The University of Montpellier was a French university in Montpellier Hérault, in Languedoc-Roussillon region in south-east France. Its present-day university legacy has been renamed and is currently known as the University of Montpellier 1, Montpellier 2 University and Paul Valéry University, Montpellier III until 2015 when l'université de Montpellier was created a second time. Moreover, the prestigious and famous secondary high-school Lycée Joffre is also a direct heir from the outstanding Montpellier University system. Wikipedia.
Sibille N.,Montpellier University
Biochemical Society transactions | Year: 2012
In recent years, IDPs (intrinsically disordered proteins) have emerged as pivotal actors in biology. Despite IDPs being present in all kingdoms of life, they are more abundant in eukaryotes where they are involved in the vast majority of regulation and signalling processes. The realization that, in some cases, functional states of proteins were partly or fully disordered was in contradiction to the traditional view where a well defined three-dimensional structure was required for activity. Several experimental evidences indicate, however, that structural features in IDPs such as transient secondary-structural elements and overall dimensions are crucial to their function. NMR has been the main tool to study IDP structure by probing conformational preferences at residue level. Additionally, SAXS (small-angle X-ray scattering) has the capacity to report on the three-dimensional space sampled by disordered states and therefore complements the local information provided by NMR. The present review describes how the synergy between NMR and SAXS can be exploited to obtain more detailed structural and dynamic models of IDPs in solution. These combined strategies, embedded into computational approaches, promise the elucidation of the structure-function properties of this important, but elusive, family of biomolecules.
Feil R.,Montpellier University |
Fraga M.F.,CSIC - National Center for Biotechnology |
Fraga M.F.,University of Oviedo
Nature Reviews Genetics | Year: 2012
Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable chromatin modifications. There has been considerable interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and could thereby influence gene expression and phenotype. Chemical pollutants, dietary components, temperature changes and other external stresses can indeed have long-lasting effects on development, metabolism and health, sometimes even in subsequent generations. Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems. These have implications for structuring future research and understanding disease and development. © 2012 Macmillan Publishers Limited. All rights reserved.
Andreev S.V.,Montpellier University
Physical Review Letters | Year: 2013
We explain the experimentally observed instability of cold exciton gases and the formation of a macroscopically ordered exciton state in terms of a thermodynamic model accounting for the phase fluctuations of the condensate. We show that the temperature dependence of the exciton energy exhibits fundamental scaling behavior with the signature of the second order phase transition. © 2013 American Physical Society.
Grimanelli D.,Montpellier University
Current Opinion in Plant Biology | Year: 2012
Apomictic plants reproduce asexually through seeds by avoiding both meiosis and fertilization. While apomixis is genetically controlled, individual loci contributing to its expression have yet to be identified. Here, we review recent results indicating that RNA-dependent DNA methylation pathways acting during female reproduction are essential for proper reproductive development in plants, and may represent key regulators of the differentiation between apomictic and sexual reproduction. © 2011 Elsevier Ltd.
Venables J.P.,Montpellier University
Nature communications | Year: 2013
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has provided huge insight into the pathways, mechanisms and transcription factors that control differentiation. Here we use high-throughput RT-PCR technology to take a snapshot of splicing changes in the full spectrum of high- and low-expressed genes during induction of fibroblasts, from several donors, into iPSCs and their subsequent redifferentiation. We uncover a programme of concerted alternative splicing changes involved in late mesoderm differentiation and controlled by key splicing regulators MBNL1 and RBFOX2. These critical splicing adjustments arise early in vertebrate evolution and remain fixed in at least 10 genes (including PLOD2, CLSTN1, ATP2A1, PALM, ITGA6, KIF13A, FMNL3, PPIP5K1, MARK2 and FNIP1), implying that vertebrates require alternative splicing to fully implement the instructions of transcriptional control networks.