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Mysore, India

Hegde S.S.,MMC and RI | Mallesh P.,S.S.I.M.S. | Yeli S.M.,J.J.M.M.C | Gadad V.M.,NIMHANS | Giri Punja M.,MMC and RI
Journal of Clinical and Diagnostic Research

Aims and Objectives: To study angiographic extents, type of vessels, number of vessels, severity involving coronary artery and its branches in patients with acute coronary syndrome(ACS).Compare the same in diabetics and non diabetics with ACS.Background: Cardiac adversity is by far the commonest cause of mortality in patients with diabetes. Cardiac involvement in diabetes commonly manifest as coronary artery disease (CAD). Definitive diagnosis,precise assessment and anatomic severity of CAD requires invasive diagnostic modality like coronary angiography.Materials and Methods: Hundred patients with ACS,50 diabetics and 50 nondiabetics admitted in Bapuji Hospital ICCU attached to J.J.M. Medical College were selected randomly during a period of approximately one and half years formed the study group. RBS, FBS was done in all 100 pateints, HbA1c in all diabetics. All subjects with ACS were taken up for coronary angiography.Statistical Analysis: Chi-square test was used to determine any significant difference between two groups. p-value of less than 0.05 was considered significant.Results: In our study 22 (44%) out of 50 diabetic patients had triple or multi-vessel disease compared to 8 (16%) out of 50 non diabetics. 100 patients with ACS, number of vessels involved were 199, of which 61.3%in diabetics and 38.6% in non diabetics.23(46%) of 50 diabetic patients required CABG as treatment outcome. HbA1c levels of >8.5%, 69.2% had triple/multi vessel disease and 19 (73.1%) of 23 patients who had to undergo CABG had HbA1c levels >8.5%. 24% of diabetics were in third decade, 40% were in fourth decade as compared to 10% and 26% of non-diabetics of similar age group.Interpretation and Conclusion: This study showed that ACS in diabetic patients presented much earlier in life, the severity and extent of coronary artery disease and incidence of triple/multi vessel disease was significantly high in diabetics when compared to nondiabetics with ACS. Diabetics with high HbA1c had more number of coronary vessel involvement and the mode of treatment required in them was CABG. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Karthik K.S.,MMC and RI | Chandra B.,MMC and RI | Balakrishna M.A.,MMC and RI | Deepthi B.R.,MMC and RI
Journal of Clinical and Diagnostic Research

Background: Thyroid enlargement has been a common problem encountered in general surgical practice. Thyroid being an endocrine gland, its involvement has a diverse issue from a meagre cosmetic problem to a more concerned malignancy. Aim: This study was conducted to study the age and sex distribution along with the mode of presentation of Multinodular Goitre (MNG). The incidence of malignancy and the surgical complications in the study population were also studied. Materials and Method: In this descriptive study, patients diagnosed with MNG from January 2011 to July 2012 were chosen from the in-patient of our teaching hospital. One hundred such patients who qualified to undergo surgery were included in the study after a detailed history and clinical examination. Patients underwent Fine needle aspiration cytology (FNAC) for preoperative pathological diagnosis and the goitre was confirmed to be benign. Patients diagnosed with malignancy were excluded from the study. Following thyroidectomy, the thyroid specimens were subjected to histopathological examination. Results: Among the 100 cases of MNG, 59% patients belonged to 3rd and 4th decade of life, 90% patients were females, 82% presented before 5yrs. The most common symptom at presentation was swelling (100%). Among the patients 80% were in euthyroid state, 19% were hyperthyroid and 1% hypothyroid. Most of the patients were treated with sub-total thyroidectomy (59%), followed by total (20%), near total (11%), and Hemithyroidectomy (10%). Following surgery complications like stridor and laryngeal oedema (3%), wound infection (2%), hypocalcemia (2%), haemorrhage (1%) and seroma (1%) were noted. On Histopathological examination (HPE) of the surgical specimen, 3% were reported to be malignant. Conclusion: As noted by this study, Multinodular Goitre is more common among females in the third and fourth decades. Patients can present with various complaints. MNG can present as hyperthyroid, hypothyroid but mostly in euthyroid state. The indication for surgery in patients with MNG includes cosmesis, hyperthyroidism, local compressive symptoms and most importantly malignancy. Subtotal thyroidectomy is the preferred surgery, but a trend towards total and near total thyroidectomy is noticeably replacing the old belief in subtotal thyroidectomy. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved. Source

Amrutha Kumari B.,MMC and RI | Deepa S.,MMC and RI | Venkatesha D.,MMC and RI
Online Journal of Health and Allied Sciences

Introduction: There is a risk of 1-2 per 1000 recipients receiving contaminated blood with viral, bacterial and parasitic agents.TTI'S are the most commonly encountered complications in transfusion medicine. The objective of the study was to determine the seroprevalence of TTI's among blood donors, who represent healthy population at large. Materials & methods: A total of 33,658 blood units were received from voluntary and replacement donors over a period of 5 years. Surface antigen of HBV and antibodies to HIV and HCV were determined using ELISA. Syphilis was detected using TPHA test. Results: 947 (2.81%) blood units tested positive for HBV, HCV, HIV and/or syphilis. Overall prevalence was HBV-1.77%, HCV-0.13%, HIV-0.63% and Syphilis-0.28%. Nine (0.03%) donors had coinfections. Conclusion: The screening of blood donors is the corner stone in assuring the safety of blood transfusion. Source

Bhanutej T.R.,MMC and RI | Rayamane A.P.,MMC and RI | Saraf A.,MMC and RI | Dayanada R.,MMC and RI | And 2 more authors.
Journal of South India Medicolegal Association

Suicide by soft methods such as poisoning is one of the commonly used methods in India. Medical professionals, medical students, paramedical staff who can easily accessible of medicinal drugs may use these drugs for suicidal purpose. Here with reporting a case of suicide by intravenous fluticasone propionate this was meant for intranasal spray for treatment of perennial rhinitis. © 2015 South India Medico-Legal Association. All rights reserved. Source

Deepak T.S.,MMC and RI | Raveesh B.N.,MMC and RI | Parashivamurthy B.M.,MMC and RI | Narendra Kumar M.S.,MMC and RI | And 2 more authors.
Journal of Clinical and Diagnostic Research

Background: Atypical antipsychotics appear to have the greatest potential to induce weight gain. Antipsychotic-induced weight gain is the one of main cause of non-compliance and discontinuation of treatment, often resulting in the relapse of psychosis. Objective: To compare the weight gain between amisulpride and blonanserin treatment, in persons with psychosis. Materials and Methods: Fifty six subjects with psychosis attending psychiatry department at KR Hospital, Mysore were randomized into two equal groups. After obtaining informed consent, subjects of group I received amisulpride tablets 200 mg BD, and group II received blonanserin tablets 4 mg BD, for eight weeks. Body weight, Body Mass Index (BMI) and Waist Hip Ratio (WHR) were measured at baseline, 4 weeks and 8 weeks. Results: The mean weight gain with amisulpride at 4 weeks was 2.73 kg (5.21%) and at 8 weeks was 4.34 kg (8.28%) from the baseline. The mean weight gain with blonanserin at 4 weeks was 1.77 kg (3.46%) and at 8 weeks was 3.46 kg (6.75%) from the baseline. The mean BMI increase at 8 weeks with amisulpride was 1.66 ± 0.56 and with blonanserin was 1.34 ± 0.77. The mean WHR increase at 8 weeks with amisulpride was 0.036 ± 0.026 and with blonanserin was 0.029 ± 0.020. There was statistically significant increase in weight, BMI and WHR associated with both blonanserin and amisulpride at 8 weeks. But there was no statistically significant difference in those parameters between blonanserin and amisulpride, at eight weeks. Conclusion: Even though there was no significant difference in the weight gain caused by blonanserin, in comparison with amisulpride, both these drugs individually caused significant weight gain at 8 weeks, which is in contrast with the earlier studies, which needs to be further evaluated. © 2015, Journal of Clinical and Diagnostic Research. All right reserved. Source

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