andhra Pradesh, India
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Panta P.,MNR Dental College and Hospital
Analytical Cellular Pathology | Year: 2014

Oral squamous cell carcinomas (OSCC) are common malignancies that affect almost a million people every year.The key issue in reducing mortality and morbidity associated with OSCC is to develop novel strategies to identify OSCC at an early stage. One such strategy is the identification of biomarkers. So far, more than 100 biomarkers are recognized in the detection of oral cancer and they range from proteins to nucleic acids (DNAs, RNAs). Detection of ribose nucleic acids in saliva is a recent trend in diagnosing oral cancer. Studies have shown statistically significant changes in the levels of salivary transcriptomes in patients with oral squamous cell carcinomas. These biomarkers have displayed high sensitivity and specificity. Also, new point-of-care platforms such as oral fluid nanosensor test are now available that will soon emerge as chair-side tools for early detection of oral cancer.The aim of this review is to highlight the importance of salivary transcriptomes in oral cancer detection. Copyright © 2014 P. Panta and V. R. Venna.


PubMed | MNR Dental College and Hospital
Type: Journal Article | Journal: Journal of International Society of Preventive & Community Dentistry | Year: 2016

Attainment of ideal occlusion is often restricted by disproportionate sizes of individual teeth, which is otherwise termed as tooth size discrepancy (TSD). While extraction of teeth for orthodontic purposes is not uncommon, there is considerable resistance against this school of thought. The extraction of premolars, in particular, received considerable attention because of the potential TSD that could result following the extraction of premolars. The aim of the present study was to identify the consequence of premolar extractions on Boltons overall ratios in South Indian population.One hundred participants were recruited into the study through purposive nonproportionate quota sampling. Pretreatment dental casts of the study participants were measured for mesiodistal tooth widths to determine Boltons overall ratio before the hypothetical tooth extractions were performed. The hypothetical extractions were executed in four different combinations as follows: (a) Maxillary and mandibular first premolars, (b) maxillary first premolars and mandibular second premolars, (c) maxillary second premolars and mandibular first premolars, and (d) maxillary and mandibular second premolars. Boltons overall ratios were calculated after the hypothetical tooth extractions were performed. Statistical analysis was done using the Statistical Package for the Social Sciences, version 20 software.It was observed that extractions performed in any of the combinations followed in this study resulted in a decrease of overall Boltons ratios. However, the discrepancy in tooth size was highest with the extraction of all first premolars, whereas least discrepancy was recorded with all second premolars extraction. It was also found that, based on the combination of teeth chosen for extraction, there was significant difference in Boltons overall ratios between males and females.In formulating a treatment plan involving premolar extraction, significant tooth size discrepancies could change mutually after extraction.


PubMed | AMEs Dental College, Navodaya Dental College and Hospital and MNR Dental College and Hospital
Type: Journal Article | Journal: Journal of International Society of Preventive & Community Dentistry | Year: 2016

Dental and bone age is very essential for the dental practitioner in planning treatments and is an extra source of information for the pediatrician, orthopedician, and endocrinologist. There are few published data regarding collation between dental age, bone age, and chronological age in iron-deficiency anemic children. This study has been undertaken to evaluate and compare dental age, bone age, and chronological age in children with iron-deficiency anemia.One hundred iron-deficiency anemic children were selected in the age group of 8-14 years. Chronological age of the child was recorded by asking birth date from parents or checking school records. Dental age was calculated by Demirjians method and bone age was evaluated using Bjork, Grave, and Browns method. Unpaired students Dental and bone age was significantly lower (Dental and bone age retardation was a significant feature in our sample of 100 iron-deficient anemic children. Bone age and dental age are valuable parameters in assessing the overall growth of the child. Further studies are required to corroborate our findings.


PubMed | MNR Dental College and Hospital, Diagnostic Center and Life Prime Dental Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

For more than seven decades orthodontist used cephalometric analysis as one of the main diagnostic tools which can be performed manually or by software. The use of computers in treatment planning is expected to avoid errors and make it less time consuming with effective evaluation and high reproducibility.This study was done to evaluate and compare the accuracy and reliability of cephalometric measurements between computerized method of direct digital radiographs and conventional tracing.Digital and conventional hand tracing cephalometric analysis of 50 patients were done. Thirty anatomical landmarks were defined on each radiograph by a single investi-gator, 5 skeletal analysis (Steiner, Wits, Tweeds, McNamara, Rakosi Jarabaks) and 28 variables were calculated.The variables showed consistency between the two methods except for 1-NA, Y-axis and interincisal angle measurements which were higher in manual tracing and higher facial axis angle in digital tracing.Most of the commonly used measurements were accurate except some measurements between the digital tracing with FACAD


PubMed | Malla Reddy Institute of Medical science, Mamatha Dental College, Malla Reddy Institute of Dental science, SVS Institute of Dental science and 3 more.
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Langerhans Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen.The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium.A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.


PubMed | MNR Dental College and Hospital
Type: | Journal: The Pan African medical journal | Year: 2016

Mucormycosis is a rare, highly lethal opportunistic fungal disease affecting immune compromised and diabetic patients. Mucormycosis is considered as the 3(rd) most common invasive mycosis after candidiasis and aspergillosis in debilitating patients. It is caused by the filamentous fungi of the class zygomycetes. The infection usually begins in the nose due to inhalation of fungal spores. This fatal fungal disease needs a prompt and early definitive diagnosis, aggressive surgical therapy and high dose anti-fungal therapy. Here, we present a case report of Mucormycosis in a 64 year elderly diabetic male patient who was previously operated for myiasis and also the extensive review of the literature of the mucormycosis.


PubMed | MNR Dental College and Hospital
Type: | Journal: The Pan African medical journal | Year: 2016

Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, slow growing, characteristically shows infiltrative growth and perineural invasion. This paper reports a case of Adenoid Cystic Carcinoma in a 35 year old female man reported with a swelling on the left side of palate involving the hard and soft palate since 8 months which was diagnosed histopathologically and review of literature of the peculiar clinical, and histopathological features.


PubMed | MNR Dental College and Hospital and Reader
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Trigeminal Neuralgia (TN) is considered as one of the most painful neurologic disorders affecting oro-facial region. TN is often diagnosed clinically based on the patients complete history of pain (severity, duration, episodes etc), relief of pain on test dose of Carbamazepine, regional block of long acting anaesthetic. However, Magnetic Resonance Imaging (MRI) plays an important and confirmatory role in showing Neuro Vascular Conflict (NVC) which is the commonest causative factor for TN. This article reviews the effectiveness of three-dimensional constructive interference in steady-state (3D-CISS) MRI in diagnosing the exact location, degree of neurovascular conflict responsible for classical as well as atypical TN and possible pre-treatment evaluation and treatment outcome.


PubMed | MNR Dental College and Hospital and Panineeya Mahavidyalaya Institute of Dental science and Research Center
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Alendronate (ALN), an aminobisphosphonate, inhibits osteoclastic bone resorption and also stimulates osteogenesis. Beta-Tricalcium Phosphate (-TCP) is an osteoconductive graft material which provides a scaffold for bone formation and also a widely used drug delivery vehicle for growth factors and antibiotics. Drug delivery vehicles, like -TCP, improve the potency of the drugs by specific local site delivery of the drug, optimal release characteristics and easy handling.The aim of the this study was to evaluate the bone formation potential of 400g ALN delivered in -TCP in the treatment of periodontal intra-osseous defects.Thirty patients with periodontal defects were randomly assigned to 400g ALN + -TCP + Saline (test) group and -TCP + Saline (active-control) group. Clinical parameters like Clinical Attachment Level (CAL) gain, Probing Depth (PD) reduction, post-operative Gingival Recession (GR) were assessed from the baseline, 3 months and 6 months recordings. Radiographic parameters like Linear Bone Growth (LBG), Percentage Bone Fill (%BF), and change in alveolar crest height (ACH) were assessed from baseline and 6 months radiographs.Mean measurements in the ALN test group for CAL gain (3.4 0.74 mm), PD reduction (4.33 0.82 mm), LBG (2.88 0.88 mm), and %BF (51.98 15.84%) were significantly greater with a p-value <0.05 compared to the mean measurements of CAL gain (2.20 0.86 mm), PD reduction (3.20 1.15 mm), LBG (1.70 0.39 mm), and %BF (30.35 6.88%) of the control group. There was mild alveolar crestal apposition (0.32 0.68 mm) in the ALN test group and mild alveolar crestal resorption (-0.24 0.40 mm) in the control group.400g ALN combined with -TCP bone graft material was effective in improving soft tissue parameters, inhibiting alveolar crestal resorption and enhancing bone formation, compared to -TCP alone.


PubMed | MNR Dental College and Hospital and Malla Reddy Institute of Medical science MRIMS
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Oral Squamous Cell Carcinoma (OSCC) is a common malignancy involving head and neck. Identifying the markers of molecular levels or biochemical markers involving the various metabolic reactions associated with the initiation and biological behavior of individual tumors are very important in diagnosis and prognosis.To measure and compare the levels of serum Homocysteine (Hcy) and serum folate in OSCC patients, smoking group and healthy subjects and also to assess the clinical utility of serum Hcy as a potential tumor marker in OSCC.The study group comprised of 60 subjects, of whom 30 were classified as OSCC cases (GROUP I) and 15 were classified as smokers without OSCC (GROUP II). The control group included 15 healthy individuals without smoking habit (Group III). Hcy was measured with High Performance Liquid Chromatography (HPLC). Folate estimation was done by Chemiluminiscence Immuno Assay (CLIA). Comparison of mean Hcy and folate values among the groups was done using ANOVA with Post-Hoc Games Howell test. Gender was compared using Chi-square test. Comparison of mean age was using ANOVA with Post-Hoc Tukeys test.The mean serum folate level in OSCC patients was 5.34ng/mL, 7.68ng/mL in smoking group and 10.99ng/mL in control group. There was a significant difference in the mean serum folate levels among the three study groups (p<0.001). The mean serum Hcy in OSCC patients was 23.58mol/L, 17.46mol/L, in smoking group and 10.76mol/l in controls. There was a significant difference in the mean serum Hcy levels among the three study groups (p<0.001).The present study found an interesting association with serum Hcy and folate levels in OSCC which could be useful as a biochemical Tumor Marker and thereby providing insights into the onset and progression of the disease.

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