Hoffman W.H.,Georgia Regents University |
Hoffman W.H.,University of Michigan |
Hoffman W.H.,Wayne State University |
Hoffman W.H.,Morris od Jr Comprehensive Diabetes Center |
And 16 more authors.
Brain Research | Year: 2010
Gray and white matter structural deficits may accompany type 1 diabetes. Earlier experimental studies have demonstrated neuronal deficits associated with impaired neurotrophic support, inflammation and oxidative stress. In this study we demonstrate in two patients with histories of poorly controlled type 1 diabetes and fatal brain edema of ketoacidosis neuronal deficits associated with a decreased presence of insulin and IGF-1 receptors and accumulation of nitrotyrosin in neurons of affected areas and the choroid plexus. The findings add support to the suggested genesis of T1DM encephalopathy due to compromised neurotrophic protection, oxidative stress, inflammation and neuronal deficits, as demonstrated in T1DM encephalopathy in the BB/Wor-rat. © 2010.