Mohamed Ist University

Oujda, Morocco

Mohamed Ist University

Oujda, Morocco
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El Bairi K.,Mohamed Ist University | Amrani M.,Mohammed V University | Kandhro A.H.,Diagnostic Healthcare | Afqir S.,Mohamed University Hospital
Critical Reviews in Clinical Laboratory Sciences | Year: 2017

Therapy resistance is a major challenge in the management of ovarian cancer (OC). Advances in detection and new technology validation have led to the emergence of biomarkers that can predict responses to available therapies. It is important to identify predictive biomarkers to select resistant and sensitive patients in order to reduce important toxicities, to reduce costs and to increase survival. The discovery of predictive and prognostic biomarkers for monitoring therapy is a developing field and provides promising perspectives in the era of personalized medicine. This review article will discuss the biology of OC with a focus on targetable pathways; current therapies; mechanisms of resistance; predictive biomarkers for chemotherapy, antiangiogenic and DNA-targeted therapies, and optimal cytoreductive surgery; and the emergence of liquid biopsy using recent studies from the Medline database and © 2017 Informa UK Limited, trading as Taylor & Francis Group.

El Hafid L.,Mohamed Ist University | Mghizou S.,Mohamed Ist University | Kaoua M.,Sudan University of Science and Technology | Melhaoui M.,Mohamed Ist University | Chergui A.,Mohamed Ist University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Argan oil from- Beni Snassen natural Argan forest (East of Morocco)- displays a good nutritional value related to the high quality of its unsaturated fatty acid. Traditional processes of Argan oil extraction contribute to this quality. Fatty acid analysed by gas chromatography and the measure of peroxide index show that Argan oil traditionally extracted doesn't resist to oxidation and it's storage doesn't exceed 3 months. The quality of Argan oil is related to seeds storage conditions. The study of lipid composition evolution of Argan seeds during 5 months and at different storage conditions show that Argan seeds stored at low temperature (4°C) and in the freezer (- 20°C) present a stability of fatty acid composition than Argan oil from seeds stored in textile bags and black polyethylene bags at ambient temperature.

Chergui A.,Mohamed Ist University | El Hafid L.,Mohamed Ist University | Melhaoui M.,Mohamed Ist University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

A moderate hydric stress (polyethylene glycol concentration lower or equal to 90g/l) of 5 or 12 hours duration involves an increase in the content of soluble sugars in the roots of Ammophila arenaria compared to the witness, whereas a severe hydric stress (concentration higher than 90g/l) involves a reduction of sugars concentration. The sodium chloride concentrations lower or equal to 12g/l cause an important increase in the soluble sugars in the roots, in particular for the treatment of 5 hours, whereas the higher concentrations involve a reduction of soluble sugars level. Soluble sugars of the root seem to increase much more in response to the saline stress than with the hydric stress.

Beghlal D.,Blida University | El Bairi K.,Mohamed Ist University | Marmouzi I.,Mohammed V University | Haddar L.,Mohamed Ist University | Mohamed B.,Moulay Ismaï University
Asian Pacific Journal of Tropical Disease | Year: 2016

Objective: To study the phytochemical composition and organoleptic properties of Pistacia lentiscus (L.) (P. lentiscus) from Algeria and to investigate the antioxidant activities of its essential oil and ethanolic extract. Methods: Aerial parts of P. lentiscus were collected at Hammam Melouane (Blida), 50 km from Algiers. Different solvent extractions were made for the preliminary screening of phytochemicals. Additionally, the physicochemical and organoleptic properties of the Algerian variety have been characterized. Moreover, P. lentiscus essential oil and ethanolic extract were studied for their antioxidant potential by ferric reducing power test. Results: Phytochemical screening of P. lentiscus revealed the presence of various biochemicals, including leuco-anthocyanins, condensed tannins, gallic tannins, saponoside, coumarins, and flavonoids, while others were absent (anthocyanins and alcaloids). Essential oil showed lower antioxidant potential compared to the ethanolic extract, reflecting the potential phenolic content responsible for this activity. Conclusions: The present study reveals the presence of various phytochemical classes in P. lentiscus, and the antioxidant experiment shows a good bioactivity of the aerial parts of the Algerian P. lentiscus. The literature review of the essential oil composition shows also important variations due to geographic and environmental conditions. This preliminary investigation will help explore the bioactive compounds of P. lentiscus, and will bring data for a better physicochemical and organoleptic classification of the Algerian variety. © 2016 Asian Pacific Tropical Medicine Press.

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