Dixon Lane-Meadow Creek, CA, United States
Dixon Lane-Meadow Creek, CA, United States

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Zhang Y.-K.,Anacor Pharmaceuticals Inc. | Plattner J.J.,Anacor Pharmaceuticals Inc. | Easom E.E.,Anacor Pharmaceuticals Inc. | Liu L.,Anacor Pharmaceuticals Inc. | And 3 more authors.
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2012

Two new isotopically labeled compounds, (carboxy- 13C-3,3- 2H 2)-7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (2) and (3- 14C)-7-(2-carboxyethyl)-1,3-dihydro-1- hydroxy-2,1-benzoxaborole (3), were designed and synthesized to support the preclinical development studies of a potential new antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1). Copyright © 2012 John Wiley & Sons, Ltd.


Kozocas J.A.,SRI International | Bupp J.E.,SRI International | Tanga M.J.,SRI International | Pluhar J.T.,Moravek Biochemicals Inc. | Wainer I.W.,U.S. National Institute on Aging
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2010

The preparation of 2′,4′,6′-[3H 3]-(R,R)-4-methoxyfenoterol, a tritium-labeled derivative of (R,R)-4-methoxyfenoterol was demonstrated on a 15 mCi scale providing material with a specific activity of 57 Ci/mmol. Copyright © 2009 John Wiley & Sons, Ltd.


Latli B.,Boehringer Ingelheim Pharmaceuticals | Hrapchak M.,Boehringer Ingelheim Pharmaceuticals | Switek H.-K.,Boehringer Ingelheim | Retz D.M.,Moravek Biochemicals Inc. | And 2 more authors.
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2010

Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbon-14-labeled ambroxol with the radioactive atom(s) either on the benzylic carbon or uniformly in the cyclohexyl ring with specific activities of 59 and 81 mCi/mmol, respectively. We also describe the preparation of deuterium-labeled ambroxol, its deuterium-labeled tetrahydroquinazoline metabolite (DHTQ), carbon-13-labeled 3,5-dibromoanthranilic acid metabolite, as well as an unlabeled O-glucuronide conjugate. Copyright © 2009 John Wiley & Sons, Ltd.


Immoos J.E.,Moravek Biochemicals Inc.
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2015

A novel method for the preparation of isoeugenol, [ring-(U)-14C] is presented. Phenols and phenyl esters substituted in the para position with 1-hydroxyethyl or 1-hydroxypropyl acetate esters when treated with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide (DMF) eliminate the alkyl carboxylate function to give the unsaturated compound. The reaction fails with unsubstituted or ether substituted phenyl 1-hydroxyacetate esters. © 2015 John Wiley & Sons, Ltd.


Gomez L.,Johnson and Johnson Pharmaceutical Research and Development L.L.C. | Wu J.,Johnson and Johnson Pharmaceutical Research and Development L.L.C. | Mani N.S.,Johnson and Johnson Pharmaceutical Research and Development L.L.C. | Basu S.,Moravek Biochemicals Inc. | And 2 more authors.
Tetrahedron Letters | Year: 2010

Attempts to prepare JNJ 26273364, a highly functionalized pyrazole-based CCK1 receptor antagonist, using a carboxylation reaction led to a series of unexpected results. This work demonstrated the unique reactivity and stability of the highly functionalized Z-alkene functionality present around the pyrazole. © 2009 Elsevier Ltd. All rights reserved.


PubMed | Moravek Biochemicals Inc.
Type: Journal Article | Journal: Journal of labelled compounds & radiopharmaceuticals | Year: 2015

A novel method for the preparation of isoeugenol, [ring-(U)-(14)C] is presented. Phenols and phenyl esters substituted in the para position with 1-hydroxyethyl or 1-hydroxypropyl acetate esters when treated with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide (DMF) eliminate the alkyl carboxylate function to give the unsaturated compound. The reaction fails with unsubstituted or ether substituted phenyl 1-hydroxyacetate esters.

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