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Serji B.,Mohammed V University | Serji B.,Mohammed the First University | Souadka A.,Mohammed V University | Benkabbou A.,Mohammed V University | And 7 more authors.
Arab Journal of Urology | Year: 2016

Objective To verify the feasibility and safety of laparoscopic adrenalectomy for large tumours, as since it was described, the laparoscopic approach for adrenalectomy has become the 'gold standard' for small tumours and for large and non-malignant adrenal tumours many studies have reported acceptable results. Patients and methods This is a retrospective study from a general surgery department from January 2006 to December 2013 including 45 patients (56 laparoscopic adrenalectomies). We divided patients into two groups according to tumour size: <5 or ≥5 cm, we compared demographic data and peri- and postoperative outcomes. Results There was no statistical difference between the two groups for conversion rate (3.7% vs 11.7% P = 0.32), postoperative complications (14% vs 12%, P = 0.4), postoperative length of hospital stay (5 vs 6 days P = 0.43) or mortality (3.5% vs 0% P = 0.99). The only statistical difference was the operating time, at a mean (SD) 155 (60) vs 247 (71) min (P < 0.001). Conclusion Laparoscopic adrenalectomy for large tumours needs more time but appears to be safe and feasible when performed by experienced surgeons. © 2016 Arab Association of Urology. Production and hosting by Elsevier B.V.

Beyi L.,Mohammed the First University | Aziz M.,Mohammed the First University | Makrane H.,Mohammed the First University | Karim A.,Mohammed the First University | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The aqueous extract of the aerial-part of Cotula cinerea Del. was studied for antidiarrheal activity using castor oil induced diarrhea models in rats and gastrointestinal transit test in mice. At the doses of 50, 100 and 250 mg/kg, the aqueous extract significantly inhibited the castor oil-induced diarrhoea in a dose-response fashion latency and decreased eased the frequency of wet faeces when compared with untreated control rats effects. In addition, the extract has also decreased significantly the propulsion of charcoal meal through the gastrointestinal tract in mice. These findings suggested that the extract may contain biologically active components that may be useful against diarrhea.

Karim A.,Mohammed the First University | Zrouri H.,Mohammed the First University | Amrani S.,Mohammed the First University | Bnouham M.,Mohammed the First University | And 2 more authors.
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Objective: The aim of the present study was to investigate the effect of the organic extracts of Anthemis mauritiana (AM) Maire and Sennen (Asteraceae) flowers on the contractile responses of the rabbit and rat jejunums and its possible mechanisms. Methods: Soxhlet extraction with different successive solvents (petroleum ether, dichloromethane, ethyl acetate, and methanol) were prepared and evaluated by preliminary phytochemical test. Antispasmodic effects of the extracts were evaluated against spontaneous contractions of rabbit and rat jejunum contracted by carbachol and high K+ concentration. Results: The phytochemical screening analysis revealed that the extracts of AM flowers contain flavonoids and tannins with variable quantities. Petroleum ether and dichloromethane extracts showed the most relaxant effects in the rabbit jejunum at concentrations with IC50 valueof 9.31±2.65 µg/ml and 25.04±5.87 µg/ml respectively. Ethyl acetate showed a total inhibition at 1 mg/ml, but the methanol extract at 5 mg/ml. In contrast, the residual aqueous extract was a reverse activity. And also all extracts caused an inhibitory effect on both K + (75 mM) and CCh (10−6 M)induced contractions in the rat jejunum except aqueous fraction. The extracts that have antispasmodic activity induced a marked depression on cumulative concentrationresponse curve for carbachol and CaCl 2 . Conclusions: The results indicate that the antispasmodic effect decreased with the polarity of the organic extracts, but the aqueous fraction had a reverse effect. These results explain and confirm the popular use of genus of this plant for the treatment of gastrointestinal disturbances, and encourage studies on new compounds, in order to obtain new antispasmodic agents. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

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