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Lopez Lopez D.,Health and Podiatry Unit | Vilar Fernandez J.M.,Modeling | Alvarez Castro C.,Health and Podiatry Unit | Romero Morales C.,Exercise And Sporteuropean University Of Madridvillaviciosa Of Odon | And 2 more authors.
Dermatologic Therapy | Year: 2016

The aim of our study was to evaluate the efficacy and safety of topical cantharidin-podophylotoxin-salicylic acid (CPS) treatment of recalcitrant plantar warts (RPW). This study was carried out in a health center in the city of A Coruña (Spain) between January and December 2013. A total of 75 patients completed all the stages of the research process. Information related to treatment with CPS and adverse effects was abstracted from medical records. Of 93 potential patients identified, 75 had at least one follow-up visit or telephone call after treatment and were included in this study. Patients experienced an average of 5.4 visits until complete resolution of their plantar wart occurred, although CPS was not applied at every visit. Fifty-four patients required one application to eliminate the wart and 21 patients required two applications/patient. Seventy-seven percent of patients experienced blistering - an expected therapeutic side effect. All patients experienced some form of an adverse event, the most common being pain (81.3%) and significant blistering (15%). Other side effects were rare (18.7%) and included pruritus, possible mild infection, significant irritation, and bleeding. All patients reported treatment, supporting our results that CPS is a safe and efficacious treatment modality for RPW and should be considered when symptomatic infection necessitates treatment. © 2016 Wiley Periodicals, Inc.

Strub G.,French German Research Institute of Saint Louis | Basset M.,Modeling
2016 AIAA Guidance, Navigation, and Control Conference | Year: 2016

This article investigates the design and validation of a skid-to-turn autopilot for an ex- perimental canard-guided, fin-stabilized 80mm guided projectile prototype in a Hardware- In-the-Loop wind tunnel-based setup. The projectile dynamics are a priori unknown and are determined from open-loop system identification experiments conducted on the test setup. To this end, a nonlinear airframe model is discussed and considered for lineariza- tion around equilibrium operating points. The obtained linear model structure is then assessed for identifiability and several data-collection experiments are conducted, resulting in a family of linear models. This knowledge is leveraged in a second step to compute a robustly stable multi-objective disturbance and reference tracking controller, which is then implemented on the HIL test setup. Autopilot time-domain performance is finally assessed by the means of numerical simulations and experimental results gathered from the test setup, demonstrating the excellent suitability of the proposed approach. © 2016, American Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

Baldino N.,Modeling | Gabriele D.,University of Calabria | Lupi F.R.,Modeling | Seta L.,Modeling | Zinno R.,Modeling
Cement and Concrete Research | Year: 2014

New generation concretes have specific properties, often obtained by using additives, and these properties are strongly affected by rheological characteristics of the fresh cement paste. In this work small amplitude oscillations were adopted to investigate the effects of synthetic zeolite, limestone and silica fume on the rheological properties of fresh pastes. Time sweep tests were used to describe paste evolution with time evidencing that zeolite is more able to increase the rate of structure development with respect to other additives. Frequency sweep tests evidenced that zeolite, at least at low concentration, is able to improve the mechanical strength and to increase the liquid-like behaviour of the paste. Adopted rheological tests and data analysis are suitable to describe paste structure and evolution with time and synthetic zeolite seems able to give better properties to cement paste than other additives can. © 2014 Elsevier Ltd.

Aras R.,Modeling | Shen Y.,Modeling | Audette M.,Modeling
Advances in Engineering Software | Year: 2016

For surgical simulation applications, realistic behavioral modeling of soft tissue is considered to be one of the most significant challenges, because biomechanical soft-tissue models need to reflect the correct elastic response, be efficient in order to run at interactive simulation rates, and be able to support operations such as cuts and sutures. For these reasons, having a usable 3D cutting engine is a significant feature for interactive surgery simulation software. Mesh-based solutions, where the connections between the individual degrees of freedom (DoF) are defined explicitly, have been the traditional approach to soft-tissue biomechanics. However, when the problem under investigation in interactive biomechanics contains a simulated surgical gesture that entails a cut that disrupts the connectivity, the underlying mesh structure has to undergo remeshing operation, and most of the time it causes the performance bottleneck in the simulation. Unlike the tightly-coupled nonoverlapping element composition of the mesh-based solutions, this paper builds an analytic enrichment function on top of a loosely-coupled meshless method for constitutive modeling of elastic soft tissues, where arbitrary discontinuities or cuts are applied to the objects in the context of surgical simulation. Enrichment values for a continuous cut interface are computed and stored inside a grid structure that is accessed by individual meshless nodes in order to update their weight functions. The presented analytic enrichment function is efficient to compute and easy to integrate into existing meshless models. The meshless mechanics code and the enrichment-based cut handling functionalities have been implemented within the open-source simulation framework SOFA. © 2016 Elsevier Ltd

Fazio P.,Modeling | Santamaria A.F.,Modeling
Advances in Electrical and Electronic Engineering | Year: 2015

In this work, a performance study of a system equipped with a transparent Gap Filler solution in a DVB-RCS2 satellite platform has been provided. In particular, a simulation model based on a 3-state Markov chain, overcoming the blockage status through the introduction of a transparent Gap Filler (using devices on both tunnel sides) has been implemented. The handover time, due to switching mechanism between satellite and Gap Filler, has been taken into account. As reference scenario, the railway market has been considered, which is characterized by a N-LOS condition, due to service disruptions caused by tunnels, vegetation and buildings. The system performance, in terms of end-to-end delay, queue size and packet loss percentage, have been evaluated, in order to prove the goodness of communications in a real railroad path. © 2015 ADVANCES IN ELECTRICAL AND ELECTRONIC ENGINEERING.

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