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Seddik H.,Mohammed V Military Teaching Hospital | Rabhi M.,Mohammed V Military Teaching Hospital
Diagnostic and Therapeutic Endoscopy | Year: 2011

Partially or completely invaginated appendix mistaken for a polyp during colonoscopy and leading to intussusception is a rare situation. This paper describes our experience with two cases of appendiceal intussusception. In the first case, there was no underlying ileocecal abnormality, and, in the second case, histologic examination of the resected appendix and cecum revealed widespread foci of angiodysplasia, and this was thought to be the basis for the intussusception. The authors present reviews of the literature concerning clinical features and associated conditions and emphasize that failure to recognize this condition may result in unexpected complications such as consequent peritonitis in case of endoscopic removal. Copyright 2011 Hassan Seddik and Monsef Rabhi.

Akhaddar A.,Mohammed V Military Teaching Hospital | Akhaddar A.,Angers University Hospital Center | Mercier P.,Angers University Hospital Center | Diabira S.,Angers University Hospital Center | And 2 more authors.
Pan Arab Journal of Neurosurgery | Year: 2011

Growing skull fracture (GSF) is an uncommon complication of traumatic head injury in children. Its pathophysiology is not clearly established but linear skull fracture with dural tear could cause this condition. We report the case of a 2-year-old boy who presented with an enlarging parietal scalp mass 14 months after an episode of fall. Neuroimaging studies revealed a skull defect by a leptomeningeal cyst combined with a partial parietal lobe schizencephaly which apparently contributed to the development of the GSF. This could be the first of such an association reported in the literature.

Akhaddar A.,Mohammed V Military Teaching Hospital | Boulahroud O.,Mohammed V Military Teaching Hospital | Boucetta M.,Mohammed V Military Teaching Hospital
Surgical Infections | Year: 2011

Background: Spinal cord abscesses are rare. Acute lesions may present as spinal cord syndrome with back pain and fever, whereas chronic abscesses tend to have a less specific symptomatology, especially in elderly patients. Methods: Case report and review of the pertinent literature. Case Report: An 82-year old male with diabetes mellitus presented with a four-month history of backache and some difficulty walking without sphincter disturbance or fever. Spinal magnetic resonance imaging revealed a midthoracic intramedullary ring-like lesion that proved to be an abscess. Corticosteroids, gentamicin, and ciprofloxacin were given. The abscess resolved after three months. Conclusions: Classically, treatment of intramedullary abscesses involves surgical drainage of the abscess cavity and administration of appropriate antibiotics, although medical therapy alone may be appropriate in some cases. If the diagnosis is unclear or patients do not respond to medical management, surgical decompression should be performed. © 2011 Mary Ann Liebert, Inc.

Rahoui J.,Mohammed V University | Sbitti Y.,Mohammed V Military Teaching Hospital | Touil N.,Mohammed V University | Laraqui A.,Mohammed V University | And 9 more authors.
Medical Oncology | Year: 2014

The vascular endothelial growth factor (VEGF), a potent regulator of angiogenesis, is involved in the development and progression of breast cancer (BC). The functional +936C/T polymorphism of the VEGF-A gene has been implicated in BC susceptibility; however, published data are conflicting. In the current case–control study, we analyzed the association of the +936C/T polymorphism with BC risk and tumor markers expression, human epidermal growth factor receptor 2 (HER2/neu) and caner antigen 15.3 (CA 15.3) in Moroccan women. We genotyped the DNA of 70 BC patients and 70 healthy women by TaqMan SNP assays. The χ2 test and Fisher’s exact test were used for statistical analyses. The overall results revealed that there is no association between the +936C/T polymorphism and BC risk [p = 0.8; OR 0.87, 95 % CI (0.32–2.42)]. However, when we stratified the group of patients according to the status of tumor markers, a statistical significant association of +936C/T SNP and HER2/neu expression was observed (p = 0.009). In contrast, no association with the other tumor marker, CA 15.3, was found (p = 0.090). Thus, the +936C/T polymorphism seems to have a correlation with HER/neu expression in BC disease. © 2014, Springer Science+Business Media New York.

Rahoui J.,Mohammed V University | Laraqui A.,Mohammed V University | Sbitti Y.,Mohammed V Military Teaching Hospital | Touil N.,Mohammed V University | And 9 more authors.
Medical Oncology | Year: 2014

The main mediator of breast cancer (BC) angiogenesis is the vascular endothelial growth factor (VEGF). Variation of VEGF-A gene may influence the BC susceptibility. The present case-control study investigated the association of the four commonly studied single nucleotide polymorphisms (SNP) of VEGF-A, namely: -1154A/G (rs1570360), -2578C/A (rs699947), -634G/C (rs2010963) and -460T/C (rs833061) with BC susceptibility and aggressiveness in Moroccan women. After genomic DNA extraction, genotyping was performed by TaqMan SNP assays on 70 BC patients and 70 healthy women. The χ2 test was used to detect differences in the genotype frequencies of VEGF between the groups and to stratify genotypes by the clinico-pathological characteristics in patient's group. Women carriers of -1154AG + AA and -2578AC + AA VEGF genotypes had a reduced risk to develop BC [p = 0.018, OR 2.25 95 % CI (1.14-4.42) and p = 0.022, OR 2.26 95 % CI (1.12-4.58), respectively]. Carriers of -460CT and CT + CC genotypes had also a reduced risk to develop BC [p = 0.045, OR 2.63 95 % CI (1.19-5.84) and p = 0.043, OR 2.12 95 % CI (1.01-4.43), respectively]. Moreover, the A-1154A-2578G-634C-460 haplotype seems to have a protective effect against BC risk [p = 0.007, OR 2.41 95 % CI (1.27-4.55)]. Stratification for BC patients according to clinico-pathological characteristics reveals no association with any of VEGF-A SNPs. In conclusion, the data indicated significant associations of VEGF -1154A/G, -2578C/A and -460T/C polymorphisms with BC susceptibility in Moroccan individuals. These VEGF-A polymorphisms can be useful as predisposing genetic markers for BC. Further larger-scale studies are necessary to confirm our finding. © 2014 Springer Science+Business Media New York.

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