PubMed | Tel Aviv University, Innsbruck Medical University, Tel Aviv Sourasky Medical Center Tel Aviv, Montreal Neurological Institute and 9 more.
Type: Journal Article | Journal: Annals of clinical and translational neurology | Year: 2015
Rapid eye movement sleep behavior disorder and GBA mutations are both associated with Parkinsons disease. The GBA gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (n=265), and compared to controls (n=2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinsons disease cohort (n=120). GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P<0.0001) for rapid eye movement sleep behavior disorder, and among Parkinsons disease patients, the OR for mutation carriers to have probable rapid eye movement sleep behavior disorder was 3.13 (P=0.039). These results demonstrate that rapid eye movement sleep behavior disorder is associated with GBA mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinsons disease.