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Ghāziābād, India

Nangia S.,Medical Research Center | Chufal K.S.,Medical Research Center | Tyagi A.,Medical Research Center | Tyagi A.,Mmh College | And 3 more authors.
International Journal of Radiation Oncology Biology Physics | Year: 2010

Purpose: We have been using intensity-modulated radiotherapy (IMRT) for selective neck irradiation. This article presents an analysis of patterns of failure and their dosimetric correlation. Methods and Materials: Between October 2003 and January 2008, 83 patients with head-and-neck cancer were treated with IMRT. Nodal levels were contoured as per the Radiation Therapy Oncology Group (RTOG) consensus guidelines. Results: There were 32 relapses with 23 local relapses (21 local relapses alone and 2 local and regional relapses, simultaneously), 9 regional relapses (including 2 simultaneous local and regional relapses), and 5 distant relapses, of which 2 patients had local relapses. At 2 and 3 years, the locoregional relapse-free survival rates were was 68.3% and 60.8%, respectively, while the overall survival rates were 84.1% and 81.7%, respectively. Subgroup analyses revealed significant differences in locoregional relapse-free survival rates for total treatment times of <53 days vs. >53 days, a volume of CTV1PTV (i.e., the volume prescribed 70 Gy) <177 cc vs. >177 cc, a V100 for CTV1PTV of <91% vs. >91%, and a minimum dose to CTV1PTV of <54 Gy vs. >54 Gy. There were no failures in the elective nodal volume, substantiating both the nodal selection criteria and the RTOG consensus guidelines for delineation of neck node levels. Conclusions: IMRT for head-neck cancer is feasible, using elective nodal selection criteria along with RTOG consensus guidelines for the radiological boundaries of levels of neck nodes. © 2010 Elsevier Inc. All rights reserved.

Chaudhary P.,Mmh College
Indian Journal of Physics | Year: 2011

The classical electrodynamics for dyons in six-dimensional space-time has been studied in terms of generalized potentials and fields. Choosing a suitable Lagrangian in six-space, it has been shown that the magnetically charged particles necessarily require temporal degrees of freedom and to develop a consistent covariant theory for all relativistic phenomena the study of dyon in six-space appears as a natural choice. Extending generalized potentials and fields to account for additional temporal degrees of freedom the field equations have been derived in six-space. The dynamics of massive spin-1 dyon has been discussed under space-time dependent structural mappings and it has been shown that the force experienced by dyon considerably depends on the selection of trajectory of space-time. © 2011 IACS.

Pandey M.K.,Indian Pharmacopoeia Commission | Singh G.N.,Indian Pharmacopoeia Commission | Sharma R.K.,Pharmacopoeia Laboratory of Indian Medicine | Lata S.,Mmh College
Journal of Applied Pharmaceutical Science | Year: 2011

Eclipta alba (L.) Hassk is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical regions. The herb has been known for its curative properties and has been utilized as antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. The present study confirmed the antibacterial potential of aerial parts extracts of Eclipta alba in solvents like acetone, ethanol, methanol, aqueous and hexane against selected gram positive and gram negative bacterial species. The antibacterial studies were done by agar well diffusion methods. The MIC and MBC methods were also used. Hexane extract of showed Eclipta alba high antibacterial activity against S.aureus, B.cereus, E.coli, S.typhi, K.pneumoniae,S.pyogenes and P.aeruginosa. whereas acetone, ethanol, methanol and aqueous extracts showed intermediate activity against S.aureus, B.cereus, E.coli, S.typhi, K.pneumoniae, P.aeruginosa, P.mirabilis and S.pyogenes. The inhibitory activities of all the extracts reported were compared with standard antibiotics (Ciprofloxacin 25 μg/ml). An MIC of 90.0μg/ml shown by E.coli and S.aureus was considered to be the best (below 100μg/ml), an MIC of 125.0μg/ml shown by E.coli, K.pneumoni, P.mirabilis and S.typhi was considered to be better (100-500μg/ml) as such by the action of acetone, ethanol, methanol and hexane extracts on test bacterial spp respectively MIC between (500-1000μg/ml) was considered to be good. The aqueous extracts of Eclipta alba showed good activity against S.pyogenes, B.cereus, E.coli and P.aeruginosa. If the dilution was above 1000μg/ml the extract were considered inactive against S.aureus, K.pneumoniae, P.mirabilis and S.typhi. MBC results were similar to MIC results but in the case of MBC the confirmation was made by absence of growth in culture plates after 24 hrs of incubation at 37°C. A potent antibacterial and hepatoprotective drug could probably be formulated from the plant extract of Eclipta alba to combat the effects of bacterial and hepatotoxic infections.

Verma S.C.,Institutional Area | Jain C.L.,Mmh College | Padhi M.M.,Institutional Area
Asian Journal of Chemistry | Year: 2011

Economical and simple microwave-assisted extraction of Cynodon dactylon whole plant and simultaneously quantitative analysis of four phenolics viz., 4-hydroxy benzoic acid (1), vanillic acid (2), 4-hydroxy benzaldehyde (3) and ferulic acid (4) have been carried out by diode array detection with RP-HPLC. Ethanol as a solvent and microwave's irradiation time 120 s were found to be most favourable for maximum extraction of desired compounds 1-4. The samples were separated on Eclipse XDB-C18 column with gradient elution of acetonitrile and water: trifluoroacetic acid (99.5:0.05, v/v, pH 2.9) at a flow rate 1.0 mL/min and detected at 280 nm. All calibration curves showed good linearity (r2 > 0.999). The LOD and LOQ were found in the range 0.12-0.27 and 0.40-0.89 μg/mL, respectively. Good recoveries were achieved (92.56-104.89 %) within range. Compound 1 was found in maximum quantity (= 10.312 |μg/mL) while compound 4 was found in least quantity (3.621 μg/mL). This method will be useful for quality control and assessment of C. dactylon containing product.

Gupta N.J.,Mmh College | Gupta N.J.,University of Delhi
Indian Journal of Experimental Biology | Year: 2014

To test the circadian clock characteristics, activity behaviour of male blackheaded munia was recorded. Two experiments were performed. In experiment 1A, activity of munia was recorded under long days, LD (14L: 10D); and short days, SD (10L: 14D). Locomotor activity of two groups of munia exposed to equinox (12L: 12D) daylength followed by transfer of one group each to continuous dimlight (DD) and continuous bright light (LL) was recorded in experiment 1B. Experiment 2 aimed to describe seasonal trend in daily pattern of activity/rest cycle under natural illumination conditions (NDL). Hourly activity during daytime was more under SD than under L.D. Munia did not exhibit bimodality in daily activity pattern; activity during morning, M (2h) was more than evening, E. A free-running activity rhythm was recorded in munia under DD; the same was arrhythmic under L.L. The seasonal pattern in daily activity profiles under NDL corresponds to the seasonal changes in daylength. Daylength regulates daily and seasonal activity patterns in blackheaded munia.

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