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Barinova I.V.,Moscow Regional Research Institute of Obstetrics and Gynecology
Arkhiv Patologii | Year: 2012

Massive subchorial thrombosis (MSCT) is a placental abnormality, the etiology and pathogenesis of which remain inadequately studied. MSCT is characterized by a clinical symptom complex comprising marked intrauterine growth retardation, oligohydramnios, and fetal distress due to placental circulatory problems. Perinatal outcomes are appreciably determined by the term of pregnancy, the degree of placental insufficiency, and neonatal status. Prolonged MSCT makes it possible to diagnose this pathology by echographic and magnetic resonance imaging studies and to attempt to treat placental dysfunction through tocolytic therapy and correction of oligohydramnios, to prolong pregnancy, and to have a viable newborn infant. The clinical and morphological diagnosis of MSCT calls for its differential diagnosis with other focal placental lesions, such as subamniotic, intraplacental, and retroplacental hematomas, cytotrophoblastic cyst, umbilical cord cysts, and chorangioma. Source

Pavlova T.V.,Belgorod State University | Malyutina E.S.,Belgorod State University | Petrukhin V.A.,Moscow Regional Research Institute of Obstetrics and Gynecology | Nesterov A.V.,Belgorod State University
Arkhiv Patologii | Year: 2012

In maternal thyroid diseases, the placenta shows an increase in complications during pregnancy. There are signs of lesions as alterations, focal sclerosis, and fibrinoid necrosis. There is also a circulatory disorder as plethora and thrombosis. Progression in these changes correlates with the cases of miscarriage and other pathology in the obstetric history. The concurrence of obstetric and endocrine diseases increases the risk of pregnancy, labor, and delivery complications in different maternal thyroid diseases. Source

Pavlova T.V.,Belgorod State University | Malyutina E.S.,Belgorod State University | Petrukhin V.A.,Moscow Regional Research Institute of Obstetrics and Gynecology
Arkhiv Patologii | Year: 2012

Uteroplacental relationships were studied in women with and without hypothyroidism, by applying electron, atomic force, and scanning electron microscopies, which enables one to gain more insight into morphometric characteristics. Moreover, not only fixed, but also native materials were used, which brings the studies to a live object and opens up new avenues for rapid diagnosis. The use of gross and trace analysis allows the biochemical parameters of the structure of uterine and placental tissues to be studied for an additional diagnosis and development of treatment options. Source

Speranskii A.I.,Russian Academy of Medical Sciences | Kalashnikova E.A.,Moscow Regional Research Institute of Obstetrics and Gynecology
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | Year: 2015

Previously, it was found that blood plasma extracellular DNA (ecDNA) of patients with rheumatoid arthritis (RA) is enriched with CpG-rich genomic DNA fragments, which contain TLR9 ligands (Veiko et al., 2006). In this study we have demonstrated that ecDNA of a RA patient and model fragments added to a cultivation medium of peripheral blood mononuclear cells (PBMC) of healthy donors stimulate expression of genes for the TLR9-MyD88-NFkB-signaling pathway; this leads to a significant increase in concentrations of the proinflammatory cytokines IL-6 and TNFα in the cultivation medium. Human genomic DNA non-enriched with the CpG sequences did not stimulate IL-6 and TNFα synthesis in PBMC. A scheme explaining the potential role ecDNA in the induction and maintenance of increased levels of the proinflammatory cytokines under conditions damaging the human cells has been proposed. © 2015, Pleiades Publishing, Ltd. Source

Dedov I.I.,Endocrinology Research Center | Krasnopol'skiy V.I.,Moscow Regional Research Institute of Obstetrics and Gynecology
Diabetes Mellitus | Year: 2012

Current document presents the expert consensus of Russian Association of Endocrinologists and Russian Society of Obstetrician-Gynecologists on diagnostic criteria of gestational diabetes and other glycemic disorders of pregnancy. The consensus is based on analysis of HAPO (Hyperglycemia and Adverse Pregnancy Outcomes Study)-a major multinational study, that included more than 23000 patients. Project of current consensus was repeatedly discussed during meetings of the research group and publicly addressed at 6th Pan-Russian Congress of Endocrinology with international participation «Modern Endocrine Technologies», as well as Pan-Russian Educational Interscience Conference «Complicated Pregnancy and Preterm Birth». Source

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