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Cui H.L.,Baker Heart and Diabetes Institute | Cui H.L.,Molecular Science and Biotechnology Institute | Guo B.,Molecular Science and Biotechnology Institute | Scicluna B.,Molecular Science and Biotechnology Institute | And 8 more authors.
Journal of Biological Chemistry | Year: 2014

Background: Cholesterol plays an important role in the pathogenesis of neurodegenerative diseases. Results: Prion infection increased abundance of cholesterol transporter ABCA1 but reduced its functionality. Stimulation of ABCA1 reduced the conversion of prion into the pathological form. Conclusion: ABCA1 plays a key role in pathogenesis of prion disease. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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