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Miyama, Japan

Harada K.,Miyama Co. | Yanagisawa Y.,Miyama Co. | Saito J.,Medical Station Clinic | Iizuka M.,TTC Co.
Japanese Pharmacology and Therapeutics | Year: 2013

Objective: The aim of this study was to evaluate the effectiveness of lactic bacteria-containing kimchi on the blood cholesterol level, defecation status, and skin conditions. Methods: Thirteen subjects (6 males and 7 females) who had relatively higher serum total cholesterol level (229±17mg/dL) were enrolled in an open-labeled study, in which self-assessed skin conditions and defecation status as well as blood biochemistry were evaluated following intake of lactic bacteria-containing kimchi for 8 weeks at a daily dose of 50 g. Results: The consumption of test food for 8 weeks resulted in a slight reduction of total cholesterol levels with respect to all the subjects (by 2.8±13.4 mg/dL), while, in 5 subjects who had both total cholesterol and LDL-cholesterol levels higher than the guideline levels, the reduction was 11.4±9.9 mg/dL (P=0.062 by Student's paired f-test). The skin conditions were significantly improved with respect to total satisfaction (at the 4th week), moist feeling (at the 4th week), and texture (at the 4th and 8th weeks) (P<0.05 for all the parameters by Wilcoxon signed-rank test). Significant improvements were also observed with defecation status with respect stool frequency and strain at stool (P<0.05 for both parameters by Wilcoxon signed-rank test). Conclusions: The consumption of lactic bacteria-containing kimchi is suggested to improve subjective quality of defecation and skin condition. Source


Yanagisawa Y.,Miyama Co. | Yamamoto T.,TTC Co.
Japanese Pharmacology and Therapeutics | Year: 2014

Objective: The aim of this study was to evaluate the intake of lactic bacteria (Lactobacillus brevis) on skin conditions in women who had mild dry skin conditions.Methods: Ten female subjects (average of 35.1 ± 8.6 years old) who had mild dry skin conditions received lactic bacteria (4 g; ∼4×10l0 cells) daily for 8 weeks, and skin conditions including skin hydration state, transepidermal water loss (TEWL), and skin viscoelasticity were evaluated.Results: The intake of lactic bacteria for 8 weeks significantly improved TEWL in the left forearm (from 7.35 ±1.61 to 6.83 ± 1.27 g/m2 h; P<0.05 by paired Student's f-test). Regarding the skin viscoelasticity, the parameters R5 (net elasticity) and R7 (the ratio of elastic recovery to the total deformation) significantly increased after 8 weeks of the intake of lactic bacteria (from 0.403±0.055 to 0.433±0.034Ur/Ue and from 0.268±0.045 to 0.289± 0.032Ur/Uf, respectively; P<0.05 by paired Student's r-test). A questionnaire revealed that subjective skin conditions significantly improved after the intake of lactic bacteria for 8 weeks.Conclusions: The intake of lactic bacteria is suggested to improve both objective and subjective quality of skin conditions. Source


Yanagisawa Y.,Miyama Co. | Yamamoto T.,TTC Co. | Saito J.,Medical Station Clinic
Japanese Pharmacology and Therapeutics | Year: 2014

Objective: The aim of this study was to evaluate the intake of lactic bacteria (Lactobacillus brevis Miyavis LB) on immune function in healthy adult volunteers with slightly reduced salivary secretory immunoglobulin A (slgA). Methods: Eleven subjects (average of 41.0± 10.1 years old) who had slightly reduced salivary slgA received lactic bacteria (4 g; ∼4 X 1010 cells) daily for 8 weeks, and their immune functions, including salivary slgA level, natural killer (NK) cell activity, and lymphocyte blastoid transformation, were evaluated. Results: The intake of lactic bacteria for 8 weeks significantly increased NK cell activity (from 22.41 ±9.06% to 41.32± 14.21 %), concanavalin A-stimulated lymphocyte blastoid transformation (from 31463.8±4146.3 cpm to47744.0±4790.9cpm; P<0.05). The level of salivary slgA, however, was not significantly changed in this study. Conclusions: The intake of lactic bacteria is suggested to enhance immune function in adult humans. Source


Yanagisawa Y.,Miyama Co. | Yamamoto T.,TTC Co. | Kondo S.,Medical Corporation Kenshokai
Japanese Pharmacology and Therapeutics | Year: 2014

Objective: The aim of this study was to evaluate the intake of lactic bacteria (Lactobacillus brevis Miyavis LB) on factors related to lifestyle disease in adult volunteers with mild symptoms of lifestyle disease. Methods: Sixteen subjects (average of 47.7 ±7.9 years old) who had mild symptoms of lifestyle disease received lactic bacteria (4 g; ∼4 X 1010 cells) daily for 8 weeks, and their levels of lifestyle disease-related factors were evaluated. Results: The intake of lactic bacteria for 8 weeks significantly reduced systolic and diastolic blood pressure (from 132± 14 to 122± 17 mmHg and 85 ± 10 to 78 ± 10 mmHg, respectively P <0.05). In addition, serum total and LDL-cholesteroI reduced after 4th weeks after the intake (from237±29to220±29mg/dLand 150±32to 137±29mg/dL, respectively; P<0.05). Conclusions The intake of lactic bacteria is suggested to improve lifestyle disease symptoms in adult humans. Source


Nishikiori H.,Shinshu University | Takei M.,Shinshu University | Oki K.,Miyama Co. | Takano S.,Shinshu University | And 2 more authors.
Applied Catalysis B: Environmental | Year: 2012

Anatase-type nanocrystalline titania layers were prepared by oxidizing the crystalline titanium nitride and carbon-doped titanium nitride phases prepared on a titanium plate surface. Identification of the crystalline phase was confirmed by the XRD patterns and Raman spectra of these plates. The photocatalytic activity of the plates was evaluated by observing the photocalytic degradation process of acetaldehyde gas during UV irradiation by gas chromatography. A relatively larger amount of the anatase phase was formed on the very thin surface layer by heating the carbon-doped titanium nitride phase at 500. °C, and it exhibited a higher photocatalytic activity for the acetaldehyde degradation. The activity was determined not only by the amount of the anatase phase, but also by the crystallite size depending on the surface area and charge transfer efficiency. The photocatalytic activity is suggested to be due to the anatase phase existing on the thin surface layer accessible to the reactants. © 2012 Elsevier B.V. Source

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