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Alekhin A.P.,Moscow Physico Technical Institute | Lapushkin G.I.,Moscow Physico Technical Institute | Markeev A.M.,Moscow Physico Technical Institute | Sigarev A.A.,Moscow Physico Technical Institute | Toknova V.F.,Moscow Physico Technical Institute
Russian Journal of General Chemistry | Year: 2010

Using the methods of Rutherford backscattering spectrometry, X-ray photoelectron spectroscopy, X-ray diffraction in the geometry of the grazing beam, and Fourier transform infrared spectroscopy, we studied the chemical composition and structure of thin films of titanium dioxide formed by atomic layer deposition from tetraethoxytitanium and water. It is shown that the films obtained are characterized by a high stoichiometry of composition and by amorphous or polycrystalline structure of the anatase modification, depending on the number of reaction cycles. Using a model of the process of atomic layer deposition that takes into account the size and number of ligands of the reacting molecules, we calculated the amount of titanium dioxide deposited in a single reaction cycle. © 2010 Pleiades Publishing, Ltd.

Tareyeva E.E.,Russian Academy of Sciences | Schelkacheva T.I.,Russian Academy of Sciences | Chtchelkatchev N.M.,Moscow Physico Technical Institute
Theoretical and Mathematical Physics(Russian Federation) | Year: 2015

This paper is a review. We outline the main directions in the modern theory of spin glasses. The main content is based on our recent papers, devoted to studying replica symmetry breaking in non-Ising spin glasses. Studying a series of generalized models showed a certain uniformity of the behavior of these generalized spin glasses. Essentially, we observe a significant difference between their behavior and the behavior of the known systems with random couplings of Ising spins—the Sherrington-Kirkpatrick model and the corresponding p-spin model. We find the bifurcation point for the solution with the first replica symmetry breaking, study the form and stability of the solution near the bifurcation point, and show in which cases the transition to the glass state occurs continuously and in which cases, with a jump of the order parameters. © 2015, Pleiades Publishing, Ltd.

Matskeplishvili S.T.,Russian Academy of Medical Sciences | Prokhorchuk E.B.,Russian Academy of Sciences | Arutyunova Ya.E.,Russian Academy of Medical Sciences | Koksheneva I.V.,Russian Academy of Medical Sciences | And 5 more authors.
Cardiovascular Therapy and Prevention (Russian Federation) | Year: 2013

Aim: To study the associations between genetic polymorphisms and the development of clopidogrel resistance in patients referred for percutaneous coronary interventions (PCI).Material and methods: The study included 84 patients with coronary heart disease (CHD), who underwent planned PCI. Dynamic assessment of platelet aggregation was performed using light transmission aggregometry method (two-channel laser analyser Biola-230LA). The role in the development of inadequate suppression of platelet aggregation during the standard-dose dual antiplatelet therapy (DAT) was investigated for the following genes and polymorphic alleles: CYP2C19 (rs4244285∗2, rs4986893∗3, rs28399504∗, rs56337013∗5, and rs12248560∗17); CYP2C9 (rs1057910∗3); CYP3A4 (rs2242480); CYP2B6 (rs3211371 (5∗); CYP3A5 (rs28365083∗2 and rs776746); and CYP1A2 (rs762551).Results: The two study groups demonstrated a statistically significant difference in the prevalence of CYP2C19 rs4244285 (2∗) polymorphisms, with an increase in GA and AA genotypes and a reduction in the "wild" GG genotype (X2=11,7; p=0,003). The GA genotype was associated with inadequate suppression of platelet aggregation in patients receiving clopidogrel (75 mg/d) and aspirin (300 mg/d; odds ratio 6,27; 95% confidence interval 1,8-21,69). No significant inter-group differences were observed for other polymorphisms (CYP2C9 (rs1057910∗3); CYP3A4 (rs2242480); CYP2B6 (rs3211371 (5∗)); CYP3A5 (rs28365083∗2, rs776746); and CYP1A2 (rs762551)).Conclusion: The degree of platelet aggregation in patients on DAT is related to their genetic status. The assessment of genetic polymorphisms can facilitate the choice of optimal therapeutic strategies in clopidogrel-resistant patients. Patients with the CYP2C19 2∗ polymorphism are in particular need for an additional correction of the antiaggregant treatment scheme.

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