Monash University is a university based in Melbourne, Australia. It was founded in 1958 and is the second oldest university in the State of Victoria. Monash is a member of Australia's Group of Eight and the ASAIHL, and is the only Australian member of the influential M8 Alliance of Academic Health Centers, Universities and National Academies.Monash enrolls approximately 45,000 undergraduate and 17,000 graduate students, making it the university with the largest student body in Australia. It also has more applicants than any university in the state of Victoria.Monash is home to major research facilities, including the Australian Synchrotron, the Monash Science Technology Research and Innovation Precinct , the Australian Stem Cell Centre, 100 research centres and 17 co-operative research centres. In 2011, its total revenue was over $1.5 billion, with external research income around $282 million.The university has seven campuses, five of which are in Victoria , one in Malaysia, and one in South Africa. Monash also has a research and teaching centre in Prato, Italy, a graduate research school in Mumbai, India and a graduate school in Jiangsu Province, China. Since December 2011, Monash has had a global alliance with the University of Warwick in the United Kingdom.The Clayton campus contains the Robert Blackwood Hall, named after the university's founding Chancellor Sir Robert Blackwood and designed by Sir Roy Grounds, which boasts superb acoustics and is considered Melbourne's best music venue outside the CBD.In 2014, the University ceded its Gippsland campus to Federation University. Wikipedia.
Monash University | Date: 2017-02-08
The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.
Monash University, University of South Australia and Sa Pathology | Date: 2017-05-03
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such 5 compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.
KaloBios Pharmaceuticals, Monash University and Ludwig Institute for Cancer Research | Date: 2017-08-02
The invention provides methods and compositions comprising anti-EphA3 antibodies for the treatment of solid tumors.
Monash University and Alfred Health | Date: 2017-04-05
A magnetic circuit (400) comprises a magnetic path which includes at least one magnetic source (102) arranged to generate magnetic flux within the magnetic path. A magnetic flux-concentrating element 402 is magnetically coupled to the magnetic source, and arranged to concentrate magnetic-flux generated by the magnetic source within a volume adjacent to the magnetic flux-concentrating element (402). Some embodiments of the magnetic circuit (400) comprise at least first (102) and second (104) magnetic sources, which may advantageously be arranged to generate magnetic flux in a common direction within the magnetic path.
Monash University | Date: 2017-01-18
A gas permeable or breathable electrode and method of manufacture thereof. In one example there is an electrolytic cell having an electrode comprising a porous material, wherein gas produced at the electrode diffuses out of the cell via the porous material. In operation the gas is produced at the at least one electrode without substantial bubble formation. In another example there is an electrode having a porous conducting material with a hydrophobic layer or coating applied to a side of the porous conducting material. A catalyst may be applied to another side. The gas permeable or breathable electrode can be used in an electrolytic cell, electrochemical cell, battery and/or fuel cell. Gas produced at the electrode diffuses out of a cell via at least part of the electrode, separating the gas from the reaction at the electrode.
Monash University | Date: 2017-03-08
An ultrafiltration membrane comprising: (i) a first polymer, and (ii) a second, charged polymer wherein the first polymer and second polymer have different hydrophobicities.
Monash University | Date: 2017-04-19
The present invention generally relates to methods of preparing leukocytes, particularly T cells, ex vivo for use in immunotherapy, particularly cancer immunotherapy. More specifically, the invention relates to methods for the preparation of leukocytes exhibiting cytotoxic properties for use in adoptive cell transfer. The invention also relates to cells and compositions including them for cancer immunotherapy. The invention also relates to methods of immunotherapy, particularly cancer immunotherapy. The present invention relates to a method for producing a leukocyte that has an enhanced capacity for killing a target cell, the method including contacting the leukocyte with a PTPN2 inhibitor in conditions for enabling the inhibitor to inactivate PTPN2 in the leukocyte, thereby producing a leukocyte that has an enhanced capacity for killing a target cell. Preferably, the leukocyte is contacted with the PTPN2 inhibitor in the absence of a T helper cell.
Monash University | Date: 2017-02-01
A visual image processing method is based on received spatial field information (302) from a spatial field sensor (116). A data store (804) is accessed, which contains a sensor map data structure (206) comprising a set of predefined regions (208) within a spatial field corresponding with the information received via the sensor input. Each predefined region is associated in the data structure with one or more of a set of stimuli (204) applicable to a biological visual system, and each stimulus corresponds with a visual percept (210). The spatial field information associated with each region is processed to generate stimulus control information which is applied to select, from within the sensor map data structure, stimuli from the set of stimuli for application to the biological visual system. Output stimulus signals (310) are generated, which are suitable for application to the biological visual system based upon the selected stimuli. Flexible mappings are thus provided between visual percepts, stimuli which may be applied (e.g. via a prosthetic implant) in order to generate the percepts, and associations between those stimuli and regions of the spatial field corresponding with the visual percepts.
Monash University | Date: 2017-06-21
H:\dar\Interwoven\NRPortbl\DCC\DAR\8230712_1.doc-12/08/2015 Abstract The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
Monash University, La Trobe University, Peptides International Inc. and Baylor College of Medicine | Date: 2017-06-21
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X-4 is D, E or other negatively-charged amino acid or derivative thereof, X-3 is E, I, L, S, V, W or a tryptophan derivative, X-2 is any amino acid, X-1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety.