» and directly «GDM» require clear clinical and laboratory definitions. Furthermore, GDM is a risk factor for obesity, type 2 DM and cardiovascular diseases in the mother and her offspring in future.


PubMed | Moscow Regional Research Institute of Obstetrics and Gynecology
Type: Case Reports | Journal: International urogynecology journal | Year: 2016

Surgical creation of a neovagina using the sigmoid was one of the main techniques used in patients with Mayer-Rokinatsky-Kster-Hauser syndrome. Nowadays, this surgery is not common as a result of the high frequency of complications and adverse outcomes, one of which is sigmoid neovagina prolapse. There are no standards of treatment because of the rarity of these clinical events; therefore, any medical case is important. We present a case report of a 72-year-old patient with prolapse of the sigmoid stump. Perscrutation of this example allows us to conclude that laparoscopic sacrocolpopexy is the optimal operation for patients with apical prolapse and a history of sigmoidal colpopoiesis owing to its high level of safety and excellent outcomes.

Loading Moscow Regional Research Institute of Obstetrics and Gynecology collaborators
Loading Moscow Regional Research Institute of Obstetrics and Gynecology collaborators