Molecular Genetics of Schizophrenia MGS Collaboration

United States

Molecular Genetics of Schizophrenia MGS Collaboration

United States

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Duan J.,NorthShore University HealthSystem | Duan J.,University of Chicago | Sanders A.R.,NorthShore University HealthSystem | Sanders A.R.,University of Chicago | And 21 more authors.
Human Molecular Genetics | Year: 2015

We searched a gene expression dataset comprised of 634 schizophrenia (SZ) cases and 713 controls for expression outliers (i.e., extreme tails of the distribution of transcript expression values) with SZ cases overrepresented compared with controls. These outlier genes were enriched for brain expression and for genes known to be associated with neurodevelopmental disorders. SZ cases showed higher outlier burden (i.e., total outlier events per subject) than controls for genes within copy number variants (CNVs) associated with SZ or neurodevelopmental disorders. Outlier genes were enriched for CNVs and for rare putative regulatory variants, but this only explained a small proportion of the outlier subjects, highlighting the underlying presence of additional genetic and potentially, epigenetic mechanisms. © The Author 2015. Published by Oxford University Press. All rights reserved.

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