Iwate, Japan
Iwate, Japan

Morioka University is a private university in Takizawa, Iwate, Japan. Established in 1981, the predecessor of the school was founded in 1950 as a specialty school.Morioka Daigaku Junior College was founded in 1964 as Seikatsu Gakuen Tankidaigaku . In April 1990, it was renamed Morioka Daigaku Junior College. Wikipedia.

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Arakaki M.,Tohoku University | Ishikawa M.,U.S. National Institutes of Health | Nakamura T.,Tohoku University | Iwamoto T.,Tohoku University | And 7 more authors.
Journal of Biological Chemistry | Year: 2012

Epithelial-mesenchymal interactions regulate the growth and morphogenesis of ectodermal organs such as teeth. Dental pulp stem cells (DPSCs) are a part of dental mesenchyme, derived from the cranial neural crest, and differentiate into dentin forming odontoblasts. However, the interactions between DPSCs and epithelium have not been clearly elucidated. In this study, we established a mouse dental pulp stem cell line (SP) comprised of enriched side population cells that displayed a multipotent capacity to differentiate into odontogenic, osteogenic, adipogenic, and neurogenic cells. We also analyzed the interactions between SP cells and cells from the rat dental epithelial SF2 line. When cultured with SF2 cells, SP cells differentiated into odontoblasts that expressed dentin sialophosphoprotein. This differentiation was regulated by BMP2 and BMP4, and inhibited by the BMP antagonist Noggin.Wealso found that mouse iPS cells cultured with mitomycin C-treated SF2-24 cells displayed an epithelial cell-like morphology. Those cells expressed the epithelial cell markers p63 and cytokeratin-14, and the ameloblast markers ameloblastin and enamelin, whereas they did not express the endodermal cell marker Gata6 or mesodermal cell marker brachyury. This is the first report of differentiation of iPS cells into ameloblasts via interactions with dental epithelium. Co-culturing with dental epithelial cells appears to induce stem cell differentiation that favors an odontogenic cell fate, which may be a useful approach for tooth bioengineering strategies.


Sakajiri T.,Tokyo University of Science | Sakajiri T.,Morioka College | Yamamura T.,Morioka College | Kikuchi T.,Ritsumeikan University | And 3 more authors.
Biological Trace Element Research | Year: 2010

Human transferrin (Tf) very tightly binds two ferric ions to deliver iron to cells. Fe(III)2Tf (Fe2Tf) binds to the Tf receptor (TfR) at pH 7.4; however, iron-free Tf (apoTf) does not. Iron uptake is facilitated by endocytosis of the Fe2Tf-TfR complex. Tf can also bind aluminum ions, which cause toxic effects and are associated with many diseases. Since Al(III)2Tf (Al2Tf) does not bind to TfR, the uptake of aluminum by the cells does not occur through a TfR-mediated pathway. We have studied the absence of binding between Al2Tf and TfR by investigating the physicochemical characteristics of apoTf, Al2Tf, Fe2Tf, and TfR. The hydrodynamic radius of 38.8 Å for Al 2Tf obtained by dynamic light scattering was between that of 42.6 Å for apoTf and 37.2 Å for Fe2Tf. The ζ potential of -11.3 mV for Al2Tf measured by capillary electrophoresis was close to -11.2 mV for apoTf as compared to -11.9 mV for Fe2Tf, indicating that the Al2Tf surface had a relatively scarce negative charge as the apoTf surface had. These results demonstrated that the structure of Al 2Tf was a trade-off between the closed and open forms of Fe 2Tf and apoTf, respectively. Consequently, it is suggested that Al2Tf cannot form specific ionic interresidual interactions, such as those formed by Fe2Tf, to bind to TfR, resulting in impossible complex formation between Al2Tf and TfR. © 2009 Humana Press Inc.


Li L.,Yonsei University | Kwon H.-J.,Yonsei University | Harada H.,Morioka College | Ohshima H.,Niigata University | And 2 more authors.
Gene Expression Patterns | Year: 2011

Recent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor. © 2010 Elsevier B.V. All rights reserved.


Sawada T.,Morioka College | Yokoi K.,Seitoku University
European Journal of Clinical Nutrition | Year: 2010

The relation of zinc (Zn) nutriture to brain development and function has been elucidated. The purpose of this study is to examine whether Zn supplementation improves mood states in young women. The study used a double-blind, randomized and placebo-controlled procedure. The major outcomes were psychological measures, somatic symptoms and serum Zn. Thirty women were placed randomly and in equal numbers into two groups, and they ingested one capsule containing multivitamins (MVs) or MV and 7 mg Zn daily for 10 weeks. Women who took MV and Zn showed a significant reduction in anger-hostility score (P=0.009) and depression-dejection score (P=0.011) in the Profile of Moods State (POMS) and a significant increase in serum Zn concentration (P0.008), whereas women who took only MV did not. Our results suggest that Zn supplementation may be effective in reducing anger and depression. © 2010 Macmillan Publishers Limited All rights reserved.


PubMed | Morioka College
Type: Journal Article | Journal: European journal of clinical nutrition | Year: 2010

The relation of zinc (Zn) nutriture to brain development and function has been elucidated. The purpose of this study is to examine whether Zn supplementation improves mood states in young women. The study used a double-blind, randomized and placebo-controlled procedure. The major outcomes were psychological measures, somatic symptoms and serum Zn. Thirty women were placed randomly and in equal numbers into two groups, and they ingested one capsule containing multivitamins (MVs) or MV and 7 mg Zn daily for 10 weeks. Women who took MV and Zn showed a significant reduction in anger-hostility score (P=0.009) and depression-dejection score (P=0.011) in the Profile of Moods State (POMS) and a significant increase in serum Zn concentration (P=0.008), whereas women who took only MV did not. Our results suggest that Zn supplementation may be effective in reducing anger and depression.


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