Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.8 | Award Amount: 4.05M | Year: 2010
The objective of this project is to develop a miniaturized cheap and disposable photonic device for bio sensing that is capable of performing quantitative diagnostic tests that are currently limited to a hospital laboratory setting. Our target product is a disposable device for monitoring cardiovascular health - an EU-wide healthcare priority. To date Microfluidic (or Lab-on-a-Chip) devices have not been well suited to point-of-care applications. Although the chips themselves are cheap and small, they must generally be used in conjunction with bulky optical light-sources and detectors. The lack of an integrated, versatile detection scheme is a major obstacle to the deployment of portable diagnostic devices. Consortium partners have demonstrated that integration of organic diodes and photodetectors is a viable route to meet this need. The purpose of this proposal is to develop a radically new generation of devices, in which organic photonic field-effect transistors are used for both light generation and detection. The use of transistors in place of diodes has four principle benefits. Firstly they can be pre-fabricated on the substrate (the microfluidic chip), ensuring optimal registration between the organic photonic components and the underlying fluidic architecture. Secondly the devices can be completed by depositing a single layer of organic semiconductor followed by the gate electrode, thus avoiding the need for complex multilayered structures. Thirdly in-plane light generation by the transistors provides improved optical coupling into wave-guiding structures, leading to significant performance gains. And fourthly current-multiplying auxiliary transistors can also be included thereby enabling immediate amplification of the signal at the point-of-generation. In combination these factors offer a compelling solution to the challenge of point-of-care detection that will offer unprecedented sensitivity and superior reliability at a markedly reduced cost
Yamazaki M.,Imperial College London |
Hofmann O.,Molecular Vision Ltd |
Ryu G.,Molecular Vision Ltd |
Xiaoe L.,Imperial College London |
And 5 more authors.
Lab on a Chip - Miniaturisation for Chemistry and Biology | Year: 2011
We describe a simple technique for fabricating non-emissive colour filters based on the sensitisation of a highly porous nanostructured metal-oxide film with a monolayer of dye molecules. Ultrafast electron transfer at the oxide/dye interface induces efficient quenching of photogenerated excitons in the dye, reducing the photoluminescence quantum yield by many orders of magnitude. The resultant filters exhibit much less autofluorescence than conventional colour filters (where the chromophore is dispersed in a glass or polymer host), and are a viable low cost alternative to interference filters for microfluidic devices and other applications requiring non-emissive filtering. © The Royal Society of Chemistry.
Leem D-S.,Imperial College London |
Wobkenberg P.H.,Imperial College London |
Huang J.,Molecular Vision Ltd. |
Anthopoulos T.D.,Imperial College London |
And 2 more authors.
Organic Electronics: physics, materials, applications | Year: 2010
We report the use of interlayer lithography for the micron-scale patterning of high conductivity poly(3,4-ethylendioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The interlayer method was used to fabricate PEDOT:PSS source and drain electrodes with conductivities >360 S/cm and pattern gaps≥4 lm for top-gate/bottom-contact organic field-effect transistors (OFETs). p-Type OFETs based on 2,8-difluoro-5,11-bis(triethylsilylethynyl)-anthradithiophene (diF-TESADT) and blends of diF-TESADT with poly(tri-arylamine) (PTAA) exhibited high hole mobilities of up to 1 and 0.25 cm2/V s, respectively, while ambipolar OFETs based on methanofullerene [6,6]-phenyl-C61-butyric acid methyl-ester (PCBM) exhibited respective electron and hole mobilities of 0.05 and 0.005 cm2/V s. Complementary voltage inverters based on the diF-TESADT/PTAA and PCBM OFETs exhibited excellent operating characteristics with wide noise margin and high signal gain, indicating that the interlayer method offers a viable route to cost efficient, solution-processed, and flexible organic electronics. © 2010 Elsevier B.V. All rights reserved.
Molecular Vision Ltd | Date: 2014-03-25
A photovoltaic device comprising a first electrode, a second electrode, an active layer between the two electrodes and an interlayer between the active layer and at least one of the electrodes. The interlayer is a conjugated polymer which is preferably in the amorphous phase. The device shows significantly improved voltage-current characteristics compared to prior art devices and is particularly suitable as a low light level detector.
MOLECULAR VISION Ltd | Date: 2012-08-10
This invention relates to a method of inducing fluid flow in a passive capillarity filled microfluidic device involving the use of a dual flow control reagent system, wherein the first flow control reagent is a surfactant which reduces surface tension of an aqueous fluid sample and the second flow control reagent is a viscosity enhancer.
Molecular Vision Ltd | Date: 2015-02-13
An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter 2, a planar detector 3, a lateral flow membrane 4 interposed between the emitter 2 and the detector 3, a conjugate pad 5 in fluid communication with a proximal end of the lateral flow membrane 4, the conjugate pad 5 comprising optically detectable tagging particles bound to a first assay component, a sample pad 6 in fluid communication with the conjugate pad 5 and arranged to receive the liquid sample, and a wicking pad 7 in fluid communication with a distal end of the lateral flow membrane 4. The lateral flow membrane 4 is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad 5 to the wicking pad 7 by capillary action. The lateral flow membrane 4 comprises at least one test region 8,12 comprising an immobilised second assay component for retaining the tagging particles in the test region 8,12 in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region 8,12 that is indicative of the concentration of the analyte in the liquid sample. The emitter 2 comprises an emission layer 9,16 of an organic electroluminescent material and the emission layer 9,16 is aligned with the test region 8,12 of the lateral flow membrane 4, whereby the emitter 2 is capable of illuminating the test region 8,12. The detector 3 comprises an absorption layer 10,15 of an organic photovoltaic material and the absorption layer 10,15 is aligned with the test region 8,12 of the lateral flow membrane 4, whereby the detector 3 is capable of detecting light from the test region 8,12.
MOLECULAR VISION Ltd | Date: 2012-08-10
This invention relates to a device for performing an assay to detect an analyte in a fluid sample comprising a channel with reagent deposits comprising a flow control reagent positioned at one or more defined locations therein and a method for producing such a device. In particular, the invention relates to a microfluidic device.
MOLECULAR VISION Ltd | Date: 2012-07-20
There is provided a device, such as a microfluidic device, for performing an assay including: a substrate comprising a channel, such as a microfluidic channel; at least one optical element having an input port arranged to be optically coupled to a light source; an output port optically coupled to at least a portion of the channel; and a light guide portion optically connecting the input port and output port; and a detection port optically coupled to said at least a portion of the channel. The device provides an improved geometry which addresses problems related to traditional orthogonal detection arrangements and in-line detection systems.
Molecular Vision Ltd | Date: 2010-07-28
Diagnostic preparations and diagnostic testing reagents for laboratory and scientific use, other than medical; chemicals used in industry and science. Diagnostic reagents for medical laboratory use and for medical use; diagnostic substances for medical use for sale in kit form, namely, diagnostic kits containing reagents for use in disease testing; diagnostic scanning agents for medical in-vivo use, diagnostic testing reagents for medical use, diagnostic preparations for medical and veterinary purposes; chemical reagents for medical and veterinary purposes; medical diagnostic reagents and test strips for use in detecting the presence of nucleic acid targets, and indicators of diseases, such indicators including enzymes, antigens, antibodies and nucleic acids; cotton swabs for medical purposes. Chemical and biological analytical systems and equipment, namely, plates, glass slides or chips having multi-well arrays that can be used in chemical analysis, biological analysis or patterning for scientific, laboratory or medical research use, portable detection and identification instruments using light sources and light detectors for detecting and identifying chemical and biological substances not for medical purposes; optical equipment and components in the nature of optical products, namely, optical transmitters, optical data links, transceivers, and optical communication link testers; telecommunications equipment and components, namely, portable and handheld digital electronic devices for recording, organizing, transmitting, manipulating, and reviewing text, data, image, and audio files, fiber-optic transceivers, fiber optic repeaters, converters and optimizers; semi-conductors; electronic components, namely, digital transmitters; computer hardware; computer software for data transmission in connection with test, signaling, measurement, chemical and biological analytical, optical, telecommunication, semi-conductor, medical, clinical information, network management, network security, engineering, and data acquisition applications; lasers for non-medical purposes; signal generators and analyzers, namely, digital signal processors, receivers of digital signals in the nature of telecommunications hardware; oscilloscopes; network and spectrum analyzers, namely, electronic detectors for observing and measuring the infrared spectrum, namely, infrared detectors; electronic testing meters, namely, flow meters; frequency counters in the nature of frequency meters; chromatographs for laboratory use; mass spectrometers for laboratory use; microfluidic chips; semiconductor light-sources, namely, portable detection and identification instruments using light sources and light detectors for detecting and identifying chemical and biological substances not for medical purposes; photodetectors in the nature of light or electromagnetic energy sensors; DNA and protein sequencers, namely, laboratory devices for detecting genetic sequences; equipment used to analyze food, water, biological fluids, biodefense substances and hazardous materials, petroleum products and pharmaceutical products, namely, flow cytometers and flow-based analyzers providing cell and particle analysis, detection, or counting for scientific, laboratory, and general research uses, centrifuges for scientific, laboratory, and general research, microscopic slides, laboratory filters, laboratory photochemical reactors, laboratory microarrays, laboratory incubators, and laboratory glassware. Medical and veterinary apparatus and instruments, namely, testing apparatus for blood, urine, biological fluids, biological materials in the nature of cells and tissue; medical and veterinary diagnostic test kits, namely, collection kits for blood, urine, biological fluids, biological materials and other substances and materials; medical, biological fluid and veterinary diagnostic test kits comprised primarily of urine collectors and blood collectors in the nature of specimen containers, containers for holding reagents and test samples in the nature of plastic bags, bottles and tubes for transmitting medical specimens and specimen cup holders, untreated and treated test strips, reagents, test stands, filters, centrifuge tubes, magnets, and electric heaters for use in detecting the presence of nucleic acid targets, and of indicators of diseases, such indicators including enzymes, antigens, antibodies and nucleic acids, for clinical or home use; lateral flow devices for medical, veterinary, and diagnostic uses, namely, flow cytometers and flow-based analyzers providing cell and particle analysis, detection, or counting for medical and medical diagnostic uses; untreated dipsticks for medical testing; apparatus for testing biological fluids, namely, blood and urine testing apparatus, and handheld devices for testing blood and urine. Technological services, and research and design relating thereto, in the field of biotechnology, namely, research, development, consulting, and providing information in the biotechnology field; scientific and laboratory research relating to diagnostic tests; computer programming; technical support services for electronic, signaling, measuring, analytical, and medical products, namely, troubleshooting, installation, administration, and monitoring in the nature of diagnosing problems with scientific, electronic, test, signaling, measurement, medical equipment, biological or chemical analytical equipment, parts, supplies and accessories, including products for laboratory, research, industrial, medical, and security and defense use, semiconductors, electronic and optical components in the nature of various electronic products and in the nature of optical products such as transmitters, data links, transceivers, and communication link testers, computer hardware and computer software, and computer software repair; design of measurement systems; environmental testing services; biodefense and homeland security testing, namely, biological, chemical, materials and environmental testing, and consultancy therefor; food analysis services in the nature of food safety, diagnostic, and quality testing; medical research services. Medical diagnostic services, medical services; veterinary diagnostic testing and clinical services, medical diagnostic testing and clinical services; medical clinic services; medical screening services; medical health and fitness assessment services, namely, medical diagnostic testing services; health and medical information services; advice, information and consultancy services for all of the aforesaid services; rental and leasing of medical equipment, and accompanying parts, supplies and accessories in connection therewith.
Molecular Vision Ltd | Date: 2012-09-04
Diagnostic preparations for medical laboratory and scientific use; diagnostic testing materials, namely, diagnostic reagents for laboratory and scientific use, other than for medical use; chemicals used in industry and science. Diagnostic preparations for medical and veterinary purposes; reagents for medical use in detecting the presence of nucleic acid targets, and indicators of diseases, such indicators including enzymes, antigens, antibodies and nucleic acids; reagents for use in detecting the presence of nucleic acid targets, and indicators of diseases, namely, immunodiagnostic reagents for cardiac tests, medical diagnostic reagents, and chemical reagents for medical use, such indicators including enzymes, antigens, antibodies and nucleic acids; medical diagnostic test strips for use in detecting the presence of nucleic acid targets, and indicators of diseases, such indicators including enzymes, antigens, antibodies and nucleic acids; * all aforementioned goods unrelated to gene analysis, gene expression and/or gene sequencing and unrelated to coronary artery disease and/or cardiac arrhythmia *. Medical and veterinary apparatus and instruments, namely, opto-electronic medical apparatus and instruments for performing diagnostic tests for cardiac markers in biological fluids; medical diagnostic apparatus and instruments, namely, opto-electronic diagnostic apparatus and instruments for performing diagnostic tests for cardiac markers in biological fluids; medical and veterinary diagnostic test kits consisting primarily of probes, buffers and reagents for use in cardiac marker testing; medical, biological fluid and veterinary diagnostic test kits comprised primarily of blood, plasma or serum collectors in the nature of apparatus for taking blood and apparatus for testing blood, plasma or serum; * all aforementioned goods unrelated to gene analysis, gene expression and/or gene sequencing and unrelated to coronary artery disease and/or cardiac arrhythmia *. Diagnostic services, namely, medical diagnostic testing, monitoring and reporting services; medical services relating to tests for cardiac disease; veterinary testing relating to tests for cardiac diseases; medical clinical services relating to tests for cardiac diseases; medical clinic services; health screening services; medical health and fitness assessment services, namely, prediction and assessment of health risks to individuals as providing an assessment of the risk or cause of cardiac disease; health and medical information services; advice, information and consultancy services for all of the aforesaid services; rental and leasing of medical equipment, parts supplies and accessories.