MNR Medical College

andhra Pradesh, India

MNR Medical College

andhra Pradesh, India
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Prasad V.S.,MNR Medical College
Journal of Ethnopharmacology | Year: 2010

Ethnopharmacological relevance: The aerial parts of Coccinia cordifolia L. are used to treat female infertility in West Bengal state of India. Aim of the study: The present study was undertaken to evaluate the fertility inducing effect of aerial parts of Coccinia cordifolia L. in female rats. Materials and methods: The effect of aqueous extract of Coccinia cordifolia L. on hyperprolactinemia induced infertility, endometriosis induced infertility and androgen-induced infertility was studied. The effect on serum estrogen level, serum progesterone level and reproductive tract was also evaluated in normal healthy female rats. The extract was administered orally at two different doses of 500 mg/kg and 1000 mg/kg. Results: In hyperprolactinemia induced infertility model, the numbers of uterine implants were almost 10 times more in the extract treated groups as compared to control. The high dose of extract also produced a significant increase in serum estrogen levels (p < 0.01) and number of corpus luteum (p < 0.05) in healthy female rats. The extract at both doses was effective in reducing the weight of endometrial implants by 70-80%, but failed to induce fertility in rats with endometriosis. The extract was ineffective in inducing fertility in androgen-induced infertility model. Conclusions: The aqueous extract of Coccinia cordifolia L. induces fertility in hyperprolactinemia induced infertility model in female rats. © 2009 Elsevier Ireland Ltd. All rights reserved.

Devaraj V.C.,Bioneeds Pre Clinical services | Satya Prasad V.,MNR Medical College | Vinay Babu S.N.,Bioneeds Pre Clinical services
Saudi Pharmaceutical Journal | Year: 2011

Raphinus sativus Linn (Cruciferae) commonly known as 'Radish' is a multipurpose herb cultivated in different parts of the world for its edible roots and leaves. The present study was aimed to evaluate the antiulcer activity of leaf extracts of R. sativus Linn on acetic acid induced chronic gastric ulcer and pylorus ligation induced gastric ulcer in rats. The acute oral toxicity study revealed that all the extracts were safe up to 2000. mg/kg per oral dose; hence one-tenth of this dose was selected for evaluation of antiulcer activity. In acetic acid induced gastric ulcer models, the ERS, CRS, EARS and AQRS have offered significant protection against acetic acid induced ulcers when compared to control group. While in pylorus ligation induced ulcer model the ERS, EARS and AQRS showed significant protection by decreasing the ulcer index, total acidity and free acidity. In conclusion the leaf extracts of R. sativus Linn are found to possess antiulcer property in the experimental animal models of gastric ulcers, which is consistent with the literature report in the folk medicine. © 2011.

Amane H.S.,SDM Medical College and Hospital | Burte N.P.,Mnr Medical College
Indian Journal of Pharmacology | Year: 2011

Objective: To compare the efficacy and safety profile of dalteparin, a low-molecular-weight heparin with a standard unfractionated heparin in patients with unstable angina pectoris. Materials and Methods: This was a 6-month, prospective, parallel, randomized and open-labeled study. Patients of angina pectoris were randomized to receive either unfractionated heparin or dalteparin for 5 days. They were followed for 21 days during three visits on 1 st, 5 th and 21 st days. A series of resting electrocardiogram were undertaken in all patients on each visit. Results: The frequency of the combined clinical outcome of death, myocardial infarction and recurrence of angina was similar during 21 days of follow-up with either dalteparin or intravenous unfractionated heparin. In patients who received dalteparin 2.43% patients developed minor bleeding in the form of epistaxis and 2.5% patients who received unfractionated heparin developed minor bleeding in the form of macroscopic hematuria. Conclusion: Dalteparin is as effective and safe as unfractionated heparin in the treatment of unstable angina. Dalteparin does not require routine laboratory monitoring as with unfractionated heparin.

Mukhopadhyay B.K.,MNR Medical College
World Journal of Laparoscopic Surgery | Year: 2012

Laparoscopic surgery is a less painful surgery to patients but is more for the doctor. Surgeons feels fatigue and discomfort due to its technical complexity and ergonomics. Prolong duration of surgery and pneumoperitoneum creates the patient exhausted and causes some remarkable hemodynamic changes. During operation the strategic rest break after 90 minutes, for 5 minutes, increase the better outcome not only to patients but also to the doctor.

Patil T.B.,MNR Medical College | Paithankar M.M.,Government Medical College
Annals of Tropical Medicine and Public Health | Year: 2012

Aims: This study was aimed to study the clinical and radiological profile of neurocysticercosis and outcomes of treatment in neurocysticercosis. Settings and Design: A prospective observational study in a tertiary care hospital. Methods and Material: A total of 40 patients coming under definitive or probable diagnosis of neurocysticercosis as per the revised diagnostic criteria for neurocysticercosis were included in this study. Clinical history, physical examination, and neuroimaging (CT or MRI) studies were done at the beginning. Patients were treated with albendazole, corticosteroids, and antiepileptic drugs. They were followed up clinically for 3 months and neuroimaging study was repeated 3 months after albendazole therapy. Results: Definitive cases were 28 (70%) and probable cases were 12 (30%). Male: female ratio was 2.07. Mean age of 29.62 9.08 years. The commonest presentation was seizures in 38 (95%). Twenty-nine (72.5%) patients had a single lesion and 11 (27.5%) had multiple lesions in initial imaging study. Commonest site of lesion was parietal lobe (45%). Most common stage of presentation was colloidal (55%). Thirty-seven (92.5%) patients were free of seizures at the end of three months. At the end of 3 months, 23 (57.5%) patients had radiological resolution (Complete resolution + partial resolution + calcification). Conclusions: Neurocysticercosis usually affects young persons, mostly in third decade, being equally common among vegetarians. Most common clinical manifestation is seizures. Single lesion is more common than multiple lesions, commonly presenting in colloidal. Clinical and radiological response to 4-week therapy with albendazole is quite satisfactory. All cases of young-and adult-onset epilepsy in tropical countries should be investigated for neurocysticercosis.

A study was conducted to assess the visual outcomes of patients after cataract surgery with intraocular lens implants with reference to visual acuity (VA) and visual function (VF) and to assess patient satisfaction with surgical outcome. The retrospective study was carried out using operation theatre records at the Rural Health Training Centre (RHTC), Paithan, during 2007. Out of 819 cataract surgery patients operated in 2007 a total of 50 were selected randomly. Door-to-door visits were paid by investigator and multipurpose worker to previously operated patients for VA examination and to fill predesigned questionnaire. Statistical analysis was done by using SPSS 17.0 Version; 50% patients had VA in fair vision range of <6/18-6/60 and 52% showed the VF in the range of 76-100. Of the 32 satisfied patients, majority were in the age group 70-79 years. The patients with good visual outcomes achieved after surgery would act as pamphlets for the community.

Mohammad A.,MNR Medical College | Nagaiah G.,MNR Medical College | Akshay S.,MNR Medical College | Jitendra,MNR Medical College
Indian Journal of Community Health | Year: 2015

Introduction: Micronutrients play a very important role in both promoting health and curing disease by health professionals. They play a central part in metabolism and in the maintenance of tissue function. It is important that doctors and other health professionals are aware of the evidence for the nutritional essentiality of these substances, and for the situations where an increased intake may lead to clinical benefit. Objectives: 1. To assess the knowledge of health professionals micronutrients and practices in prescribing in treatment. 2. To determine the measures followed by the health professionals in including micronutrients in their own diet. Materials and Methods: A pre-designed and pre-tested anonymous self administered questionnaire was used in a cross sectional study. Results: 70% of doctors said that they had enough knowledge about prescribing and counseling to patients regarding micronutrients. On comparing the knowledge of specialists about micronutrients with the general practitioners we didn’t find any significant increase in knowledge with specialization. A large section of doctors 95% of agreed that nutrition plays an important role in treatment and prescription and counseling of micronutrients is needed. But 82% of doctors are not sure and 8% even strongly disagreed if their patients will follow a diet plan even if given. Most of the study participants felt they were not up-to-date about micronutrients. Majority of them attributed this to lack of time and being unaware of any structured resource. Conclusion There is a need to restructure about imparting micronutrients education among doctors. Greater efforts should be aimed towards imparting updates about micronutrients in doctors and other health professionals enable them to contribute positively towards a healthy society. More Studies should be carried out in healthcare professionals. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.

Gurulingappa,MRMC | Aleem M.A.,MNR Medical College | Awati M.N.,MRMC | Adarsh S.,MRMC
Journal of Clinical and Diagnostic Research | Year: 2012

Background and objectives: Laryngoscopy and tracheal intubation is invariably associated with a reflex sympathetic pressor response resulting in elevated heart rate and blood pressures. This may prove detrimental in high risk patients. Objective of this study is to compare the effects of lignocaine and fentanyl in attenuation of this pressor response to laryngoscopy and tracheal intubation. Methods: Seventy five ASA I and II status normotensive patients scheduled for elective surgical procedures were selected randomly and divided into three groups of 25 each. All patients received premedication with pentazocine 0.05mg/kg i.v., atropine 0.01mg/ kg intramuscularly and midazolam 0.01mg/kg i.v. half an hour prior to induction. Induction of anesthesia was standardized for all patients who received, thiopentone 5 mg/kg i.v. and and were relaxed with succinylcholine 2mg/kg i.v. The first group received fentanyl 4micrograms/kg i.v bolus, the second group received lignocaine 1.5mg i.v bolus and then third group received placebo (normal saline), 5 minutes before laryngoscopy and intubation. HR, systolic, diastolic blood pressure were recorded noninvasively one day priorly B, Before induction 0 postinduction, 1,2,3,4 and 5 minutes from the onset of laryngoscopy. Results: After intubation incidence of tachycardia (HR>100/min) was significantly greater in placebo and lignocaine group than in fentanyl group (p<0.05). Rise in SBP and DBP were also statistically significant in placebo and lignocaine group than in fentanyl group (p<0.05). Conclusion: Attenuation of pressor response is seen both with lignocaine and fentanyl. Of the two drugs fentanyl 4mgicrogram i.v. bolus provides a consistent, reliable and effective attenuation as compared to lignocaine 1.5mg/kg iv. bolus.

Mukhopadhyay B.K.,MNR Medical College
World Journal of Laparoscopic Surgery | Year: 2013

Knots are very important in the general and laparoscopic surgery. Knots are of two types, extracorporeal and intracorporeal. Intracorporeal knots are difficult while extracorporeal knots are comparatively easy to make, as we make it outside. This new knot (Dilip-Sarbani knot) is an extracorporeal knot. We shall take 20 cm length suture material of prolene, vicryl or catgut. Then we shall take three simple rounds in left index finger. Then we shall mark it as no 1, 2 and 3. Then we shall take no 1 over no 2 and again no 2 over no 3 and lastly no 3 over no 1. Then we shall pull it tightly. The knot is prepared. Finally push the above portion of knot to the target organ for making it tight. If we want to be more secure then we can give one more simple knot. This knot can be used in tubal ligation, in appendectomy or where tubular structure and stump ligation.

Suguna D.,Mnr Medical College | Madhavi L.H.,Mnr Medical College | Nagaiah G.,Mnr Medical College
Indian Journal of Public Health Research and Development | Year: 2015

Context: An outbreak of gastro-enteritis occurred at Dubbaka village, Nizamabad District, Andhra Pradesh State, India. Aims: To investigate the gastro-enteritis out-break; identify the agent, source, mode of disease transmission and recommend control measures. Settings and Design: Cross-sectional study Method and Material: An outbreak investigation was carried out at Dubbaka village, Nizamabad District, Andhra Pradesh state, India during 16th to 23rd October 2010. Pre-tested, Pre-designed epidemiological case sheets were used. Ten stool and water samples were collected for laboratory analysis. Statistical analysis used: Chi-square test Results: Out of 3051 population, 471 cases were identified. Over-all attack rate was 15.43%, higher among above 14 yrs (20.32%) of age than in below 14yrs (8.1%), higher in females (16.17%) than in males (14.75%). The samples of stools and drinking water were positive for Escherichia coli. Conclusions: The present out-break was caused by contamination of drinking water. The quality of drinking water should be improved using locally available appropriate technology and resources. Solar water disinfection is a low cost method of purifying water that can often be implemented with locally available materials. © 2015, Indian Journal of Public Health Research & Development. All rights reserved.

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