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Lake Success, NY, United States

Yancoskie A.E.,The New School | Frank D.K.,The New School | Fantasia J.E.,The New School | Savona S.,The Monter Cancer Center | And 3 more authors.
Head and Neck Pathology | Year: 2015

Giant cell tumor of the larynx (GCTL) is a rare entity; only 34 cases have been reported in the literature. We report a case of GCTL in a 46 year-old male presenting clinical, radiographic, histological and therapeutic features. Previously reported cases are also reviewed. © 2015, Springer Science+Business Media New York.

Avritscher E.B.C.,University of Texas M. D. Anderson Cancer Center | Avritscher E.B.C.,The Monter Cancer Center | Avritscher E.B.C.,University of Vermont | Shih Y.T.,University of Texas M. D. Anderson Cancer Center | And 17 more authors.
Journal of Supportive Oncology | Year: 2010

We estimated the cost-utility of palonosetron-based therapy compared with generic ondansetron-based therapy throughout four cycles of anthracycline and cyclophosphamide for treating women with breast cancer. We developed a Markov model comparing six strategies in which ondansetron and palonosetron are combined with either dexamethasone alone, dexamethasone plus aprepitant following emesis, or dexamethasone plus aprepitant up front. Data on the effectiveness of antiemetics and emesis-related utility were obtained from published sources. Relative to the ondansetron-based two-drug therapy, the incremental cost- effectiveness ratios for the palonosetron-based regimens were $115,490/quality-adjusted life years (QALY) for the twodrug strategy, $199,375/QALY for the two-drug regimen plus aprepitant after emesis, and $200,526/QALY for the three-drug strategy. In sensitivity analysis, using the $100,000/QALY benchmark, the palonosetronbased two-drug strategy and the two-drug regimen plus aprepitant following emesis were shown to be cost-effective in 39% and 26% of the Monte Carlo simulations, respectively, and with changes in values for the effectiveness of antiemetics and the rate of hospitalization. The cost-utility of palonosetron-based therapy exceeds the $100,000/QALY threshold. Future research incorporating the price structure of all antiemetics following ondansetron's recent patent expiration is needed. © 2010 Published by Elsevier Inc.

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