MNR Dental College and Hospital

andhra Pradesh, India

MNR Dental College and Hospital

andhra Pradesh, India
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Oggu G.S.,CSIR - Central Electrochemical Research Institute | Sasikumar S.,CSIR - Central Electrochemical Research Institute | Reddy N.,MNR Dental College and Hospital | Ella K.K.R.,MNR Dental College and Hospital | And 2 more authors.
Stem Cell Reviews and Reports | Year: 2017

A significant number of clinical trials have been undertaken to explore the use of mesenchymal stem cells (MSCs) for the treatment of several diseases such as Crohn’s disease, diabetes, bone defects, myocardial infarction, stroke etc., Due to their efficiency in homing to the tissue injury sites, their differentiation potential, the capability to secrete a large amount of trophic factors and their immunomodulatory effects, MSCs are becoming increasingly popular and expected to be one of the promising therapeutic approaches. However, challenges associated with the isolation of pure MSC populations, their culture and expansion, specific phenotypic characterization, multi-potential differentiation and challenges of efficient transplantation limit their usage. The current strategies of cell-based therapies emphasize introducing beneficial genes, which will improve the therapeutic ability of MSCs and have better homing efficiency. The continuous improvement in gene transfer technologies has broad implications in stem cell biology. Although viral vectors are efficient vehicles for gene delivery, construction of viral vectors with desired genes, their safety and immunogenicity limit their use in clinical applications. We review current gene delivery approaches, including viral and plasmid vectors, for transfecting MSC with beneficial genes. The review also discusses the use of a few emerging technologies that could be used to improve the transfer/induction of desirable genes for cell therapy. © 2017 Springer Science+Business Media, LLC


Colvenkar S.S.,MNR Dental College and Hospital
Indian Journal of Dental Research | Year: 2010

Aim: The need for denture marking is important for forensic and social reasons in case patients need to be identified individually. Majority of the surface marking and inclusion techniques are expensive, time consuming, and do not permit the incorporation of large amounts of information. In this article, the method to include a lenticular identification card stood out from the currently available denture marking methods in various ways. The lenticular card stores the patient's information has two or more images that can be viewed by changing the angle of view. Materials and Methods: The maxillary denture was processed according to the manufacturer's instructions. The lenticular identification card was incorporated in the external posterior buccal surface of the maxillary denture using salt and pepper technique. For testing of durability, denture with the identifier was placed in water for up to 4 months. Conclusion: The proposed method is simple, cheap, and can store a large amount of information, thus allowing quick identification of the denture wearer. The labels showed no sign of fading or deterioration.


Panta P.,MNR Dental College and Hospital
Indian Journal of Palliative Care | Year: 2017

Background of Hypothesis: Myofascial pain syndrome (MPS) is the most common musculoskeletal pain disorder of the head and neck area. In the past, several theories were put forth to explain its origin and nature, but none proved complete. Myofascial pain responds to changing psychological states and stress, anxiety, lack of sleep, anger, depression and chronic pain are direct contributional factors. Myofascial pain syndrome may be considered as a psychosomatic disorder. There are numerous accepted palliative approaches, but of all, relaxation techniques stand out and initiate healing at the base level. In this article, the connection between mental factors, MPS and meditation are highlighted. Recent literature has shed light on the fundamental role of free radicals in the emergence of myofascial pain. The accumulating free radicals disrupt mitochondrial integrity and function, leading to sustenance and progression of MPS. Meditation on the other hand was shown to reduce free radical load and can result in clinical improvement. 'Mindfulness' is the working principle behind the effect of all meditations, and I emphasize that it can serve as a potential tool to reverse the neuro-architectural, neurobiological and cellular changes that occur in MPS. Conclusions: The findings described in this paper were drawn from studies on myofascial pain, fibromyalgia, similar chronic pain models and most importantly from self experience (experimentation). Till date, no hypothesis is available connecting MPS and meditation. Mechanisms linking MPS and meditation were identified, and this paper can ignite novel research in this direction. © 2017 Indian Journal of Palliative Care | Published by Wolters Kluwer -Medknow.


Panta P.,MNR Dental College and Hospital
Analytical Cellular Pathology | Year: 2014

Oral squamous cell carcinomas (OSCC) are common malignancies that affect almost a million people every year.The key issue in reducing mortality and morbidity associated with OSCC is to develop novel strategies to identify OSCC at an early stage. One such strategy is the identification of biomarkers. So far, more than 100 biomarkers are recognized in the detection of oral cancer and they range from proteins to nucleic acids (DNAs, RNAs). Detection of ribose nucleic acids in saliva is a recent trend in diagnosing oral cancer. Studies have shown statistically significant changes in the levels of salivary transcriptomes in patients with oral squamous cell carcinomas. These biomarkers have displayed high sensitivity and specificity. Also, new point-of-care platforms such as oral fluid nanosensor test are now available that will soon emerge as chair-side tools for early detection of oral cancer.The aim of this review is to highlight the importance of salivary transcriptomes in oral cancer detection. Copyright © 2014 P. Panta and V. R. Venna.


PubMed | AMEs Dental College, Navodaya Dental College and Hospital and MNR Dental College and Hospital
Type: Journal Article | Journal: Journal of International Society of Preventive & Community Dentistry | Year: 2016

Dental and bone age is very essential for the dental practitioner in planning treatments and is an extra source of information for the pediatrician, orthopedician, and endocrinologist. There are few published data regarding collation between dental age, bone age, and chronological age in iron-deficiency anemic children. This study has been undertaken to evaluate and compare dental age, bone age, and chronological age in children with iron-deficiency anemia.One hundred iron-deficiency anemic children were selected in the age group of 8-14 years. Chronological age of the child was recorded by asking birth date from parents or checking school records. Dental age was calculated by Demirjians method and bone age was evaluated using Bjork, Grave, and Browns method. Unpaired students Dental and bone age was significantly lower (Dental and bone age retardation was a significant feature in our sample of 100 iron-deficient anemic children. Bone age and dental age are valuable parameters in assessing the overall growth of the child. Further studies are required to corroborate our findings.


PubMed | MNR Dental College and Hospital, Diagnostic Center and Life Prime Dental Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

For more than seven decades orthodontist used cephalometric analysis as one of the main diagnostic tools which can be performed manually or by software. The use of computers in treatment planning is expected to avoid errors and make it less time consuming with effective evaluation and high reproducibility.This study was done to evaluate and compare the accuracy and reliability of cephalometric measurements between computerized method of direct digital radiographs and conventional tracing.Digital and conventional hand tracing cephalometric analysis of 50 patients were done. Thirty anatomical landmarks were defined on each radiograph by a single investi-gator, 5 skeletal analysis (Steiner, Wits, Tweeds, McNamara, Rakosi Jarabaks) and 28 variables were calculated.The variables showed consistency between the two methods except for 1-NA, Y-axis and interincisal angle measurements which were higher in manual tracing and higher facial axis angle in digital tracing.Most of the commonly used measurements were accurate except some measurements between the digital tracing with FACAD


PubMed | Malla Reddy Institute of Medical science, Mamatha Dental College, Malla Reddy Institute of Dental science, SVS Institute of Dental science and 3 more.
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Langerhans Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen.The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium.A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.


PubMed | MNR Dental College and Hospital
Type: | Journal: The Pan African medical journal | Year: 2016

Mucormycosis is a rare, highly lethal opportunistic fungal disease affecting immune compromised and diabetic patients. Mucormycosis is considered as the 3(rd) most common invasive mycosis after candidiasis and aspergillosis in debilitating patients. It is caused by the filamentous fungi of the class zygomycetes. The infection usually begins in the nose due to inhalation of fungal spores. This fatal fungal disease needs a prompt and early definitive diagnosis, aggressive surgical therapy and high dose anti-fungal therapy. Here, we present a case report of Mucormycosis in a 64 year elderly diabetic male patient who was previously operated for myiasis and also the extensive review of the literature of the mucormycosis.


PubMed | MNR Dental College and Hospital and Reader
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Trigeminal Neuralgia (TN) is considered as one of the most painful neurologic disorders affecting oro-facial region. TN is often diagnosed clinically based on the patients complete history of pain (severity, duration, episodes etc), relief of pain on test dose of Carbamazepine, regional block of long acting anaesthetic. However, Magnetic Resonance Imaging (MRI) plays an important and confirmatory role in showing Neuro Vascular Conflict (NVC) which is the commonest causative factor for TN. This article reviews the effectiveness of three-dimensional constructive interference in steady-state (3D-CISS) MRI in diagnosing the exact location, degree of neurovascular conflict responsible for classical as well as atypical TN and possible pre-treatment evaluation and treatment outcome.


PubMed | MNR Dental College and Hospital and Panineeya Mahavidyalaya Institute of Dental science and Research Center
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Alendronate (ALN), an aminobisphosphonate, inhibits osteoclastic bone resorption and also stimulates osteogenesis. Beta-Tricalcium Phosphate (-TCP) is an osteoconductive graft material which provides a scaffold for bone formation and also a widely used drug delivery vehicle for growth factors and antibiotics. Drug delivery vehicles, like -TCP, improve the potency of the drugs by specific local site delivery of the drug, optimal release characteristics and easy handling.The aim of the this study was to evaluate the bone formation potential of 400g ALN delivered in -TCP in the treatment of periodontal intra-osseous defects.Thirty patients with periodontal defects were randomly assigned to 400g ALN + -TCP + Saline (test) group and -TCP + Saline (active-control) group. Clinical parameters like Clinical Attachment Level (CAL) gain, Probing Depth (PD) reduction, post-operative Gingival Recession (GR) were assessed from the baseline, 3 months and 6 months recordings. Radiographic parameters like Linear Bone Growth (LBG), Percentage Bone Fill (%BF), and change in alveolar crest height (ACH) were assessed from baseline and 6 months radiographs.Mean measurements in the ALN test group for CAL gain (3.4 0.74 mm), PD reduction (4.33 0.82 mm), LBG (2.88 0.88 mm), and %BF (51.98 15.84%) were significantly greater with a p-value <0.05 compared to the mean measurements of CAL gain (2.20 0.86 mm), PD reduction (3.20 1.15 mm), LBG (1.70 0.39 mm), and %BF (30.35 6.88%) of the control group. There was mild alveolar crestal apposition (0.32 0.68 mm) in the ALN test group and mild alveolar crestal resorption (-0.24 0.40 mm) in the control group.400g ALN combined with -TCP bone graft material was effective in improving soft tissue parameters, inhibiting alveolar crestal resorption and enhancing bone formation, compared to -TCP alone.

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