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Sunnyvale, CA, United States

Molecular Devices, LLC is a supplier of high-performance bioanalytical measurement systems that accelerate and improve drug discovery and other life sciences research. Wikipedia.


Patent
Molecular Devices | Date: 2013-01-09

A system is provided for performing filter-based and monochromator-based measurements. The system includes a light source and a plurality of detectors. An excitation monochromator outputs a selected wavelength component of the excitation light. Emitted light from a sample follows a selected emission optical path. An emission monochromator outputs a selected wavelength component of the emitted light when part of the selected path. An interface cartridge includes emission light ports positioned to direct the emitted light from the sample along a corresponding optical path. The interface cartridge aligns a selected optical path with the main measurement optical axis. A movable sliding switch mechanism provides optical channels corresponding to positions on the sliding switch mechanism to complete a selected emission optical path. The position on the sliding switch mechanism is selected by moving the sliding switch mechanism to align the optical channel for the position with the main measurement optical axis.


Systems and methods for measuring a light intensity. An example photodetector measurement circuit comprises a photodetector that receives a light and generates a photodetector current indicative of the light intensity. The measurement circuit includes a first integrator coupled along a first signal path to the photodetector to generate a first voltage signal at a first integrator output indicative of an integral of the photodetector current level. A second integrator is configured to generate a second voltage signal at a second integrator output indicative of an integral of the photodetector current level. A differential amplifier receives the first voltage signal and the second voltage signal and generates a third output signal at a differential amplifier output indicative of a difference between the first voltage signal and the second voltage signal. The differential amplifier outputs the third voltage signal to an analog-to-digital conversion function (ADC function) input.


A computer-implemented method and system of fiber analysis and reconstruction of a fiber-containing biological sample perform efficient and accurate analysis of fiber morphology. The images of objects comprising fiber and/or branching structure are obtained by camera and/or other imaging devices. Variable modules are operable to obtain initial tracing seeds via adaptive threshold method for identifying tracing seeds candidates by local Principal Component Analysis (PCA) calculation and sorting out the seeds with low and high score. Each single fiber segment of interest is traced repeatedly utilizing PCA fitting calculation, and individual fiber segments are assembled by performing crossover matching calculation.


An apparatus for automatically conditioning a patch plate and a plenum of an electrophysiology measurement system is provided. An arm is linearly movable between a non-operative position and an operative position. An end effector mounted to one side of the arm is configured to condition the patch plate. Another end effector mounted to an opposite side of the arm is configured to condition the plenum. A linear actuator is coupled to the arm and is configured to drive movement of the arm between the operative position and the non-operative position. When the arm is positioned in the operative position, the arm is situated between the patch plate and the plenum.


Patent
Molecular Devices | Date: 2013-02-01

A method and apparatus for removing noise from a bioelectrical signal are provided. A main analog signal from a bioelectrical test probe and a gating signal are received. A main data stream associated with the main analog signal from the bioelectrical test probe is developed. An adaptive noise cancellation (ANC) unit operates to develop an output data stream by removing noise components from the main data stream in accordance with the reference data stream. If the gating signal indicates that the main analog signal was acquired during a period of bioelectrical activity then the ANC unit operates in a fixed mode, and if the gating signal indicates that the main analog signal was acquired during a period without bioelectrical activity then ANC unit operates in an adaptive mode.

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