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Sirak S.V.,Stavropol State Medical University | Shchetinin E.V.,Stavropol State Medical University | Grigoryantz L.A.,Moscow Regional Research Clinical Institute | Parazyan L.A.,Stavropol State Medical University | And 6 more authors.
Medical News of North Caucasus | Year: 2015

The article presents the results of the use of the developed tissue-engineering design in regenerative cell therapy of the pulp of the autotransplanted teeth of a sheep in vivo. Histochemical method for monitoring of vital functions of mesenchymal cells after autologous transplantation of teeth showed that the cells retain the ability to produce factors that accelerate the regeneration of dental pulp and periodontal tissues, which is confirmed by the reduction of the period of cell infiltration timing, acceleration of the rate of proliferation and neoangiogenesis of the pulp vasculature.

Burisch J.,Copenhagen University | Cukovic-Cavka S.,University of Zagreb | Kaimakliotis I.,Private Practice | Shonova O.,Hospital Ceske Budejovice | And 20 more authors.
Journal of Crohn's and Colitis | Year: 2011

Background: The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration. Aim: To construct and validate a web-based inception cohort database available in both English and Russian language. Method: The EpiCom database has been constructed in collaboration with all 34 participating centers. The database was translated into Russian using forward translation, patient questionnaires were translated by simplified forward-backward translation. Data insertion implies fulfillment of international diagnostic criteria, disease activity, medical therapy, quality of life, work productivity and activity impairment, outcome of pregnancy, surgery, cancer and death. Data is secured by the WinLog3 System, developed in cooperation with the Danish Data Protection Agency. Validation of the database has been performed in two consecutive rounds, each followed by corrections in accordance with comments. Results: The EpiCom database fulfills the requirements of the participating countries' local data security agencies by being stored at a single location. The database was found overall to be "good" or "very good" by 81% of the participants after the second validation round and the general applicability of the database was evaluated as "good" or "very good" by 77%. In the inclusion period January 1st -December 31st 2010 1336 IBD patients have been included in the database. Conclusion: A user-friendly, tailor-made and secure web-based inception cohort database has been successfully constructed, facilitating remote data input. The incidence of IBD in 23 European countries can be found at www.epicom-ecco.eu. © 2011 European Crohn's and Colitis Organisation.

Starostina E.G.,Moscow Regional Research Clinical Institute | Moshnyaga E.N.,Moscow Regional Research Clinical Institute
Diabetes Mellitus | Year: 2013

Aim: To assess the prevalence of fear of hypoglycemia, its clinical features and influence on diabetes compensation. Materials and Methods: A cross-sectional study was conducted with 200 sequentially enrolled participants with type 2 diabetes mellitus (T2DM; n=139) and type 1 diabetes mellitus (T1DM; n=61). Patients were screened for psychiatric disorders with appropriate inventory and examined by a psychiatrist. Subjects identified as those with fear of hypoglycemia (n=12) formed the study group, while control group was assembled of individuals without phobic signs, matched for gender, age, type and duration of diabetes and concomitant psychiatric disorders. Results: Prevalence of fear of hypoglycemia was estimated at 6%, being consistently higher in patients with T1DM (16.1%) vs. T2DM (1%; p=0.0002). Fear of hypoglycemia was associated with higher median HbA1c (9.4% [8.6 ; 9.9] vs. 8.2% [6.8 ; 9.3], p<0.05). These findings are in agreement with considerably higher prevalence of proliferative retinopathy (33%) observed in study group (0% in control group, p<0.05). Phobic patients with T1DM had higher occurrence of ketoacidosis (41.7% of subjects, 7 cases) than control subjects (16.6% of subjects, 2 cases). Similar trend was observed for severe hypoglycemic events. There was no significant difference between the groups in sensitivity to hypoglycemia, cognitive functions, educational level or social status. Patients with fear of hypogly-cemia tend to regard hypoglycemia as primary, highly hazardous challenge of diabetes mellitus and perceive its symptoms as «extremely unpleasant». However, in this study phobic patients maintained the same level of self-monitoring as their control counterparts and demonstrated comparable knowledge of the causes of hypoglycemia. None of the participants reported a habit of carrying carbohydrates for hypoglycemia management. Conclusion: Fear of hypoglycemia is highly prevalent among patients with T1DM and is often associated with poor diabetes compensation, glycemic instability and higher risk for diabetic macroangiopathy. Attitude to hypoglycemia in such patients resembles idée fixe phenomenon with pathologically accentuated somatic perception of hypoglycemia and exaggeration of associated health hazards. Patients with fear of hypoglycemia tend to develop avoidance behaviour regarding diabetes mellitus that, combined with lower compliance for prevention of hypoglycemia, worsens clinical prognosis.

Dreval' A.V.,Moscow Regional Research Clinical Institute | Misnikova I.V.,Moscow Regional Research Clinical Institute | Gubkina V.A.,Moscow Regional Research Clinical Institute | Agal'tsov M.V.,State Research Center for Preventive Medicine | Fedorova S.I.,Moscow Regional Research Clinical Institute
Diabetes Mellitus | Year: 2013

Aims: To assess the risk for sleep apnea in patients with various types of glycemic disorders by means of Epworth Sleepiness Scale and Sleep Apnea Screening Questionnaire. Materials and Methods: We examined 744 residents of Mozhaisk Region, that were considered to have high risk for development of type 2 diabetes mellitus (T2DM), as estimated by FINDRISK Questionnaire. Patients, who scored 12+ were cleared for participation in this study. Combined score from Epworth Sleepiness Scale and Sleep Apnea Screening Questionnaire was applied for diagnosis of sleep apnea, supplemented with specific questions about snoring and episodes of apnea. Glycemic disorders were diagnosed with standard glucose tolerance test. Results: 42.7% of examined patients (n=318) were diagnosed with various types of glucose disorders. Prevalence of abdominal obesity (according to waist circumference measurement) comprised 59.3% in male patients and 54.1% in females. We observed positive correlation between body mass index (BMI) and snoring - 0.3 (p=0.0001), BMI and apnea - 0.2 (p=0.0001), BMI and daytime sleepiness - 0.1 (p=0.007); we also observed direct correlation between age and snoring - 0.2 (p=0.0001), as well as age and sleep apnea - 0.1 (p=0.028). Risk for sleep apnea was found to be 4.7 times higher in patients with arterial hypertension. After adjustment for age risk of apnea remained 2.8 times higher in patients with T2DM, 1.9 times higher in subjects with impaired glucose tolerance and 1.6 times higher in subjects with impaired fasting glycaemia. Relative risk for snoring in patients with various types of glycemic disorders was 1.1-1.2 against normoglycemic controls. We estimated that all types of glycemic disorders increase risk for apnea 1.2-1.6 times. Conclusion: Glycemic disorders, body weight excess, obesity and arterial hypertension are risk factors for snoring and sleep apnea. Corresponding patient categories should be screened for sleep apnea by questionnaire survey to identify those in need of further complex examination and treatment.

Burisch J.,Copenhagen University | Weimers P.,Copenhagen University | Pedersen N.,Copenhagen University | Cukovic-Cavka S.,University of Zagreb | And 53 more authors.
Journal of Crohn's and Colitis | Year: 2014

Background & Aims: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe. Methods: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1. million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up. Results: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population. Conclusion: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest. © 2014 European Crohn's and Colitis Organisation.

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