Kasukabe, Japan
Kasukabe, Japan

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Nagata Y.,Momoya Co. | Nagata Y.,Kagawa Nutrition University | Yoshida M.,Momoya Co. | Kitazawa H.,Tohoku University | And 2 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2010

We conducted two randomized, placebo-controlled, double-blind studies of Lactobacillus plantarum No. 14 (LP14) in female students with seasonal allergic diseases. We also examined the mitogenic activity and cytokine inducibility of LP14 using Peyer's patch cells and mesenteric lymph node cells of swine. For subjects who took 8.7 x 108 of LP14, a significant improvement in ocular symptom-medication score was observed. In the placebo group, the T helper type 1 (Thl)/T helper type 2 (Th2) ratio tended to decrease after a 6-week intake period, while in the LP14 group, the percentage of Thl cells significantly increased. Post-intake eosinophil counts significantly increased in comparison to those at intake cessation in the placebo group, but it appeared to be suppressed in the LP14 group. There were no changes in fecal microflora. LP14 strongly induced the gene expression of Thl-type cytokines. This study indicates the clinical effects of LP14 on seasonal allergic diseases.

Nagata Y.,Momoya Co. | Nagata Y.,Kagawa Nutrition University | Yoshida M.,Momoya Co. | Araki E.,Kagawa Nutrition University | Gomyo T.,Kagawa Nutrition University
Food Science and Technology Research | Year: 2012

The effects of single administration of Lactobacillus plantarum No. 14 (LP14) on human body temperature and factors related to sympathetic nerves were measured in a randomized, double-blind, cross-over study. LP14 significantly increased chest temperature (P < 0.05). The maximum difference in temperature between LP14 and placebo was 0.24 ± 0.24°C. Systolic blood pressure increased significantly, and arousal scores tended to increase in the LP14 group. The results of the Uchida-Kraepelin test indicated that LP14 elevated task performance. Our results demonstrated that LP14 induced thermogenesis in humans. We also examined the activity of the sympathetic nerves (SNA) innervating brown adipose tissue (BAT) in rats. The activity of BAT-SNA was significantly enhanced in the LP14 group. As LP14 changed factors associated with sympathetic nerves in humans and elevated sympathetic nerve activity in rats, sympathetic nerve activation appears to participate in thermogenesis elicited by LP14.

Kamimura Y.,Momoya Co. | Hashiguchi K.,Momoya Co. | Nagata Y.,Momoya Co. | Saka T.,Momoya Co. | And 3 more authors.
Nippon Shokuhin Kagaku Kogaku Kaishi | Year: 2010

We investigated the effect of edible green algae Mono-stroma nitidum on glycemic responses after oral adminis-tration of various saccharinity agents. Male Wister rats (6-8 weeks old) were administered 2g/kg b.w. glucose, sucrose, maltose or soluble starch with or without 0.2 g/kg b.w. M. nitidum powder. M. nitidum significantly inhibited the increment of plasma glucose level (p<0.01). When we examined the three fractions of M. nitidum, that is to say, MeOH-soluble one, hot water-soluble one (crude rhamnan sulfate extract) and insoluble one on glycemic responses, rats administered crude rhamnan sulfate ex-tract showed significantly lower plasma glucose level than the controlled group (p<0.01). Furthermore, the effects of M. nitidum and rhamnan sulfate on the post-prandial increase in blood glucose level were evaluated in healthy adults. The significant deduction of the blood glucose level was observed at 30 minutes after the intake of M. nitidum powder or crude rhamnan sulfate extract compared to the controlled ones (p<0.05). These results suggests that the M.nitidum and rhamnan sulfate are useful for diabetes mellitus.

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