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News Article | May 2, 2017

Last May a seemingly commonplace meeting kicked off a firestorm of controversy. More than 100 experts in genetics and bioengineering convened at Harvard Medical School for a meeting that was closed to the public — attendees were asked not to contact news media or to post about the meeting on social media. The same group is getting back together in New York City next week. To the meeting organizers, last year's secretive measures were, counterintuitively, to make sure as many people heard about the project as possible. They were submitting a paper about the project to a scientific journal and were discouraged from sharing the information publicly before it was published. But there's another reason why this group of scientists, while encouraging debate and public involvement, would be wary of attracting too much attention. Their project is an effort to synthesize DNA, including human DNA. Researchers will start with simpler organisms, such as microbes and plants, but hope to ultimately create strands of human genetic code. One of the group's organizers, Jef Boeke, director of the Institute for Systems Genetics at NYU School of Medicine, told CNBC that incorporating synthesized DNA into mammalian (or even human) cells could happen in four to five years. This project follows in the footsteps of the Human Genome Project (HGP), the 13-year, $2.7 billion project that enabled scientists to first decode the human genome. "HGP allowed us to read the genome, but we still don't completely understand it," said Nancy Kelley, the coordinator of the new effort, dubbed GP-write. High school biology covers the basic building blocks for DNA, called nucleotides — adenine (A), cytosine (C), guanine (G) and thymine (T). Humans' 3 billion pairs provide the blueprints for how to build our cells. The intention of GP-write is to provide a better fundamental understanding of how these pieces work together. Using synthesized genomes has both pragmatic and theoretical implications — it could lead to lower cost and higher quality of DNA synthesis, discoveries about DNA assembly in cells and the ability to test many DNA variations. "If you do that, you gain a much deeper understanding of how a complicated apparatus goes," Boeke said. Boeke likens the genome to a bicycle — you can only fully understand something once you take it apart and put it back together. "Really, a synthetic genome is an engine for learning new information." More from Modern Medicine: Medical breakthroughs are way behind for the hard of hearing In the land of Vikings, an ambitious effort to find a cancer cure New guidelines for prostate cancer screening Boeke is particularly excited about what he calls an "ultrasafe cell line." Certain types of mammalian cells intended to produce certain types of large molecule drugs, called biologics. "[Cell lines] have been cultured in dishes in labs for decades. But you can't engineer the genomes — the tools for doing that are quite crude, relatively speaking," Boeke said. Sometimes these cells get infected with a virus, and it completely shuts down drug production. A synthetic cell that lacked unnecessary genetic material could, evidence suggests, be virus-resistant, consistently producing useful drugs to treat disease. The results of GP-write could also lead to stem cell therapy that doesn't run the risk of infecting the patient with another disease, which appears to be what happened to one patient who received stem cell treatment in Mexico. Or they could create a line of microorganisms that could help humans generate some of their own amino acids — nutrients we usually get from food. These outcomes, of course, won't happen overnight. Boeke, who has spent years synthesizing yeast DNA, knows there will be plenty of technical hurdles. "Getting big pieces of DNA efficiently into mammalian cells, engineering them rapidly, these will be major challenges," he said. Scientists will also have to do that without breaking the bank. Right now, Kelley estimates that it costs 10 cents to synthesize every base pair, the bonded molecules that make up the double helix of DNA (start-up GenScript advertises even higher prices, at 23 cents for "economy"). Considering that humans have 3 billion base pairs. "If we can get that [cost] down to one cent per base pair, it would really make a difference," Kelley said. Since last May's meeting, Kelley, Boeke and their collaborators have published an article in Science about the project, as well as a white paper outlining its timeline. Close to 200 researchers and collaborators around the world have expressed interest in participating, Kelley says, ranging from institutional researchers to corporate scientists. Preliminary experiments are already underway, and the project organizers are discussing the project with companies as well as federal and state agencies that might help them reach their goal of raising $100 million this year. They estimate GP-write should cost less, in total, than the $3 billion Human Genome Project, though they have not provided more specific cost projections. It might not be so bad if these advances took some time. After news broke of the May meeting, some criticized the way the rollout was handled. "Given that human genome synthesis is a technology that can completely redefine the core of what now joins all of humanity together as a species, we argue that discussions of making such capacities real ... should not take place without open and advance consideration of whether it is morally right to proceed," read one op-ed, published in Cosmos. Boeke says a public and scientific discussion is exactly what the GP-write organizers intend to have. "I think articulation of our plan not to start right off synthesizing a full human genome tomorrow was helpful. We have a four- to five-year period where there can be plenty of time for debate about the wisdom of that, whether resources should be put in that direction or in another. Whenever it's human, everyone has an opinion and wants their voice to be heard. We want to hear what people have to say," Boeke said. Up to 250 people are expected at the New York Genome Center meeting, which will include discuss of applications, ethics and logistics behind the GP-write project. New technology that can help the 360 million people with hearing loss The race is on to stop a Zika virus epidemic in the US

News Article | December 21, 2016

Capio AB (publ) has signed an agreement to initially acquire 70% of the shares in CFR Hospitaler A/S "CFR" in Denmark. The CFR Group comprises four specialized hospitals and four radiology units with estimated net sales in 2016 of MDKK 280. The acquisition of CFR represents a new market entry for Capio, adding to the Group's Nordic home base and pan-European footprint for driving Modern Medicine and increased productivity in healthcare services. CFR operates four hospitals, of which two are located in the Copenhagen region, one is located in Odense on Fyn and one in Skørping, North Denmark (Nordjylland). The Copenhagen hospitals represent approximately 70% of the CFR Group's net sales. Specialized in orthopedics, spine surgery, gastrointestinal surgery, urology and ear-nose-throat disorders, CFR annually performs more than 80,000 consultations and 8,000 surgeries. In addition to the hospitals, CFR comprises four radiology units, one in each of the hospital facilities, offering MRI, mammography, ultrasound and X-ray diagnostic imaging. CFR is active in three out of five regions in Denmark. Thomas Kiær, the founder and former main owner of CFR will continue as CEO of CFR Group after the acquisition and will remain as a shareholder of CFR. "We are very pleased with the opportunity to acquire CFR Hospitaler, a well-established and professionally operated healthcare company. CFR matches Capio's core medical specialties and shares our fundamental view of delivering high quality healthcare. I am looking forward to further developing CFR together with Thomas Kiær, his management team and medical staff", says Thomas Berglund, President and CEO of Capio AB. "We are very happy and look forward to being a part of the Capio Group in the future. We are well-established in Denmark, and have focused on delivering healthcare of highest medical quality for a long time. Together with Capio, we see an opportunity to continue this development with a very experienced and strong partner with a long track record of delivering good quality healthcare in several European countries. As CEO of the company, I look forward to being part of an experienced and well-managed international group focusing on high quality healthcare", says Thomas Kiær, CEO of CFR. The Danish healthcare environment is similar to the one in Sweden and other Nordic countries, with a growing share of elderly population and increased GDP spend on healthcare. The market for healthcare in Denmark is estimated to be worth approximately BDKK 105, with a small private hospital share of 2%. Denmark has come far in Modern Medicine with a high share of day surgery and short AVLOS (Average Length Of Stay), but has availability challenges and productivity can be further improved. Hence, the outsourcing of public contracts is expected to gradually increase in line with the development in other Nordic countries. Enterprise value is MDKK 199 for 70% of CFR and Capio has the option to acquire the remaining 30% of the shares after two years. The acquisition is estimated to be closed and included in the Capio Group from January 2017. CFR is expected to have a positive impact on Capio's earnings during 2017. After the acquisition, Capio will have operations in five countries; Sweden, Denmark, Norway, France and Germany. The Danish operations will be included in the Nordic segment. This information is information that Capio AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 08:45 CET on December 21, 2016. This information was brought to you by Cision,c2154550 The following files are available for download:

News Article | February 6, 2016

Cristin O'Keefe Aptowicz is a New York Times best-selling nonfiction writer and poet, and the author of "Dr. Mütter's Marvels: A True Tale of Intrigue and Innovation at the Dawn of Modern Medicine" (Avery, 2014), which made seven national "Best Books of 2014" lists, including those from Amazon, The Onion's AV Club, NPR's Science Friday and The Guardian, among others. Aptowicz contributed this exclusive article to Live Science's Expert Voices: Op-Ed & Insights. The enormous arena was empty, save for the seesaws and the dozens of condemned criminals who sat naked upon them, hands tied behind their backs. Unfamiliar with the recently invented contraptions known as petaurua, the men tested the seesaws uneasily. One criminal would push off the ground and suddenly find himself 15 feet in the air while his partner on the other side of the seesaw descended swiftly to the ground. How strange. In the stands, tens of thousands of Roman citizens waited with half-bored curiosity to see what would happen next and whether it would be interesting enough to keep them in their seats until the next part of the "big show" began. With a flourish, trapdoors in the floor of the arena were opened, and lions, bears, wild boars and leopards rushed into the arena. The starved animals bounded toward the terrified criminals, who attempted to leap away from the beasts' snapping jaws. But as one helpless man flung himself upward and out of harm's way, his partner on the other side of the seesaw was sent crashing down into the seething mass of claws, teeth and fur. The crowd of Romans began to laugh at the dark antics before them. Soon, they were clapping and yelling, placing bets on which criminal would die first, which one would last longest and which one would ultimately be chosen by the largest lion, who was still prowling the outskirts of the arena's pure white sand. [See Photos of the Combat Sports Played in Ancient Rome] And with that, another "halftime show" of damnatio ad bestias succeeded in serving its purpose: to keep the jaded Roman population glued to their seats, to the delight of the event's scheming organizer. Welcome to the show The Roman Games were the Super Bowl Sundays of their time. They gave their ever-changing sponsors and organizers (known as editors) an enormously powerful platform to promote their views and philosophies to the widest spectrum of Romans. All of Rome came to the Games: rich and poor, men and women, children and the noble elite alike. They were all eager to witness the unique spectacles each new game promised its audience. To the editors, the Games represented power, money and opportunity. Politicians and aspiring noblemen spent unthinkable sums on the Games they sponsored in the hopes of swaying public opinion in their favor, courting votes, and/or disposing of any person or warring faction they wanted out of the way. The more extreme and fantastic the spectacles, the more popular the Games with the general public, and the more popular the Games, the more influence the editor could have. Because the Games could make or break the reputation of their organizers, editors planned every last detail meticulously. Thanks to films like "Ben-Hur" and "Gladiator," the two most popular elements of the Roman Games are well known even to this day: the chariot races and the gladiator fights. Other elements of the Roman Games have also translated into modern times without much change: theatrical plays put on by costumed actors, concerts with trained musicians, and parades of much-cared-for exotic animals from the city's private zoos. But much less discussed, and indeed largely forgotten, is the spectacle that kept the Roman audiences in their seats through the sweltering midafternoon heat: the blood-spattered halftime show known as damnatio ad bestias — literally "condemnation by beasts" — orchestrated by men known as the bestiarii. Super Bowl 242 B.C: How the Games Became So Brutal The cultural juggernaut known as the Roman Games began in 242 B.C., when two sons decided to celebrate their father's life by ordering slaves to battle each other to the death at his funeral. This new variation of ancient munera (a tribute to the dead) struck a chord within the developing republic. Soon, other members of the wealthy classes began to incorporate this type of slave fighting into their own munera. The practice evolved over time — with new formats, rules, specialized weapons, etc. — until the Roman Games as we now know them were born. In 189 B.C., a consul named M. Fulvius Nobilior decided to do something different. In addition to the gladiator duels that had become common, he introduced an animal act that would see humans fight both lions and panthers to the death. Big-game hunting was not a part of Roman culture; Romans only attacked large animals to protect themselves, their families or their crops. Nobilior realized that the spectacle of animals fighting humans would add a cheap and unique flourish to this fantastic new pastime. Nobilior aimed to make an impression, and he succeeded. [Photos: Gladiators of the Roman Empire] With the birth of the first "animal program," an uneasy milestone was achieved in the evolution of the Roman Games: the point at which a human being faced a snarling pack of starved beasts, and every laughing spectator in the crowd chanted for the big cats to win, the point at which the republic's obligation to make a man's death a fair or honorable one began to be outweighed by the entertainment value of watching him die. Twenty-two years later, in 167 B.C., Aemlilus Paullus would give Rome its first damnatio ad bestias when he rounded up army deserters and had them crushed, one by one, under the heavy feet of elephants. "The act was done publicly," historian Alison Futrell noted in her book "Blood in the Arena," "a harsh object lesson for those challenging Roman authority." The "satisfaction and relief" Romans would feel watching someone considered lower than themselves be thrown to the beasts would become, as historian Garrett G. Fagan noted in his book "The Lure of the Arena," a "central … facet of the experience [of the Roman Games. … a feeling of shared empowerment and validation … " In those moments, Rome began the transition into the self-indulgent decadence that would come to define all that we associate with the great society's demise. General Julius Caesar proved to be the first true maestro of the Games. He understood how these events could be manipulated to inspire fear, loyalty and patriotism, and began to stage the Games in new and ingenious ways. For example, Caesar was the first to arrange fights between recently captured armies, gaining firsthand knowledge of the fighting techniques used by these conquered people and providing him with powerful insights to aid future Roman conquests, all the while demonstrating the republic's own superiority to the roaring crowd of Romans. After all, what other city was powerful enough to command foreign armies to fight each other to the death, solely for their viewing pleasure? Caesar used exotic animals from newly conquered territories to educate Romans about the empire's expansion. In one of his games, "Animals for Show and Pleasure in Ancient Rome" author George Jennison notes that Caesar orchestrated "a hunt of four hundred lions, fights between elephants and infantry … [and] bull fighting by mounted Thessalians." Later, the first-ever giraffes seen in Rome arrived — a gift to Caesar himself from a love-struck Cleopatra. To execute his very specific visions, Caesar relied heavily on the bestiarii — men who were paid to house, manage, breed, train and sometimes fight the bizarre menagerie of animals collected for the Games. Managing and training this ever-changing influx of beasts was not an easy task for the bestiarii. Wild animals are born with a natural hesitancy, and without training, they would usually cower and hide when forced into the arena's center. For example, it is not a natural instinct for a lion to attack and eat a human being, let alone to do so in front of a crowd of 100,000 screaming Roman men, women and children! And yet, in Rome's ever-more-violent culture, disappointing an editor would spell certain death for the low-ranking bestiarii. To avoid being executed themselves, bestiarii met the challenge. They developed detailed training regimens to ensure their animals would act as requested, feeding arena-born animals a diet compromised solely of human flesh, breeding their best animals, and allowing their weaker and smaller stock to be killed in the arena. Bestiarii even went so far as to instruct condemned men and women on how to behave in the ring to guarantee a quick death for themselves — and a better show. The bestiarii could leave nothing to chance. As their reputations grew, bestiarii were given the power to independently devise new and even more audacious spectacles for the ludi meridiani (midday executions). And by the time the Roman Games had grown popular enough to fill 250,000-seat arenas, the work of the bestiarii had become a twisted art form. As the Roman Empire grew, so did the ambition and arrogance of its leaders. And the more arrogant, egotistic and unhinged the leader in power, the more spectacular the Games would become. Who better than the bestiarii to aid these despots in taking their version of the Roman Games to new, ever-more grotesque heights? Animal spectacles became bigger, more elaborate, and more flamboyantly cruel. Damnatio ad bestias became the preferred method of executing criminals and enemies alike. So important where the bestiarii's contribution, that when butcher meat became prohibitively expensive, Emperor Caligula ordered that all of Rome's prisoners "be devoured" by the bestiarii's packs of starving animals. In his masterwork De Vita Caesarum, Roman historian Gaius Suetonius Tranquillus (b. 69 A.D.) tells of how Caligula sentenced the men to death "without examining the charges" to see if death was a fitting punishment, but rather by "merely taking his place in the middle of a colonnade, he bade them be led away 'from baldhead to baldhead,'"(It should also be noted that Caligula used the funds originally earmarked for feeding the animals and the prisoners to construct temples he was building in his own honor!) To meet this ever-growing pressure to keep the Roman crowds happy and engaged by bloodshed, bestiarii were forced to consistently invent new ways to kill. They devised elaborate contraptions and platforms to give prisoners the illusion they could save themselves — only to have the structures collapse at the worst possible moments, dropping the condemned into a waiting pack of starved animals. Prisoners were tied to boxes, lashed to stakes, wheeled out on dollies and nailed to crosses, and then, prior to the animals' release, the action was paused so that bets could be made in the crowd about which of the helpless men would be devoured first. Perhaps most popular — as well as the most difficult to pull off — were the re-creations of death scenes from famous myths and legends. A single bestiarius might spend months training an eagle in the art of removing a thrashing man's organs (a la the myth of Prometheus). The halftime show of damnatio ad bestias became so notorious that it was common for prisoners to attempt suicide to avoid facing the horrors they knew awaited them. Roman philosopher and statesmen Seneca recorded a story of a German prisoner who, rather than be killed in a bestiarius' show, killed himself by forcing a communally used prison lavatory sponge down his throat. One prisoner who refused to walk into the arena was placed on a cart and wheeled in; the prisoner thrust his own head between the spokes of its wheels, preferring to break his own neck than to face whatever horrors the bestiarius had planned for him. It is in this era that Rome saw the rise of its most famous bestiarius, Carpophorus, "The King of the Beasts." Carpophorus was celebrated not only for training the animals that were set upon the enemies, criminals and Christians of Rome, but also for famously taking to the center of the arena to battle the most fearsome creatures himself. He triumphed in one match that pitted him against a bear, a lion and a leopard, all of which were released to attack him at once. Another time, he killed 20 separate animals in one battle, using only his bare hands as weapons. His power over animals was so unmatched that the poet Martial wrote odes to Carpophorus. "If the ages of old, Caesar, in which a barbarous earth brought forth wild monsters, had produced Carpophorus," he wrote in his best known work, Epigrams. "Marathon would not have feared her bull, nor leafy Nemea her lion, nor Arcadians the boar of Maenalus. When he armed his hands, the Hydra would have met a single death; one stroke of his would have sufficed for the entire Chimaera. He could yoke the fire-bearing bulls without the Colchian; he could conquer both the beasts of Pasiphae. If the ancient tale of the sea monster were recalled, he would release Hesione and Andromeda single-handed. Let the glory of Hercules' achievement be numbered: it is more to have subdued twice ten wild beasts at one time." To have his work compared so fawningly to battles with some of Rome’s most notorious mythological beast sheds some light on the astounding work Carpophorus was doing within the arena, but he gained fame as well for his animal work behind the scenes. Perhaps most shockingly, it was said that he was among the few bestiarii who could command animals to rape human beings, including bulls, zebras, stallions, wild boars and giraffes, among others. This crowd-pleasing trick allowed his editors to create ludi meridiani that could not only combine sex and death but also claim to be honoring the god Zeus. After all, in Roman mythology, Zeus took many animal forms to have his way with human women. Historians still debate how common of an occurrence public bestiality was at the Roman Games — and especially whether forced bestiality was used as a form of execution — but poets and artists of the time wrote and painted about the spectacle with a shocked awe. "Believe that Pasiphae coupled with the Dictaean bull!" Martial wrote. "We've seen it! The Ancient Myth has been confirmed! Hoary antiquity, Caesar, should not marvel at itself: whatever Fame sings of, the arena presents to you." The Roman Games and the work of the bestiarii may have reached their apex during the reign of Emperor Commodus, which began in 180 AD. By that time, the relationship between the emperors and the Senate had disintegrated to a point of near-complete dysfunction. The wealthy, powerful and spoiled emperors began acting out in such debauched and deluded ways that even the working class "plebs" of Rome were unnerved. But even in this heightened environment, Commodus served as an extreme. Having little interest in running the empire, he left most of the day-to-day decisions to a prefect, while Commodus himself indulged in living a very public life of debauchery. His harem contained 300 girls and 300 boys (some of whom it was said had so bewitched the emperor as he passed them on the street that he felt compelled to order their kidnapping). But if there was one thing that commanded Commodus' obsession above all else, it was the Roman Games. He didn't just want to put on the greatest Games in the history of Rome; he wanted to be the star of them, too. Commodus began to fight as a gladiator. Sometimes, he arrived dressed in lion pelts, to evoke Roman hero Hercules; other times, he entered the ring absolutely naked to fight his opponents. To ensure a victory, Commodus only fought amputees and wounded soldiers (all of whom were given only flimsy wooden weapons to defend themselves). In one dramatic case recorded in Scriptores Historiae Augustae, Commodus ordered that all people missing their feet be gathered from the Roman streets and be brought to the arena, where he commanded that they be tethered together in the rough shape of a human body. Commodus then entered the arena's center ring, and clubbed the entire group to death, before announcing proudly that he had killed a giant. But being a gladiator wasn't enough for him. Commodus wanted to rule the halftime show as well, so he set about creating a spectacle that would feature him as a great bestiarius. He not only killed numerous animals — including lions, elephants, ostriches and giraffes, among others, all of which had to be tethered or injured to ensure the emperor's success — but also killed bestiarii whom he felt were rivals (including Julius Alexander, a bestiarius who had grown beloved in Rome for his ability to kill an untethered lion with a javelin from horseback). Commodus once made all of Rome sit and watch in the blazing midday sun as he killed 100 bears in a row — and then made the city pay him 1 millions esterces (ancient Roman coins) for the (unsolicited) favor. By the time Commodus demanded the city of Rome be renamed Colonia Commodiana ("City of Commodus") — Scriptores Historiae Augustae, noted that not only did the Senate "pass this resolution, but … at the same time [gave] Commodus the name Hercules, and [called] him a god" — a conspiracy was already afoot to kill the mad leader. A motley crew of assassins — including his court chamberlain, Commodus' favorite concubine, and "an athlete called Narcissus, who was employed as Commodus' wrestling partner" — joined forces to kill him and end his unhinged reign. His death was supposed to restore balance and rationality to Rome — but it didn't. By then, Rome was broken — bloody, chaotic and unable to stop its death spiral. In an ultimate irony, reformers who stood up to oppose the culture's violent and debauched disorder were often punished by death at the hands of the bestiarii, their deaths cheered on by the very same Romans whom they were trying to protect and save from destruction. The Death of the Games and the Rise of Christianity As the Roman Empire declined, so did the size, scope and brutality of its Games. However, it seems fitting that one of the most powerful seeds of the empire's downfall could be found within its ultimate sign of contempt and power — the halftime show of damnatio ad bestias. Early Christians were among the most popular victims in ludi meridiani. The emperors who condemned these men, women and children to public death by beasts did so with the obvious hope that the spectacle would be so horrifying and humiliating that it would discourage any other Romans from converting to Christianity. Little did they realize that the tales of brave Christians facing certain death with grace, power and humility made them some of the earliest martyr stories. Nor could they have imagined that these oft-repeated narratives would then serve as invaluable tools to drive more people toward the Christian faith for centuries to come. In the end, who could have ever imagined that these near-forgotten "halftime shows" might prove to have a more lasting impact on the world than the gladiators and chariot races that had overshadowed the bestiarii for their entire existence? Read more from Aptowicz in her Expert Voices essay, "Surgery in a Time Before Anesthesia." Follow all of the Expert Voices issues and debates — and become part of the discussion — on Facebook, Twitter and Google+. The views expressed are those of the author and do not necessarily reflect the views of the publisher. This version of the article was originally published on Live Science. Copyright 2016 LiveScience, a Purch company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Qi H.,Chinese University of Hong Kong | Han Y.,Modern Medicine | Rong J.,Chinese University of Hong Kong
Neuropharmacology | Year: 2012

Many phytochemicals may ameliorate neurological disorders through a hormetic mechanism. The aim of this study was to characterize the hormetic role of Z-ligustilide in PC12 cells against oxygen glucose deprivation (OGD) induced cell death. We examined the interactions of Z-ligustilide with the pro-survival signals mediated by phosphatidylinositol 3-kinase (PI3K) and transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) pathways. We also investigated the effect of Z-ligustilide on the intracellular redox signaling system involving reactive oxygen species (ROS) and glutathione (GSH). Z-ligustilide not only triggered stress response by causing ROS formation and transient GSH depletion, but also activated survival-promoting signals via cross-talking of PI3K and Nrf2 pathways. A key finding was that Z-ligustilide preconditioning protected PC12 cells from OGD-induced injury either at a low concentration for a prolonged period of time or at a high concentration for a short period of time. Presumably, mild preconditioning stimulated moderate ROS production, but effectively activated hormetic signals and induced stress responsive genes. In contrast, higher concentrations of Z-ligustilide could be toxic over a prolonged period of time due to massive ROS production. These results suggest that the effect of Z-ligustilide may be regulated by a biphasic hormetic mechanism involving initial induction of oxidative stress and subsequent activation of stress response gene expression. © 2011 Elsevier Ltd. All rights reserved.

News Article | February 15, 2017

ROSELAND, N.J. — Author Patrick J. Conte, MD, PhD has pondered this question, “Is there a reason why we were born, and do we all have a purpose in life?” In his book, “Mysteries of Life, Death and Beyond” (published by Balboa Press), he attempts to answer it and hopefully guide readers on an amazing and somewhat mystical journey. He takes them from the creation of the known universe and through the time – space continuum of evolution, the effects of karmic interferences, the theory of reincarnation and the development and expressions of one’s emotional psyche. He accompanies them through the progression of the seven major energy centers of the body called chakras, which are in essence guide posts with instructions that help provide physical and spiritual fulfillment in order that they may enjoy all the wonderful experiences in this life and spiritual bliss in the next. “I believe that people are falling away from their religious beliefs and floundering around in seeking God or some higher power. People need to find out for themselves how to find their path in life. They need to be shown a roadmap so that they can find out for themselves how to live their lives and why,” Conte says. An enlightening and insightful read, “Mysteries of Life, Death and Beyond” will give readers a better understanding on where they came from and for what purpose. It will also help them get answers about matters concerning faith and assist people into finding their true spiritual self and what this life is all about. “Mysteries of Life, Death and Beyond” By Patrick J. Conte, MD, PhD Hardcover | 6x9in | 406 pages | ISBN 9781504359610 Softcover | 6x9in | 406 pages | ISBN 9781504359603 E-Book | 406 pages | ISBN 9781504360371 Available at Amazon and Barnes & Noble About the Author After graduating high school, Patrick J. Conte, MD, PhD attended the American Academy of Mortuary Science in New York City. Upon graduation, he was bestowed the Dean’s award. He was accepted into Stritch School of Medicine of Loyola University in Chicago, upon mustering out of active duty and without having to complete his fourth year of pre-med at Seton Hall. He is certified by the American Board of General Radiology, the American Board of Nuclear Medicine and the American Board of Diagnostic Radiology with Special Competence in Nuclear Radiology. He has been in practice for more than 40 years, and currently the Chief of Nuclear Medicine and senior attending radiologist at St. Joseph Regional Medical Center, Paterson. He is also the author of “Converging Paths of Ancient Ayurveda” and “Modern Medicine, A Western Physician’s Perspective.” For more information, interested parties may log on to Balboa Press, a division of Hay House, Inc. – a leading provider in publishing products that specialize in self-help and the mind, body, and spirit genres. Through an alliance with indie book publishing leader Author Solutions, LLC, authors benefit from the leadership of Hay House Publishing and the speed-to-market advantages of the self-publishing model. For more information, visit To start publishing your book with Balboa Press, call 877-407-4847 today. For the latest, follow @balboapress on Twitter. ###

Chang X.,Modern Medicine | Fang K.,Modern Medicine
Cancer Cell International | Year: 2010

PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expression of PADI4 in various malignant tumour tissues. PADI4 is also expressed at high levels in the blood of patients with some malignant tumours. Thus far, citrullination of histone, cytokeratin, antithrombin and fibronectin have been confirmed to be involved in abnormal apoptosis, high coagulation, and disordered cell proliferation and differentiation, all of which are main features of malignant tumours. PADI4 is expressed in CD34+ stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. These findings suggest that PADI4 may play an important role in tumourigenesis. © 2010 Chang and Fang; licensee BioMed Central Ltd.

Shokri H.,Modern Medicine
Journal de Mycologie Medicale | Year: 2014

Objective: To investigate the DNA fingerprinting of Candida zeylanoides (C.zeylanoides) strains and the correlation between genotyping and antifungal susceptibility of C.zeylanoides. Methods: Paper discs containing nystatin, ketoconazole, fluconazole, Zataria multiflora (Z.multiflora) and Pulicaria gnaphalodes (P.gnaphalodes) essential oils were used in the disc diffusion method to evaluate the in vitro activity of the antifungal agents by measuring the mean diameter of inhibition around the discs. Yeast isolates were characterized by randomly amplified polymorphic DNA (RAPD) analysis using two different primers. Results: The mean inhibition zones were calculated 36.1. ±. 2.2. mm for ketoconazole, 25.3. ±. 2.0. mm for nystatin and 14.9. ±. 1.4. mm for fluconazole. Z.multiflora essential oil revealed a 58.6. ±. 2.6. mm mean zone of inhibition while P.gnaphalodes showed a 36.7. ±. 1.8. mm zone of inhibition against all isolates tested. A total of 14 strains of C.zeylanoides were divided into three types, 1 was genotype A strain, 2 genotype B strains and 11 genotype C strains. Strain of genotype A was significantly more susceptible to ketoconazole and nystatin than fluconazole (P<. 0.05). Strains of genotype B were more susceptible to ketoconazole than other antifungal agents (P>. 0.05). Strains of genotype C were significantly more susceptible to ketoconazole than fluconazole and nystatin (P<. 0.05). There was a significant correlation between C.zeylanoides genotypes and antifungal susceptibility (P<. 0.05). Conclusion: We concluded that all C.zeylanoides genotypes were susceptible to nystatin and Z.multiflora essential oil. The correlation between antifungal susceptibility and C.zeylanoides genotype may be of potential therapeutic significance and larger studies are needed to prove this finding. © 2014 Elsevier Masson SAS.

Shen H.,Modern Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2011

To established an HPLC-MS assay to determine aconitine, mesaconitine and hypaconitine simultaneously in rat plasma and be used to investigate the pharmacokinetics of the three alkaloids. Three groups of rats were orally administered respectively with three decoctions including decoction of Radix Aconiti Laterlis, blend decoction of Radix Aconiti Laterlis and Radix Glycyrrhizae which decocted separately, decoction of Radix Aconiti Laterlis and Radix Glycyrrhizae which decocted together,the dosage of Radix Aconiti Laterlis was 1.5 g/kg. The contents of aconitine, mesaconitine and hypaconitine in rat plasma were detected using a liquid Chromatography-electrospray ionization/tandem mass spectrometry method. Pharmacokinetic parameters were estimated using DAS 2.0. The pharmacokinetic parameters of the three compounds obtained showed that Cmax and AUC of aconitine, mesaconitine and hypaconitine were decreased. MRT, t1/2 were prolonged and there was no obviously change in Tmax when Radix Aconiti Lateralis was combined with Radix Glycyrrhizae. The effect of decoction which decocted together was more prominent than which decocted separately. There are obvious effects on pharmacokinetic of Aconitine, Mesaconitine and Hypaconitine in Rat Plasma when Radix Aconiti Laterlis is combined with Radix Glycyrrhizae.

A usage of the extracts from polysaccharide of Ophiopogon japonicus in the preparation of food additives, health products or pharmaceutical products.

News Article | July 21, 2015

· Net sales was MSEK 3,441 (3,357). Organic sales growth was 3.5% (4.1) and total sales growth was 2.5% (6.9) · Operating result (EBITDA) was MSEK 237 (223)1 with an operating margin of 6.9% (6.7)1. EBITDA increased by 6.3% on an adjusted basis · Operating result (EBITA) was MSEK 136 (115)1 with an operating margin of 4.0% (3.5)1. EBITA increased by 18.3% on an adjusted basis · Earnings per share SEK -0.25 (0.50)2 and adjusted earnings per share SEK 0.47 (0.28)2 · Net sales was MSEK 6,919 (6,728). Organic sales growth was 3.2% (4.4) and total sales growth was 2.8% (6.7) · Operating result (EBITDA) was MSEK 528 (495)1 with an operating margin of 7.6% (7.4)1. EBITDA increased by 6.7% on an adjusted basis · Operating result (EBITA) was MSEK 327 (284)1 with an operating margin of 4.7% (4.2)1. EBITA increased by 15.1% on an adjusted basis · Earnings per share SEK 0.33 (0.86)2 and adjusted earnings per share SEK 1.22 (0.93)2 1 For reported numbers for 2014 refer to page 4. Refer to page 27 for definitions of EBITDA and EBITA. 2 Earnings per share and adjusted earnings per share before and after dilution. Refer to note 2 for calculations of earnings per share. “Our medical strategy continues to deliver stable improvements in sales growth and operating results in all segments.” We have a clear strategy and focus: In continental Europe, Modern Medicine is driving Rapid Recovery with shorter treatment times and a higher proportion of outpatient treat-ments. In the Nordics, Modern Management will increase the direct patient time for medical staff thus driving higher productivity through empowered people. In financial terms this translates for the Group into 3.2% organic sales growth in the first six months (3.5% in the quarter) and an improvement in adjusted operating result (EBITA) of 15.1% (18.3% in the quarter). In the Nordics the focus is on more patient time for doctors and nurses through less administrative duties. Several projects will be implemented during 2015 to speed up this development. Organic sales growth was for the first six months 5.1% (4.8% in the quarter) and adjusted operating result (EBITA) was up 21.1% (17.2% in the quarter). There was good sales growth and positive development of operating results in Capio St Göran’s hospital, Specialist Clinics and Norway. Proximity Care has limited growth and no result improvements and thus has struggled to outperform last year. In order to improve the development in Proximity Care, there is a very strong focus on increasing the time for patients through more doctor visits per day among other actions. In France the number of patients operated on increased by 2.1%, including 6.6% outpatient growth and a -6.2% inpatient decrease in the first six months. This means that we are successful in Rapid Recovery moving patients from in- to outpatient treatments in line with our strategy. The share of outpatients operated on has increased by 3 p.p. to 67% out of the total number of patients operated on in the first six months compared to last year. We have also seen the average length of stay (AVLOS) continuing to shorten. During the first half of 2015 we have performed in total 3,465 (3,287) hip and knee replacements, of which 226 (34) in day surgery. With the French Government’s ambition to push for shorter stays and more outpatient treatments, prices have been decreased from March 1, 2015 with a negative effect on prices with -2.5%. The organic sales growth of 1.2% (1.8% in the quarter) includes the effect of the price reduction as well as the effect from a doctors’ strike, opposing new regulation, in January in certain hospitals. Capio France has put a program in place to speed up implementation of Modern Medicine to compensate for this price decrease. The program is not yet fully up to speed. However, considering the lower prices from March and the doctors’ strike effect in January the result development is positive in the first six months. In Germany the organic sales growth was 1.1% (2.6% in the quarter) and operating result (EBITA) was up with 11.1%, reflecting an improved performance in the general hospitals (mainly the hospital in Dannenberg). This is the first financial report made public after the listing of Capio on Nasdaq Stockholm on June 30, 2015. Through the listing, Capio gains long term ownership, further increased transparency and access to capital for expansion. A new era starts for Capio with the long term ambition to further contribute to the renewal of European healthcare implementing Modern Medicine and Modern Management. Investors, analysts and media are invited to participate in a telephone conference on July 21, 2015 at 9.30 am (CET). President and CEO Thomas Berglund and CFO Olof Bengtsson will present the report and answer questions. The telephone conference will be audio casted live on To participate in the telephone conference, please register at and dial in five minutes prior to the start of the conference call. Prior to the start of the telephone conference, presentation slides will be available at A recorded version of the audio cast will be available at during the afternoon (CET). For further information regarding Capio’s IR activities, refer to ( Capio AB (publ) discloses the information provided herein pursuant to the Securities Markets Act and/or the Financial Instruments Trading Act. The information was submitted for publication at 08.00 (CET) on July 21, 2015. Capio AB (publ) is a leading, pan-European healthcare provider offering a broad range of high quality medical, surgical and psychiatric healthcare services in four countries through its hospitals, specialist clinics and primary care units. In 2014, Capio’s 12,357 employees provided healthcare services during 4.6 million patient visits across the Group’s facilities in Sweden, Norway, France and Germany, generating net sales of MSEK 13,200. Capio operates across three geographic segments: Nordic (54 percent of Group net sales 2014), France (37 percent of Group net sales 2014) and Germany (9 percent of Group net sales 2014). For more information about Capio, please see This information was brought to you by Cision

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