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Kanai T.,Keio University | Mikami Y.,Keio University | Hayashi A.,Keio University | Hayashi A.,Miyarisan Pharmaceutical Co.
Journal of Gastroenterology | Year: 2015

Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows the identification of microbiota alterations in IBD. Several studies have shown reduced diversity in the gut microbiota of patients with IBD. Advances in gnotobiotic technology have made possible analysis of the role of specific bacterial strains in immune cells in the intestine. Using these techniques, we have shown that Clostridium butyricum as a probiotic induces interleukin-10-producing macrophages in inflamed mucosa via the Toll-like receptor 2/myeloid differentiation primary response gene 88 pathway to prevent acute experimental colitis. In this review, we focus on the new approaches for the role of specific bacterial strains in immunological responses, as well as the potential of bacterial therapy for IBD treatments. © 2015, Springer Japan.


Ohtani K.,Miyarisan Pharmaceutical Co. | Ohtani K.,Kanazawa University
Anaerobe | Year: 2016

The Gram-positive anaerobic spore-forming rod, Clostridium perfringens, is widely distributed in nature, especially in soil and the gastrointestinal tract of humans and animals. C. perfringens produces many secreted toxins and enzymes that are involved in the pathogenesis of gas gangrane and gastrointestinal disease. One of the most important systems regulating the production of these proteins in C. perfringens is the VirS/VirR-VR-RNA signal transduction cascade. The Agr system also important for the regulation of toxin genes. VirS appears to sense the peptide produced by the Agr (accessory gene regulator) system. The VirS/VirR-VR-RNA cascade controls the pathogenesis of C. perfringens infections by regulating virulence related genes and genes for energy metabolism. These systems are important for the host cell-induced upregulation of toxin production. © 2016 Elsevier Ltd


The present invention provides an adjunctive agent and a method for lavaging the alimentary canal, which is able to reduce a dose of oral cleaning agent for lavaging the alimentary canal and is capable of realizing an excellent cleaning effect at the time of use of the oral cleaning agent. The adjunctive agent comprises butyric acid bacterium (for example, Clostridium butyricum and the like) and/or lactic acid bacterium (for example, species belonging to the genus Lactobacillus and the genus Bifidobacterium).


To provide a means for preventing, treating and/or controlling health damages, including food poisoning and infections, caused by a bacterium belonging to the genus Clostridium. The above object can be solved by a cyclic peptide containing the sequence Cys-Phe-Trp-Ala-His and/or a broth of Clostridium butyricum.


To provide a means for preventing, treating and/or controlling health damages, including food poisoning and infections, caused by a bacterium belonging to the genus Clostridium. The above object can be solved by a cyclic peptide containing the sequence Cys-Phe-Trp-Ala-His and/or a broth of Clostridium butyricum.


Trademark
Miyarisan Pharmaceutical Co. | Date: 2013-12-02

Microbiological preparations and cultures of microorganisms as food ingredients other than for medical and veterinary use. Pharmaceutical preparations, namely, antiflatulants not for use in treating teeth, the oral cavity, the pharynx, and the lips; nutritional supplements not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements adapted for medical purposes not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietetic beverages adapted for medical purposes, not for use in treating teeth, the oral cavity, the pharynx, and the lips; food for babies not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements for animals not for use in treating teeth, the oral cavity, the pharynx, and the lips; pharmaceutical preparations and biological tissue cultures of microorganisms as food ingredients for medical and veterinary use not for use in treating teeth, the oral cavity, the pharynx, and the lips; non-medicated additives for animal feed for use as nutritional supplements. Animal foodstuffs; animal fattening preparations not for medical purposes, namely, fodder.


Trademark
Miyarisan Pharmaceutical Co. | Date: 2013-12-02

Microbiological preparations and cultures of microorganisms as food ingredients other than for medical and veterinary use. Pharmaceutical preparations, namely, antiflatulants not for use in treating teeth, the oral cavity, the pharynx, and the lips; nutritional supplements not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements adapted for medical purposes not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietetic beverages adapted for medical purposes, not for use in treating teeth, the oral cavity, the pharynx, and the lips; food for babies not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements for animals not for use in treating teeth, the oral cavity, the pharynx, and the lips; pharmaceutical preparations and biological tissue cultures of microorganisms as food ingredients for medical and veterinary use not for use in treating teeth, the oral cavity, the pharynx, and the lips; non-medicated additives for animal feed for use as nutritional supplements. Animal foodstuffs; animal fattening preparations not for medical purposes, namely, fodder.


Trademark
Miyarisan Pharmaceutical Co. | Date: 2013-12-02

Microbiological preparations and cultures of microorganisms as food ingredients other than for medical and veterinary use. Pharmaceutical preparations, namely, antiflatulants not for use in treating teeth, the oral cavity, the pharynx, and the lips; nutritional supplements not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements adapted for medical purposes not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietetic beverages adapted for medical purposes, not for use in treating teeth, the oral cavity, the pharynx, and the lips; food for babies not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements for animals not for use in treating teeth, the oral cavity, the pharynx, and the lips; pharmaceutical preparations and biological tissue cultures of microorganisms as food ingredients for medical and veterinary use not for use in treating teeth, the oral cavity, the pharynx, and the lips; non-medicated additives for animal feed for use as nutritional supplements. Animal foodstuffs; animal fattening preparations not for medical purposes, namely, fodder.


Trademark
Miyarisan Pharmaceutical Co. | Date: 2013-12-02

Microbiological preparations and cultures of microorganisms as food ingredients other than for medical and veterinary use. Pharmaceutical preparations, namely, antiflatulants not for use in treating teeth, the oral cavity, the pharynx, and the lips; nutritional supplements not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements adapted for medical purposes not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietetic beverages adapted for medical purposes, not for use in treating teeth, the oral cavity, the pharynx, and the lips; food for babies not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements for animals not for use in treating teeth, the oral cavity, the pharynx, and the lips; pharmaceutical preparations and biological tissue cultures of microorganisms as food ingredients for medical and veterinary use not for use in treating teeth, the oral cavity, the pharynx, and the lips; non-medicated additives for animal feed for use as nutritional supplements. Animal foodstuffs; animal fattening preparations not for medical purposes, namely, fodder.


Trademark
Miyarisan Pharmaceutical Co. | Date: 2015-07-15

Dietary supplements for animals not for use in treating teeth, the oral cavity, the pharynx, and the lips; non-medicated additives for animal feed for use as nutritional supplements; nutritional supplements not for use in treating teeth, the oral cavity, the pharynx, and the lips; dietary supplements adapted for medical purposes not for use in treating teeth, the oral cavity, the pharynx, and the lips; Pharmaceutical preparations, namely, antiflatulants not for use in treating teeth, the oral cavity, the pharynx, and the lips; pharmaceutical preparation for treatment and prevention of gastrointestinal diseases, namely, irritable bowel syndrome, inflammatory bowel diseases, antibiotic associated diarrhea, infectious diarrhea, constipation, acute and chronic diarrhea, and soft stool; cultures of microorganisms for medical and veterinary use; bacteriological preparations for medical and veterinary use; bacteriological culture mediums; food for babies not for use in treating teeth, the oral cavity, the pharynx, and the lips. Animal foodstuffs; animal fattening preparations not for medical purposes, namely, fodder.

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